Reactome | RYK [plasma membrane]

RYK [plasma membrane]

Stable Identifier

R-HSA-3006746

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Tyrosine-protein kinase RYK ecNumber2.7.10.1/ecNumber, RYK_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P34925 RYK

Gene Names

RYK, JTK5A

Chain

signal peptide:1-25, chain:26-607

Reference Genes

BioGPS Gene:6259 RYK

COSMIC (genes):RYK RYK

CTD Gene:6259 RYK

dbSNP Gene:6259 RYK

ENSEMBL:ENSG00000163785 RYK

HGNC:10481 RYK

KEGG:hsa:6259 RYK

Monarch:6259 RYK

NCBI Gene:6259 RYK

OMIM:600524 RYK

UCSC:P34925 RYK

Reference Transcript

Other Identifiers

11740589_s_at

16959412

202853_PM_s_at

202853_s_at

214172_PM_x_at

214172_x_at

216976_PM_s_at

216976_s_at

2696202

2696203

2696204

2696254

2696255

2696256

2696257

2696258

2696260

2696261

2696262

2696264

2696265

2696266

2696267

2696269

2696271

2696272

2696273

2696274

2696278

2696279

2696280

2696281

2696282

2696287

2696292

2696293

2696295

2696296

3706890

3706892

3706895

3706896

3706898

37756_at

539_at

6259

8090840

A_21_P0002880

A_24_P229377

A_33_P3379371

GE514515

GE58784

GO:0003824

GO:0004672

GO:0004713

GO:0004888

GO:0005109

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005886

GO:0006468

GO:0007165

GO:0007169

GO:0007409

GO:0007411

GO:0007416

GO:0010976

GO:0015026

GO:0016020

GO:0016055

GO:0016301

GO:0016740

GO:0017147

GO:0022008

GO:0022038

GO:0030154

GO:0030182

GO:0031175

GO:0034330

GO:0035567

GO:0036518

GO:0042813

GO:0043226

GO:0043235

GO:0043410

GO:0048705

GO:0048787

GO:0048843

GO:0048846

GO:0048856

GO:0050919

GO:0051897

GO:0060070

GO:0060071

GO:0060089

GO:0071679

GO:0098839

GO:0098978

GO:0140096

GO:1904935

GO:1904948

HMNXSV003003782

HMNXSV003009303

Hs.79350.2.S1_3p_a_at

ILMN_1658526

ILMN_1769671

ILMN_1855117

ILMN_2363439

PH_hs_0040130

S59184_at

TC03003100.hg

TC03003415.hg

TC03003416.hg

g11863158_3p_a_at

g11863158_3p_x_at

p11512

Participates

as a component of

as an input of

Inferred To

RYK [plasma membrane] (Bos taurus)

RYK [plasma membrane] (Canis familiaris)

RYK [plasma membrane] (Gallus gallus)

RYK [plasma membrane] (Sus scrofa)

Ryk [plasma membrane] (Mus musculus)

Ryk [plasma membrane] (Rattus norvegicus)

dnt [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_001005861.1, NP_002949.2

Guide to Pharmacology - Targets

1849

ENSEMBL

ENST00000623711, ENSP00000478721, ENSG00000163785, ENSP00000485095, ENST00000620660

OpenTargets

ENSG00000163785

GeneCards

RYK

HPA

ENSG00000163785-RYK

PRO

P34925

Pharos - Targets

P34925

GlyGen

P34925

HMDB Protein

HMDBP01453

PDB

6TUA

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04439 HLA-A	9	HLA class I histocompatibility antigen, A-3 alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-983100) HLA class I histocompatibility antigen, A-3 alpha chain precursor [early endosome membrane] (R-HSA-1236826) HLA class I histocompatibility antigen, A-3 alpha chain precursor [plasma membrane] (R-HSA-197642) HLA class I histocompatibility antigen, A-3 alpha chain precursor [phagocytic vesicle membrane] (R-HSA-1236740) HLA class I histocompatibility antigen, A-3 alpha chain precursor [recycling endosome membrane] (R-HSA-8863889) HLA class I histocompatibility antigen, A-3 alpha chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-983347) HLA class I histocompatibility antigen, A-3 alpha chain precursor [Golgi membrane] (R-HSA-983376) HLA-A A-3 [endoplasmic reticulum membrane] (R-HSA-8943090) K48polyUb-HLA-A A-2 [endoplasmic reticulum membrane] (R-HSA-8943073)	0.569	3
UniProt:Q8IWK6 AGRA3			0.569	5
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.569	3
UniProt:Q15375 EPHA7	2	p-Y608,Y614-EPHA7 [plasma membrane] (R-HSA-3928358) EPHA7 [plasma membrane] (R-HSA-2682337)	0.527	2
UniProt:O60245 PCDH7	2	PCDH7 [plasma membrane] (R-HSA-8848879) PCDH7 [platelet alpha granule membrane] (R-HSA-8848917)	0.527	3
UniProt:Q9Y5G0 PCDGH			0.527	2
UniProt:Q68D85 NCR3LG1	1	NCR3LG1 [plasma membrane] (R-HSA-5683240)	0.527	3
UniProt:Q86YT6 MIB1	1	MIB1 [cytosol] (R-HSA-1472877)	0.483	4
UniProt:Q9ULH0 KIDINS220	2	p-Y1095-KIDINS220 [cytosol] (R-HSA-169869) KIDINS220 [cytosol] (R-HSA-169880)	0.483	2
UniProt:P29317 EPHA2	2	p-Y588,Y594-EPHA2 [plasma membrane] (R-HSA-3928380) EPHA2 [plasma membrane] (R-HSA-211422)	0.483	2
UniProt:O75976 CPD	3	CPD [Golgi membrane] (R-HSA-432675) CPD [cytoplasmic vesicle membrane] (R-HSA-432671) CPD [plasma membrane] (R-HSA-9715182)	0.483	2
UniProt:Q9UBH6 S53A1			0.483	2

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