Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
MMP1 can degrade fibronectin (Fukai et al. 1995), as can MMP3 (Gunja-Smith et al. 1985, Nicholson et al. 1989, Wilhelm et al. 1993, Fukai et al. 1995), MMP7 (Quantin et al. 1989, Miyazaki et al. 1990, Fukai et al. 1995, von Bredow et al. 1995), MMP10 (Nicholson et al. 1989), MMP12 (Gronski et al. 1997), MMP13 (Knauper et al. 1997), MMP14 (Shi & Sottile 2011) and 19 (Stracke et al. 2000). Cathepsin S is able to degrade fibronectin (Taleb et al. 2006). Studies have shown that fibronectin turnover is not prevented by protease inhibitors (Sottile & Hocking 2002) suggesting that caveolin-1-mediated endocytosis and intracellular degradation are involved (Salicioni et al. 2002, Sottile & Chandler 2004).
Literature References
PubMed ID Title Journal Year
7547873 Release of biological activities from quiescent fibronectin by a conformational change and limited proteolysis by matrix metalloproteinases

Fukai, F, Yajima, H, Ohtaki, M, Miyazaki, K, Ishii, T, Katayama, T, Nishizawa, Y, Fujii, N

Biochemistry 1995
10809722 Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19. Evidence for a role as a potent basement membrane degrading enzyme

Murphy, G, Knäuper, V, López-Otin, C, Stracke, JO, Hutton, M, Stewart, M, Pendás, AM, Smith, B

J. Biol. Chem. 2000
16825321 Cathepsin s promotes human preadipocyte differentiation: possible involvement of fibronectin degradation

Taleb, S, Clément, K, Cancello, R, Lacasa, D

Endocrinology 2006
9115292 Hydrolysis of a broad spectrum of extracellular matrix proteins by human macrophage elastase

Kobayashi, DK, Gronski TJ, Jr, Martin, RL, Van Wart, HE, Holman, MC, Huber, M, Walsh, BC, Shapiro, SD

J Biol Chem 1997
9065415 The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction

O'Shea, M, Cowell, S, Morris, H, Smith, B, Zardi, L, López-Otin, C, Knäuper, V, Murphy, G

J Biol Chem 1997
Catalyst Activity

serine-type endopeptidase activity of MMP1, 3, 7, 12, 13, 19, CTSS [extracellular region]

Orthologous Events
Cite Us!