STAT5-dependent PIM1 gene expression downstream of FLT3 ITD and fusion mutants

Stable Identifier
R-HSA-9703436
Type
Reaction [omitted]
Species
Homo sapiens
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PIM1 is a serine threonine kinase with roles in cellular proliferation, survival and escape from apoptosis. Its expression is upregulated in a number of hematological cancers (reviewed in Arrouchi et al, 2019; Zhang et al, 2018). PIM1 expression is upregulated in BaF3 cells expressing constitutively activated STAT5, and STAT5-mediated upregulation of PIM1 has been shown downstream of FLT ITD and ETV6-FLT3 fusion mutants (Nosaka et al, 1999; Kim et al, 2005; Vu et al, 2009; Okada et al, 2018).

Literature References
PubMed ID Title Journal Year
30370255 PIM Kinase as an Executional Target in Cancer

Zhang, X, Song, M, Kundu, JK, Lee, MH, Liu, ZZ

2018
15498859 Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival

Kim, KT, Baird, K, Ahn, JY, Meltzer, P, Lilly, M, Levis, M, Small, D

Blood 2005
19345670 The juxtamembrane domain in ETV6/FLT3 is critical for PIM-1 up-regulation and cell proliferation

Vu, HA, Xinh, PT, Kano, Y, Tokunaga, K, Sato, Y

2009
10469654 STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells

Nosaka, T, Kawashima, T, Misawa, K, Ikuta, K, Mui, AL, Kitamura, T

1999
31359998 A review on PIM kinases in tumors

Arrouchi, H, Lakhlili, W, Ibrahimi, A

2019
29507660 FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway

Okada, K, Nogami, A, Ishida, S, Akiyama, H, Chen, C, Umezawa, Y, Miura, O

2018
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Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
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