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p-S26-ANXA2:PP2A:PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane]
Stable Identifier
R-HSA-9865195
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Homo sapiens)
PDE4D5 in p-S26-ANXA2:PP2A:PDE4D5:ITGA5:ITGB1:fibronectin hydrolyzes cAMP to yield AMP (Homo sapiens)
p-S26-ANXA2:PP2A:PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
PP2A dephosphorylates serine-715 of PDE4D5 in p-S715-PDE4D5:integrin alpha5:integrin beta1:fibronectin (Homo sapiens)
p-S26-ANXA2:PP2A:PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
Participants
components
Fibronectin matrix [extracellular region]
(Homo sapiens)
ITGA5:ITGB1 [plasma membrane]
(Homo sapiens)
p-S26-ANXA2 [cytosol]
(Homo sapiens)
PDE4D5:Zn2+:Mg2+ [cytosol]
(Homo sapiens)
PP2A (PPP2CA:PPP2R2A:PPP2R1A,B) [cytosol]
(Homo sapiens)
Participates
as an output of
PP2A dephosphorylates serine-715 of PDE4D5 in p-S715-PDE4D5:integrin alpha5:integrin beta1:fibronectin (Homo sapiens)
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