Reactome | LEPR-1 [plasma membrane]

LEPR-1 [plasma membrane]

Stable Identifier

R-HSA-2586526

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

LEPR (long isoform), Leptin receptor, LEPR_HUMAN, LEPRb, OBRl, LEPR isoform 1, OBRb

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Literature References

PubMed ID	Title	Journal	Year
9405487	Divergent signaling capacities of the long and short isoforms of the leptin receptor da Silva, B, Uotani, S, Flier, JS, Bjørbaek, C	J. Biol. Chem.	1997

External Reference Information

External Reference

UniProt:P48357-1 LEPR

Gene Names

LEPR, DB, OBR

Participates

as a component of

LEPR dimer [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-Y986,Y1079,Y1141-LEPR-1 [plasma membrane]

Cross References

Guide to Pharmacology - Targets

1712

OpenTargets

ENSG00000116678

ENSEMBL

ENST00000371060, ENSP00000483390, ENSG00000116678, ENSP00000330393, ENST00000349533, ENST00000344610, ENSP00000360097, ENST00000616738, ENSP00000360098, ENSP00000360099, ENST00000371059, ENSP00000340884, ENST00000371058

HPA

ENSG00000116678-LEPR

GeneCards

LEPR

PRO

P48357

Pharos - Targets

P48357

Orphanet

LEPR

PDB

3V6O, 6E2P, 8X85, 8X81, 7Z3Q, 8AVO, 8X80, 8AVE, 8AVF

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P41159 LEP	1	LEP [extracellular region] (R-HSA-400490)	0.59	3
UniProt:O43613 HCRTR1	1	HCRTR1 [plasma membrane] (R-HSA-389490)	0.581	4
UniProt:Q06124 PTPN11	4	p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573) PTPN11 [cytosol] (R-HSA-162563) PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y542-PTPN11 [cytosol] (R-HSA-1369081)	0.527	2

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