Reactome | 3x4Hyp-COL6A1(?-1028) [extracellular region]

3x4Hyp-COL6A1(?-1028) [extracellular region]

Stable Identifier

R-HSA-2470138

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

4-hydroxyprolyl collagen alpha-1(VI) chain C-term fragment

Locations in the PathwayBrowser

Expand all

Extracellular matrix organization (Homo sapiens)

- Degradation of the extracellular matrix (Homo sapiens)
  - Collagen degradation (Homo sapiens)
    - Collagen type VI degradation by MMP2,9,11 (Homo sapiens)
      - Cleaved collagen type VI fibril [extracellular region] (Homo sapiens)
        
        Cleaved tropocollagen type VI tetramer [extracellular region] (Homo sapiens)
        
        Cleaved tropocollagen type VI dimer [extracellular region] (Homo sapiens)
        
        Cleaved tropocollagen type VI [extracellular region] (Homo sapiens)
        
        Cleaved collagen alpha-1(VI) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-COL6A1(?-1028) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P12109 COL6A1

Gene Names

COL6A1

Chain

signal peptide:1-19, chain:20-1028

Reference Genes

BioGPS Gene:1291 COL6A1

COSMIC (genes):COL6A1 COL6A1

CTD Gene:1291 COL6A1

dbSNP Gene:1291 COL6A1

ENSEMBL:ENSG00000142156 COL6A1

ENSEMBL_homo_sapiens_GENE:ENSG00000142156.16 COL6A1

HGNC:2211 COL6A1

KEGG Gene (Homo sapiens):1291 COL6A1

Monarch:1291 COL6A1

NCBI Gene:1291 COL6A1

OMIM:120220 COL6A1

UCSC:P12109 COL6A1

Reference Transcript

RefSeq:NM_001848.2 COL6A1

Other Identifiers

11715403_a_at

11715404_a_at

11715405_x_at

11715406_a_at

11752383_a_at

11752384_s_at

1291

16923842

212091_PM_s_at

212091_s_at

212937_3p_s_at

212937_PM_s_at

212937_s_at

212938_PM_at

212938_at

212940_PM_at

212940_at

213428_PM_s_at

213428_s_at

38722_at

3924373

3924374

3924375

3924376

3924377

3924379

3924382

3924383

3924384

3924385

3924386

3924387

3924388

3924389

3924391

3924392

3924393

3924395

3924396

3924397

3924398

3924399

3924400

3924401

3924402

3924406

3924407

3924408

3924409

3924410

3924411

3924413

3924414

3924415

3924416

41350_at

57615_at

80349_s_at

8069269

A_14_P101156

A_14_P136963

A_24_P331918

A_32_P32254

GE61971

GO:0000302

GO:0000902

GO:0001503

GO:0001649

GO:0001942

GO:0002023

GO:0003012

GO:0003016

GO:0005198

GO:0005518

GO:0005576

GO:0005581

GO:0005589

GO:0005604

GO:0005615

GO:0005739

GO:0005764

GO:0005765

GO:0005773

GO:0005783

GO:0005788

GO:0005886

GO:0005975

GO:0006091

GO:0006096

GO:0006099

GO:0006103

GO:0006112

GO:0006914

GO:0006915

GO:0006954

GO:0006996

GO:0007005

GO:0007155

GO:0007338

GO:0007422

GO:0007507

GO:0007517

GO:0007519

GO:0007623

GO:0008286

GO:0008361

GO:0009410

GO:0009411

GO:0009611

GO:0009612

GO:0009636

