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MIB1 [cytosol]
Stable Identifier
R-HSA-1472877
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase MIB1, Mind bomb homolog 1
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by NOTCH1 in Cancer (Homo sapiens)
Signaling by NOTCH1 HD Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD Domain Mutants (Homo sapiens)
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants (Homo sapiens)
MIB/NEURL [cytosol] (Homo sapiens)
MIB1 [cytosol] (Homo sapiens)
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (Homo sapiens)
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants (Homo sapiens)
MIB/NEURL [cytosol] (Homo sapiens)
MIB1 [cytosol] (Homo sapiens)
Signaling by NOTCH1 PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 PEST Domain Mutants (Homo sapiens)
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants (Homo sapiens)
MIB/NEURL [cytosol] (Homo sapiens)
MIB1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
Activated NOTCH1 Transmits Signal to the Nucleus (Homo sapiens)
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 (Homo sapiens)
MIB/NEURL [cytosol] (Homo sapiens)
MIB1 [cytosol] (Homo sapiens)
Signaling by NOTCH2 (Homo sapiens)
NOTCH2 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
Ubiquitination of DLL/JAG ligands upon binding to NOTCH2 (Homo sapiens)
MIB/NEURL [cytosol] (Homo sapiens)
MIB1 [cytosol] (Homo sapiens)
Signaling by NOTCH3 (Homo sapiens)
NOTCH3 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
Ubiquitination of DLL/JAG ligands upon binding to NOTCH3 (Homo sapiens)
MIB/NEURL [cytosol] (Homo sapiens)
MIB1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86YT6 MIB1
Gene Names
MIB1, DIP1, KIAA1323, ZZANK2
Chain
chain:1-1006
Reference Genes
BioGPS Gene:57534 MIB1
COSMIC (genes):MIB1 MIB1
CTD Gene:57534 MIB1
dbSNP Gene:57534 MIB1
ENSEMBL:ENSG00000101752 MIB1
HGNC:21086 MIB1
KEGG:hsa:57534 MIB1
Monarch:57534 MIB1
NCBI Gene:57534 MIB1
OMIM:608677 MIB1
UCSC:Q86YT6 MIB1
Reference Transcript
RefSeq:NM_020774.3 MIB1
Other Identifiers
11726637_at
11726638_at
11726639_at
11726640_x_at
11726641_at
16851353
224720_PM_at
224720_at
224722_PM_at
224722_at
224725_PM_at
224725_at
224726_PM_at
224726_at
3781125
3781132
3781133
3781134
3781135
3781136
3781137
3781138
3781141
3781142
3781145
3781148
3781149
3781152
3781156
3781157
3781158
3781164
3781167
3781168
3781171
3781172
3781174
3781175
3781176
3781177
3781178
3781179
3781183
3781185
3781187
3781188
3781189
3781190
3781191
3781192
3781193
3781194
45761_at
50934_at
55971_at
57534
60289_at
61693_at
8020423
A_14_P104151
A_14_P104917
A_14_P122575
A_23_P433838
A_24_P943156
A_32_P121651
A_33_P3347976
GE488246
GE85995
GO:0001568
GO:0001701
GO:0001756
GO:0001841
GO:0001947
GO:0003824
GO:0004842
GO:0005515
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0006511
GO:0006897
GO:0007219
GO:0007507
GO:0008270
GO:0014069
GO:0016192
GO:0016567
GO:0016740
GO:0030154
GO:0030182
GO:0031410
GO:0034451
GO:0043226
GO:0045665
GO:0045807
GO:0046872
GO:0048856
GO:0061630
GO:0098978
GO:0140096
HMNXSV003016880
Hs.34892.0.S1_3p_at
Hs.34892.0.S2_3p_at
Hs.34892.0.S3_3p_at
Hs.34892.0.S4_3p_at
ILMN_1788832
PH_hs_0002851
TC18000090.hg
Participates
as a member of
MIB/NEURL [cytosol] (Homo sapiens)
Cross References
RefSeq
NP_065825.1
ENSEMBL
ENSP00000261537
,
ENST00000261537
OpenTargets
ENSG00000101752
IntEnz
2.3.2.27
HPA
ENSG00000101752-MIB1
PRO
Q86YT6
Pharos - Targets
Q86YT6
Orphanet
MIB1
HMDB Protein
HMDBP11557
PDB
4XI6
,
4TSE
,
4XI7
,
4XIB
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UHD2 TBK1
5
p-S172-TBK1 [cytosol]
(R-HSA-168379)
TBK1 [cytosol]
(R-HSA-166267)
K63polyUb-K30,K401-TBK1 [cytosol]
(R-HSA-9730430)
p-TBK1 [cytosol]
(R-HSA-9008705)
pS-172,K48polyUb-TBK1 [cytosol]
(R-HSA-3249397)
0.499
2
UniProt:P34925 RYK
1
RYK [plasma membrane]
(R-HSA-3006746)
0.483
4
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