Fibronectin degradation by MMP14

Stable Identifier
R-HSA-2533950
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
4/5
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Fibronectin degradation by MMP14
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MMP14 (MT1-MMP) can degrade fibronectin (Shi & Sottile 2011; Takino et al. 2011). Studies have shown that fibronectin turnover is not prevented by protease inhibitors (Sottile & Hocking 2002) and suggest that caveolin-1-mediated endocytosis and intracellular degradation are involved (Salicioni et al. 2002, Sottile & Chandler 2004).
Literature References
PubMed ID Title Journal Year
21985969 Membrane-type 1 matrix metalloproteinase regulates fibronectin assembly to promote cell motility

Sekiguchi, K, Manabe, R, Takino, T, Sato, H, Domoto, T, Nagao, R

FEBS Lett 2011
22159414 MT1-MMP regulates the turnover and endocytosis of extracellular matrix fibronectin

Sottile, J, Shi, F

J. Cell. Sci. 2011
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Output
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as an event of
Catalyst Activity

metalloendopeptidase activity of MMP14 [plasma membrane]

Physical Entity
MMP14 [plasma membrane] (Homo sapiens)
Activity
metalloendopeptidase activity (GO:0004222)
Orthologous Events
Fibronectin degradation by MMP14 (Bos taurus)
Fibronectin degradation by MMP14 (Caenorhabditis elegans)
Fibronectin degradation by MMP14 (Canis familiaris)
Fibronectin degradation by MMP14 (Mus musculus)
Fibronectin degradation by MMP14 (Rattus norvegicus)
Fibronectin degradation by MMP14 (Sus scrofa)
Fibronectin degradation by MMP14 (Xenopus tropicalis)
Authored
Jupe, S  (2012-08-08)
Reviewed
Ricard-Blum, S  (2013-08-13)
Created
Jupe, S  (2012-10-22)
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