MMP14 (MT1-MMP) can degrade fibronectin (Shi & Sottile 2011). Studies have shown that fibronectin turnover is not prevented by protease inhibitors (Sottile & Hocking 2002) and suggest that caveolin-1-mediated endocytosis and intracellular degradation are involved (Salicioni et al. 2002, Sottile & Chandler 2004).
Transmembrane protease serine 6 (Matriptase-2, TMPRSS6) is a transmembrane serine proteinase able to hydrolyze endogenous proteins such as type I collagen, fibronectin, and fibrinogen (Velasco et al. 2002).