Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
FN1 dimer [extracellular region]
Stable Identifier
R-HSA-266103
Type
Complex
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Fibronectin dimer
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Homo sapiens)
PDE4D5 in p-S26-ANXA2:PP2A:PDE4D5:ITGA5:ITGB1:fibronectin hydrolyzes cAMP to yield AMP (Homo sapiens)
p-S26-ANXA2:PP2A:PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
PP2A dephosphorylates serine-127 of YAP1 (Homo sapiens)
p-S26-ANXA2:PP2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
PP2A dephosphorylates serine-715 of PDE4D5 in p-S715-PDE4D5:integrin alpha5:integrin beta1:fibronectin (Homo sapiens)
p-S26-ANXA2:PP2A:PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
p-S26-ANXA2:PP2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
PPP2CA and PPP2R1A,B bind PPP2R2A in p-S26-ANXA2:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin (Homo sapiens)
p-S26-ANXA2:PP2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
p-S26-ANXA2:PPP2R2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
PPP2R2A binds p-S715-PDE4D5 in p-S26-ANXA2:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin (Homo sapiens)
p-S26-ANXA2:PPP2R2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
p-S26-ANXA2:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress (Homo sapiens)
p-S26-ANXA2:ITGA5:ITGB1:Ca2+:fibronectin [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
Phosphorylation of PTK2 (FAK) on tyrosine-397 in response to turbulent blood flow (Homo sapiens)
p-S26-ANXA2:ITGA5:ITGB1:Ca2+:fibronectin [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
p-S26-ANXA2:integrin alpha5:integrin beta1 (p-S26-ANXA2:ITGA5:ITGB1) binds fibronectin (FN1) matrix (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
p-S26-ANXA2:ITGA5:ITGB1:Ca2+:fibronectin [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
p-S715-PDE4D5 binds p-S26-ANXA2:integrin alpha5:integrin beta1:fibronectin (p-S26-ANXA2:ITGA5:ITGB1:fibronectin) (Homo sapiens)
p-S26-ANXA2:ITGA5:ITGB1:Ca2+:fibronectin [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
p-S26-ANXA2:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
Developmental Biology (Homo sapiens)
Developmental Cell Lineages (Homo sapiens)
Developmental Cell Lineages of the Exocrine Pancreas (Homo sapiens)
Developmental Lineage of Pancreatic Ductal Cells (Homo sapiens)
Primary multipotent pancreatic progenitor cell produces trunk bipotent pancreatic progenitor cell (Homo sapiens)
(FN1 dimer, VTN) [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
Trunk bipotent pancreatic progenitor cell produces pancreatic ductal cell (Homo sapiens)
(FN1 dimer, VTN) [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Fibronectin degradation by ADAM8 (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
Fibronectin degradation by CTSG (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
Fibronectin degradation by MMP10 (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
Fibronectin degradation by MMP14 (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
ECM proteoglycans (Homo sapiens)
Tenascins C, R, (X, N) bind fibronectin matrix (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
Tenascins C, R, (X, N):Fibronectin matrix [extracellular region] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
Elastic fibre formation (Homo sapiens)
Molecules associated with elastic fibres (Homo sapiens)
Fibulin-1 and -2 bind fibronectin (Homo sapiens)
FBLN1, FBLN2:Fibronectin matrix [extracellular region] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
Fibronectin matrix formation (Homo sapiens)
FN1 aggregation (Homo sapiens)
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
Integrin alpha5beta1:Fibronectin matrix [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
FN1 dimerizes (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
Integrin alpha5beta1 binds FN1 dimer (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
Integrin alpha4beta1, alpha8beta1, alphaVbeta6:Fibronectin matrix [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
Non-integrin membrane-ECM interactions (Homo sapiens)
HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Homo sapiens)
FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
HSPG2:FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Homo sapiens)
FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
Syndecan interactions (Homo sapiens)
Syndecan-1 binds fibronectin (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
Syndecan-1:Fibronectin matrix [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
Integrin alpha5beta1 binds FN1 dimer (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
GPER1 signaling (Homo sapiens)
p-SHC1 binds integrin alpha5beta1:fibronectin (Homo sapiens)
Integrin alpha5beta1:Fibronectin matrix [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
integrin alpha5beta1:Fibronectin matrix:pY-SHC1 [plasma membrane] (Homo sapiens)
Integrin alpha5beta1:Fibronectin matrix [plasma membrane] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by MET (Homo sapiens)
MET promotes cell motility (Homo sapiens)
MET activates PTK2 signaling (Homo sapiens)
PTK2 binds activated MET (Homo sapiens)
Integrin alpha2beta1,alpha3:beta1:(collagen,laminin,fibronectin) [plasma membrane] (Homo sapiens)
Collagen, laminin, fibronectin [extracellular region] (Homo sapiens)
Fibronectin matrix [extracellular region] (Homo sapiens)
FN1 dimer [extracellular region] (Homo sapiens)
Participants
components
x 2
FN1(32-2477) [extracellular region]
(Homo sapiens)
Participates
as a candidate of
(FN1 dimer, VTN) [extracellular region] (Homo sapiens)
as a component of
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Homo sapiens)
as an input of
Integrin alpha5beta1 binds FN1 dimer (Homo sapiens)
as an output of
FN1 dimerizes (Homo sapiens)
as a repeated unit of
Fibronectin matrix [extracellular region] (Homo sapiens)
Inferred To
FN1 dimer [extracellular region]
(Bos taurus)
FN1 dimer [extracellular region]
(Caenorhabditis elegans)
FN1 dimer [extracellular region]
(Canis familiaris)
FN1 dimer [extracellular region]
(Danio rerio)
FN1 dimer [extracellular region]
(Dictyostelium discoideum)
FN1 dimer [extracellular region]
(Drosophila melanogaster)
FN1 dimer [extracellular region]
(Gallus gallus)
FN1 dimer [extracellular region]
(Mus musculus)
FN1 dimer [extracellular region]
(Rattus norvegicus)
FN1 dimer [extracellular region]
(Sus scrofa)
FN1 dimer [extracellular region]
(Xenopus tropicalis)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
