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Fibronectin matrix [extracellular region]
Stable Identifier
R-HSA-2327729
Type
Polymer
Species
Homo sapiens
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Homo sapiens)
PDE4D5 in p-S26-ANXA2:PP2A:PDE4D5:ITGA5:ITGB1:fibronectin hydrolyzes cAMP to yield AMP (Homo sapiens)
p-S26-ANXA2:PP2A:PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
PP2A dephosphorylates serine-127 of YAP1 (Homo sapiens)
p-S26-ANXA2:PP2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
PP2A dephosphorylates serine-715 of PDE4D5 in p-S715-PDE4D5:integrin alpha5:integrin beta1:fibronectin (Homo sapiens)
p-S26-ANXA2:PP2A:PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
p-S26-ANXA2:PP2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
PPP2CA and PPP2R1A,B bind PPP2R2A in p-S26-ANXA2:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin (Homo sapiens)
p-S26-ANXA2:PP2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
p-S26-ANXA2:PPP2R2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
PPP2R2A binds p-S715-PDE4D5 in p-S26-ANXA2:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin (Homo sapiens)
p-S26-ANXA2:PPP2R2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
p-S26-ANXA2:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress (Homo sapiens)
p-S26-ANXA2:ITGA5:ITGB1:Ca2+:fibronectin [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
Phosphorylation of PTK2 (FAK) on tyrosine-397 in response to turbulent blood flow (Homo sapiens)
p-S26-ANXA2:ITGA5:ITGB1:Ca2+:fibronectin [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
p-S26-ANXA2:integrin alpha5:integrin beta1 (p-S26-ANXA2:ITGA5:ITGB1) binds fibronectin (FN1) matrix (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
p-S26-ANXA2:ITGA5:ITGB1:Ca2+:fibronectin [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
p-S715-PDE4D5 binds p-S26-ANXA2:integrin alpha5:integrin beta1:fibronectin (p-S26-ANXA2:ITGA5:ITGB1:fibronectin) (Homo sapiens)
p-S26-ANXA2:ITGA5:ITGB1:Ca2+:fibronectin [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
p-S26-ANXA2:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Fibronectin degradation by ADAM8 (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
Fibronectin degradation by CTSG (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
Fibronectin degradation by MMP10 (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
Fibronectin degradation by MMP14 (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
ECM proteoglycans (Homo sapiens)
Tenascins C, R, (X, N) bind fibronectin matrix (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
Tenascins C, R, (X, N):Fibronectin matrix [extracellular region] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
Elastic fibre formation (Homo sapiens)
Molecules associated with elastic fibres (Homo sapiens)
Fibulin-1 and -2 bind fibronectin (Homo sapiens)
FBLN1, FBLN2:Fibronectin matrix [extracellular region] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
Fibronectin matrix formation (Homo sapiens)
FN1 aggregation (Homo sapiens)
Integrin alpha5beta1:Fibronectin matrix [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
Integrin alpha4beta1, alpha8beta1, alphaVbeta6:Fibronectin matrix [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
Non-integrin membrane-ECM interactions (Homo sapiens)
HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Homo sapiens)
FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
HSPG2:FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Homo sapiens)
FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
Syndecan interactions (Homo sapiens)
Syndecan-1 binds fibronectin (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
Syndecan-1:Fibronectin matrix [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
GPER1 signaling (Homo sapiens)
p-SHC1 binds integrin alpha5beta1:fibronectin (Homo sapiens)
Integrin alpha5beta1:Fibronectin matrix [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
integrin alpha5beta1:Fibronectin matrix:pY-SHC1 [plasma membrane] (Homo sapiens)
Integrin alpha5beta1:Fibronectin matrix [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by MET (Homo sapiens)
MET promotes cell motility (Homo sapiens)
MET activates PTK2 signaling (Homo sapiens)
PTK2 binds activated MET (Homo sapiens)
Integrin alpha2beta1,alpha3:beta1:(collagen,laminin,fibronectin) [plasma membrane] (Homo sapiens)
Collagen, laminin, fibronectin [extracellular region] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
Participants
repeated unit
FN1 dimer [extracellular region]
(Homo sapiens)
Participates
as a component of
Tenascins C, R, (X, N):Fibronectin matrix [extracellular region] (Homo sapiens)
Syndecan-1:Fibronectin matrix [plasma membrane] (Homo sapiens)
FBLN1, FBLN2:Fibronectin matrix [extracellular region] (Homo sapiens)
p-S26-ANXA2:ITGA5:ITGB1:Ca2+:fibronectin [plasma membrane] (Homo sapiens)
p-S26-ANXA2:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
p-S26-ANXA2:PPP2R2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
p-S26-ANXA2:PP2A:PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
p-S26-ANXA2:PP2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
Integrin alpha5beta1:Fibronectin matrix [plasma membrane] (Homo sapiens)
Integrin alpha4beta1, alpha8beta1, alphaVbeta6:Fibronectin matrix [plasma membrane] (Homo sapiens)
as an input of
Tenascins C, R, (X, N) bind fibronectin matrix (Homo sapiens)
Syndecan-1 binds fibronectin (Homo sapiens)
Fibulin-1 and -2 bind fibronectin (Homo sapiens)
Fibronectin degradation by CTSG (Homo sapiens)
Fibronectin degradation by ADAM8 (Homo sapiens)
Fibronectin degradation by MMP10 (Homo sapiens)
Fibronectin degradation by MMP14 (Homo sapiens)
Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Homo sapiens)
p-S26-ANXA2:integrin alpha5:integrin beta1 (p-S26-ANXA2:ITGA5:ITGB1) binds fibronectin (FN1) matrix (Homo sapiens)
Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Homo sapiens)
as a member of
FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Homo sapiens)
as a candidate of
Collagen, laminin, fibronectin [extracellular region] (Homo sapiens)
Inferred To
Fibronectin matrix [extracellular region]
(Bos taurus)
Fibronectin matrix [extracellular region]
(Caenorhabditis elegans)
Fibronectin matrix [extracellular region]
(Canis familiaris)
Fibronectin matrix [extracellular region]
(Danio rerio)
Fibronectin matrix [extracellular region]
(Dictyostelium discoideum)
Fibronectin matrix [extracellular region]
(Drosophila melanogaster)
Fibronectin matrix [extracellular region]
(Gallus gallus)
Fibronectin matrix [extracellular region]
(Mus musculus)
Fibronectin matrix [extracellular region]
(Rattus norvegicus)
Fibronectin matrix [extracellular region]
(Sus scrofa)
Fibronectin matrix [extracellular region]
(Xenopus tropicalis)
Cross References
ChEBI
36080
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