GO:0010467

GO:0010657

GO:0012501

GO:0014823

GO:0014850

GO:0016020

GO:0016529

GO:0019226

GO:0022011

GO:0022414

GO:0023052

GO:0030016

GO:0030020

GO:0030154

GO:0030198

GO:0030199

GO:0030262

GO:0030282

GO:0030312

GO:0030324

GO:0031012

GO:0032496

GO:0032963

GO:0032991

GO:0033993

GO:0035987

GO:0036022

GO:0036293

GO:0042383

GO:0043226

GO:0043403

GO:0043491

GO:0043588

GO:0048009

GO:0048265

GO:0048286

GO:0048407

GO:0048630

GO:0048741

GO:0048771

GO:0048856

GO:0048872

GO:0050877

GO:0050954

GO:0051216

GO:0051262

GO:0051402

GO:0051882

GO:0055001

GO:0055085

GO:0055086

GO:0060065

GO:0060070

GO:0060348

GO:0060425

GO:0060487

GO:0060538

GO:0060612

GO:0061024

GO:0061061

GO:0062023

GO:0065003

GO:0070062

GO:0070341

GO:0070836

GO:0071230

GO:0071711

GO:0071965

GO:0072593

GO:0085029

GO:0097009

GO:0097708

GO:0098528

GO:1901135

GO:1901652

GO:1904026

GO:1904583

GO:1904975

GO:1990542

HMNXSV003034787

Hs.108885.0.A1_3p_a_at

Hs.108885.1.S1_3p_a_at

Hs.25459.0.S1_3p_at

Hs.25459.0.S2_3p_at

Hs.25459.0.S2_3p_s_at

ILMN_1732151

PH_hs_0025035

TC21000249.hg

X15880_at

Participates

as a member of

Cleaved collagen alpha-1(VI) chains [extracellular region] (Homo sapiens)

Other forms of this molecule

GalHyl-COL6A1 [endoplasmic reticulum lumen]

3x4Hyp-GlcGalHyl-COL6A1 [endoplasmic reticulum lumen]

GlcGalHyl-COL6A1 [endoplasmic reticulum lumen]

3x4Hyp-GalHyl-COL6A1 [endoplasmic reticulum lumen]

3x4Hyp-3Hyp-GalHyl-COL6A1 [endoplasmic reticulum lumen]

3x4Hyp-3Hyp-GlcGalHyl-COL6A1 [endoplasmic reticulum lumen]

COL6A1 [endoplasmic reticulum lumen]

3x4Hyp-COL6A1 [endoplasmic reticulum lumen]

3x4Hyp-3Hyp-COL6A1 [endoplasmic reticulum lumen]

3x4Hyp-5Hyl-COL6A1 [endoplasmic reticulum lumen]

3x4Hyp-3Hyp-5Hyl-COL6A1 [endoplasmic reticulum lumen]

5Hyl-COL6A1 [endoplasmic reticulum lumen]

COL6A1(?-1028) [extracellular region]

3x4Hyp-COL6A1(20-?) [extracellular region]

GalHyl-COL6A1(20-?) [extracellular region]

3x4Hyp-5Hyl-COL6A1(?-1028) [extracellular region]

3x4Hyp-3Hyp-5Hyl-COL6A1(20-?) [extracellular region]

GlcGalHyl-COL6A1(20-?) [extracellular region]

3x4Hyp-3Hyp-GalHyl-COL6A1(?-1028) [extracellular region]

COL6A1(20-?) [extracellular region]

3x4Hyp-3Hyp-GalHyl-COL6A1(20-?) [extracellular region]

GlcGalHyl-COL6A1(?-1028) [extracellular region]

3x4Hyp-GlcGalHyl-COL6A1(20-?) [extracellular region]

5Hyl-COL6A1(?-1028) [extracellular region]

GalHyl-COL6A1(?-1028) [extracellular region]

3x4Hyp-3Hyp-5Hyl-COL6A1(?-1028) [extracellular region]

3x4Hyp-GalHyl-COL6A1(20-?) [extracellular region]

3x4Hyp-3Hyp-GlcGalHyl-COL6A1(20-?) [extracellular region]

3x4Hyp-3Hyp-GalHyl-COL6A1 [extracellular region]

3x4Hyp-3Hyp-GlcGalHyl-COL6A1 [extracellular region]

