MMP14 (MT1-MMP) can degrade fibronectin (Shi & Sottile 2011). Studies have shown that fibronectin turnover is not prevented by protease inhibitors (Sottile & Hocking 2002) and suggest that caveolin-1-mediated endocytosis and intracellular degradation are involved (Salicioni et al. 2002, Sottile & Chandler 2004). Transmembrane protease serine 6 (Matriptase-2, TMPRSS6) is a transmembrane serine proteinase able to hydrolyze endogenous proteins such as type I collagen, fibronectin, and fibrinogen (Velasco et al. 2002).
Velasco, G, Cal, S, Quesada, V, Sánchez, LM, López-Otín, C
Shi, F, Sottile, J
metalloendopeptidase activity of MMP14,TMPRSS6 [plasma membrane]
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