Fibronectin degradation by ADAM8

Stable Identifier
R-HSA-3788061
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Fibronectin degradation by ADAM8
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ADAM8 can cleave fibronectin in human cartilage extracts at Ala271/Val272, within a linker region between the fifth and sixth type I domains, producing ?30-kd and ?50–85-kd fragments with distinctive neoepitopes VRAA271 and 272VYQP that are associated with osteoarthritis (Zack et al. 2006, 2009).
Literature References
PubMed ID Title Journal Year
19714641 ADAM-8 isolated from human osteoarthritic chondrocytes cleaves fibronectin at Ala(271)

Griggs, DW, Arner, EC, Leone, JW, Radabaugh, MR, Skepner, AP, Nemirovskiy, OV, Yates, MP, Tortorella, MD, Alston, JT, Hall, T, Hills, RL, Malfait, AM, Zack, MD

Arthritis Rheum. 2009
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Output
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Catalyst Activity

serine-type endopeptidase activity of ADAM8 [plasma membrane]

Physical Entity
ADAM8 [plasma membrane] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
Fibronectin degradation by ADAM8 (Bos taurus)
Fibronectin degradation by ADAM8 (Caenorhabditis elegans)
Fibronectin degradation by ADAM8 (Canis familiaris)
Fibronectin degradation by ADAM8 (Gallus gallus)
Fibronectin degradation by ADAM8 (Mus musculus)
Fibronectin degradation by ADAM8 (Rattus norvegicus)
Fibronectin degradation by ADAM8 (Sus scrofa)
Authored
Jupe, S  (2012-08-08)
Reviewed
Ricard-Blum, S  (2013-08-13)
Created
Jupe, S  (2013-07-04)
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