Wnt5a binds RYK and VANGL2

Stable Identifier
R-NUL-4551554
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
General
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PNG
Low
Medium
High
 | PPTX  | SBGN
Wnt5a binds RYK and VANGL2
Purified human RYK binds to mouse Wnt1, 3a and 5a expressed in HEK293 cells. Separate experiments show that human RYK also immunopreciptitates human VANGL2 when the proteins are co-expressed in HEK293 cells. The existence of a ternary Wnt5a:RYK:VANGL2 complex has not been explicitly demonstrated (Macheda et al, 2012).
Literature References
PubMed ID Title Journal Year
22773843 The Wnt receptor Ryk plays a role in mammalian planar cell polarity signaling

Lieschke, GJ, Kugathasan, K, Halford, MM, Sun, WW, Zhang, YF, Stacker, SA, Jacques, BE, Bower, NI, Hogan, BM, Dabdoub, A, Macheda, ML

J. Biol. Chem. 2012
Participants
Input
Output
Orthologous Events
RYK binds WNT5A and VANGL2 (Homo sapiens)
Authored
Rothfels, K  (2013-09-06)
Reviewed
Kikuchi, A  (2013-11-13)
Created
Rothfels, K  (2013-09-14)
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