PIM1 is a serine threonine kinase with roles in cellular proliferation, survival and escape from apoptosis. Its expression is upregulated in a number of hematological cancers (reviewed in Arrouchi et al, 2019; Zhang et al, 2018). PIM1 expression is upregulated in BaF3 cells expressing constitutively activated STAT5, and STAT5-mediated upregulation of PIM1 has been shown downstream of FLT ITD and ETV6-FLT3 fusion mutants (Nosaka et al, 1999; Kim et al, 2005; Vu et al, 2009; Okada et al, 2018).
Zhang, X, Song, M, Kundu, JK, Lee, MH, Liu, ZZ
Kim, KT, Baird, K, Ahn, JY, Meltzer, P, Lilly, M, Levis, M, Small, D
Vu, HA, Xinh, PT, Kano, Y, Tokunaga, K, Sato, Y
Nosaka, T, Kawashima, T, Misawa, K, Ikuta, K, Mui, AL, Kitamura, T
Arrouchi, H, Lakhlili, W, Ibrahimi, A
Okada, K, Nogami, A, Ishida, S, Akiyama, H, Chen, C, Umezawa, Y, Miura, O
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