Fibulin-1 and -2 bind fibronectin

Stable Identifier
R-HSA-2537665
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
FBLN1, FBLN2 bind fibronectin
ReviewStatus
5/5
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Fibulin-1 and -2 bind fibronectin
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Fibulins are a family of 7 extracellular calcium binding proteins that have developmental roles (Twal et al. 2001). Fibulins 1-5 are found in association with elastic fibers. Fibulin-1 binds fibronectin (Balbona et al. 1992, Tran et al. 1997) suppressing fibronectin-mediated inhibitory effects on cell attachment and spreading (Twal et al. 2001). Fibulin-2 also binds fibronectin (Sasaki et al. 1995).
Literature References
PubMed ID Title Journal Year
7500359 Binding of mouse and human fibulin-2 to extracellular matrix ligands

Timpl, R, Sasaki, T, Pan, TC, Chu, ML, Göhring, W

J. Mol. Biol. 1995
1400330 Fibulin binds to itself and to the carboxyl-terminal heparin-binding region of fibronectin

Argraves, WS, Strickland, DK, Godyna, S, Ingham, KC, Balbona, K, Tran, H

J. Biol. Chem. 1992
Participants
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Output
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as an event of
Orthologous Events
Fibulin-1 and -2 bind fibronectin (Caenorhabditis elegans)
Fibulin-1 and -2 bind fibronectin (Canis familiaris)
Fibulin-1 and -2 bind fibronectin (Dictyostelium discoideum)
Fibulin-1 and -2 bind fibronectin (Gallus gallus)
Fibulin-1 and -2 bind fibronectin (Mus musculus)
Fibulin-1 and -2 bind fibronectin (Rattus norvegicus)
Authored
Jupe, S  (2012-04-30)
Reviewed
Muiznieks, LD  (2012-11-02)
Created
Jupe, S  (2012-10-31)
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