3x4Hyp-5Hyl-COL6A1 [extracellular region]

GalHyl-COL6A1 [extracellular region]

3x4Hyp-GlcGalHyl-COL6A1 [extracellular region]

3x4Hyp-3Hyp-5Hyl-COL6A1 [extracellular region]

3x4Hyp-COL6A1 [extracellular region]

COL6A1 [extracellular region]

3x4Hyp-3Hyp-COL6A1 [extracellular region]

3x4Hyp-GalHyl-COL6A1 [extracellular region]

GlcGalHyl-COL6A1 [extracellular region]

5Hyl-COL6A1 [extracellular region]

3x4Hyp-GlcGalHyl-COL6A1(?-1028) [extracellular region]

3x4Hyp-3Hyp-GlcGalHyl-COL6A1(?-1028) [extracellular region]

3x4Hyp-3Hyp-COL6A1(?-1028) [extracellular region]

3x4Hyp-5Hyl-COL6A1(20-?) [extracellular region]

5Hyl-COL6A1(20-?) [extracellular region]

3x4Hyp-3Hyp-COL6A1(20-?) [extracellular region]

3x4Hyp-GalHyl-COL6A1(?-1028) [extracellular region]

Inferred To

Col6a1 [extracellular region] (Mus musculus)

3x4Hyp-COL6A1(?-1028) [extracellular region] (Caenorhabditis elegans)

3x4Hyp-COL6A1(?-1028) [extracellular region] (Dictyostelium discoideum)

COL6A1 [extracellular region] (Bos taurus)

COL6A1 [extracellular region] (Sus scrofa)

Modified Residues

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Cross References

RefSeq

NP_001839.2

OpenTargets

ENSG00000142156

GeneCards

P12109

HPA

ENSG00000142156-COL6A1

Ensembl

ENST00000361866, ENSG00000142156, ENSP00000355180

PRO

P12109

Pharos - Targets

P12109

Orphanet

15778

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P14780 MMP9	8	MMP9 [ficolin-1-rich granule lumen] (R-HSA-6800973) MMP9 [tertiary granule lumen] (R-HSA-6800181) MMP9(60-106) [extracellular region] (R-HSA-1604699) MMP9(60-707) [extracellular region] (R-HSA-1604726) MMP9(20-59) [extracellular region] (R-HSA-1604685) MMP9(20-106) [extracellular region] (R-HSA-1604713) MMP9(20-707) [extracellular region] (R-HSA-1604376) MMP9(107-707) [extracellular region] (R-HSA-668812)	0.527	2
UniProt:P08253 MMP2	5	MMP2(67-109) [extracellular region] (R-HSA-1604371) MMP2(67-660) [extracellular region] (R-HSA-1604345) MMP2(30-66) [extracellular region] (R-HSA-1604347) MMP2(30-660) [extracellular region] (R-HSA-1604364) MMP2(110-660) [extracellular region] (R-HSA-381456)	0.527	2
UniProt:P59665 DEFA1	9	DEFA1(65-94) [azurophil granule lumen] (R-HSA-1470053) omega-N-(ADP-ribosyl)-L-arginine-DEFA1(65-94) [extracellular region] (R-HSA-1972397) DEFA1(65-94) [extracellular region] (R-HSA-1462022) DEFA1(66-94) [azurophil granule lumen] (R-HSA-1470038) DEFA1(66-94) [extracellular region] (R-HSA-1461998) DEFA1(20-65) [Golgi lumen] (R-HSA-8864970) DEFA1(66-94) [Golgi lumen] (R-HSA-975663) DEFA1(20-94) [Golgi lumen] (R-HSA-1467282) DEFA1(1-94) [Golgi lumen] (R-HSA-1467215)	0.527	2
UniProt:P0DTC8 8	2	8 [extracellular region] (R-COV-9755410) 8 [endoplasmic reticulum lumen] (R-COV-9727283)	0.527	2

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