Reactome | LEPR dimer [plasma membrane]

LEPR dimer [plasma membrane]

Stable Identifier

R-HSA-2586530

Type

Complex

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
9218470	Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding Plaetinck, G, Kalai, M, White, DW, Fountoulakis, M, Devos, R, Van der Heyden, J, Guisez, Y	J. Biol. Chem.	1997
15051545	BiaCore analysis of leptin-leptin receptor interaction: evidence for 1:1 stoichiometry Moreau, F, Mistrík, P, Allen, JM	Anal. Biochem.	2004
10227390	Evidence for ligand-independent homo-oligomerization of leptin receptor (OB-R) isoforms: a proposed mechanism permitting productive long-form signaling in the presence of excess short-form expression White, DW, Tartaglia, LA	J. Cell. Biochem.	1999
12734179	Activation of the leptin receptor by a ligand-induced conformational change of constitutive receptor dimers Jockers, R, Couturier, C	J. Biol. Chem.	2003

Participants

components

x 2 LEPR-1 [plasma membrane] (Homo sapiens)

Participates

as a component of

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