PIM1 is a serine threonine kinase with roles in cellular proliferation, survival and escape from apoptosis. Its expression is upregulated in a number of hematological cancers (reviewed in Arrouchi et al, 2019; Zhang et al, 2018). PIM1 expression is upregulated in BaF3 cells expressing constitutively activated STAT5, and STAT5-mediated upregulation of PIM1 has been shown downstream of FLT ITD and ETV6-FLT3 fusion mutants (Nosaka et al, 1999; Kim et al, 2005; Vu et al, 2009; Okada et al, 2018).
Xinh, PT, Vu, HA, Kano, Y, Tokunaga, K, Sato, Y
Okada, K, Akiyama, H, Miura, O, Ishida, S, Umezawa, Y, Chen, C, Nogami, A
Levis, M, Ahn, JY, Small, D, Lilly, M, Kim, KT, Meltzer, P, Baird, K
Mui, AL, Kitamura, T, Ikuta, K, Misawa, K, Nosaka, T, Kawashima, T
Lakhlili, W, Ibrahimi, A, Arrouchi, H
Song, M, Lee, MH, Liu, ZZ, Kundu, JK, Zhang, X
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