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HCRTR1 [plasma membrane]
Stable Identifier
R-HSA-389490
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Orexin receptor 1, RecName: Full=Orexin receptor type 1; AltName: Full=Ox1r; AltName: Full=Hypocretin receptor type 1;
GN Name=HCRTR1;
OS Homo sapiens, OX1R_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HCRTR1:HCRT(34-66) [plasma membrane] (Homo sapiens)
HCRTR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HCRTR1:HCRT(34-66) [plasma membrane] (Homo sapiens)
HCRTR1 [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HCRTR1:HCRT(34-66) [plasma membrane] (Homo sapiens)
HCRTR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HCRTR1:HCRT(34-66) [plasma membrane] (Homo sapiens)
HCRTR1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
HCRTR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HCRTR1:HCRT(34-66) [plasma membrane] (Homo sapiens)
HCRTR1 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Orexin and neuropeptides FF and QRFP bind to their respective receptors (Homo sapiens)
Orexin 1 receptor can bind orexin-A neuropeptide (Homo sapiens)
HCRTR1 [plasma membrane] (Homo sapiens)
HCRTR1:HCRT(34-66) [plasma membrane] (Homo sapiens)
HCRTR1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43613 HCRTR1
Gene Names
HCRTR1
Chain
chain:1-425
Reference Genes
BioGPS Gene:3061 HCRTR1
COSMIC (genes):HCRTR1 HCRTR1
CTD Gene:3061 HCRTR1
dbSNP Gene:3061 HCRTR1
ENSEMBL:ENSG00000121764 HCRTR1
HGNC:4848 HCRTR1
KEGG:hsa:3061 HCRTR1
Monarch:3061 HCRTR1
NCBI Gene:3061 HCRTR1
OMIM:602392 HCRTR1
UCSC:O43613 HCRTR1
Reference Transcript
RefSeq:NM_001525.2 HCRTR1
RefSeq:XM_017001106.1 HCRTR1
RefSeq:XM_017001105.1 HCRTR1
Other Identifiers
11740653_a_at
16661890
207619_PM_at
207619_at
2328388
2328389
2328390
2328391
2328392
2328393
2328394
2328395
2328397
2328398
2328399
2328400
2328402
2328403
2328404
3061
33070_at
7899643
A_23_P74178
A_33_P3360249
GE54357
GO:0004930
GO:0005515
GO:0005886
GO:0007186
GO:0007218
GO:0007268
GO:0007631
GO:0016020
GO:0016499
GO:0017046
GO:0023052
GO:0032870
GO:0042277
GO:0045202
GO:0051480
GO:0060089
GO:0070374
HMNXSV003037949
HMNXSV003047921
ILMN_1660217
PH_hs_0024457
TC01000412.hg
g4557636_3p_at
Participates
as an input of
Orexin 1 receptor can bind orexin-A neuropeptide (Homo sapiens)
as a member of
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
as a component of
HCRTR1:HCRT(34-66) [plasma membrane] (Homo sapiens)
Inferred To
Hcrtr1 [plasma membrane]
(Mus musculus)
Hcrtr1 [plasma membrane]
(Rattus norvegicus)
HCRTR1 [plasma membrane]
(Bos taurus)
HCRTR1 [plasma membrane]
(Canis familiaris)
HCRTR1 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
XP_016856595.1
,
XP_016856594.1
,
NP_001516.2
ZINC - World Drugs
OX1R_HUMAN
Guide to Pharmacology - Targets
321
OpenTargets
ENSG00000121764
ENSEMBL
ENSP00000384387
,
ENST00000403528
,
ENSP00000362810
,
ENST00000373706
ZINC - FDA approved
OX1R_HUMAN
ZINC - Substances
OX1R_HUMAN
ZINC target
O43613
PRO
O43613
GlyGen
O43613
PDB
4ZJC
,
6TP3
,
6TQ4
,
6TOT
,
6TP4
,
6TQ6
,
6TOS
,
6TQ7
,
6TP6
,
6TQ9
,
6TO7
,
6TOD
,
4ZJ8
,
6V9S
ZINC - Investigational
OX1R_HUMAN
HPA
ENSG00000121764-HCRTR1
Pharos - Targets
O43613
ZINC - Predictions - Purchasable
OX1R_HUMAN
HMDB Protein
HMDBP14442
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P48357 LEPR
0.581
4
UniProt:P35414 APLNR
1
APLNR [plasma membrane]
(R-HSA-374259)
0.556
6
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