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AKR1C3 [cytosol]
Stable Identifier
R-HSA-2142714
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Aldo-keto reductase family 1 member C3, AK1C3_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Arachidonate metabolism (Homo sapiens)
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Homo sapiens)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Homo sapiens)
AKR1C3 [cytosol] (Homo sapiens)
PGH2 is reduced to PGF2a by AKR1C3 (Homo sapiens)
AKR1C3 [cytosol] (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Bile acid and bile salt metabolism (Homo sapiens)
Synthesis of bile acids and bile salts (Homo sapiens)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Homo sapiens)
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Homo sapiens)
Aldo-keto reductase family [cytosol] (Homo sapiens)
AKR1C3 [cytosol] (Homo sapiens)
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Homo sapiens)
Aldo-keto reductase family [cytosol] (Homo sapiens)
AKR1C3 [cytosol] (Homo sapiens)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Homo sapiens)
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Homo sapiens)
Aldo-keto reductase family [cytosol] (Homo sapiens)
AKR1C3 [cytosol] (Homo sapiens)
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Homo sapiens)
Aldo-keto reductase family [cytosol] (Homo sapiens)
AKR1C3 [cytosol] (Homo sapiens)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Homo sapiens)
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Homo sapiens)
Aldo-keto reductase family [cytosol] (Homo sapiens)
AKR1C3 [cytosol] (Homo sapiens)
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Homo sapiens)
Aldo-keto reductase family [cytosol] (Homo sapiens)
AKR1C3 [cytosol] (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of fat-soluble vitamins (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
AKRs reduce RBP2:atRAL to RBP2:atROL (Homo sapiens)
AKRs [cytosol] (Homo sapiens)
AKR1C3 [cytosol] (Homo sapiens)
Sensory Perception (Homo sapiens)
Visual phototransduction (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
AKRs reduce RBP2:atRAL to RBP2:atROL (Homo sapiens)
AKRs [cytosol] (Homo sapiens)
AKR1C3 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
Signaling by Retinoic Acid (Homo sapiens)
RA biosynthesis pathway (Homo sapiens)
AKR1C3 reduces atRAL to atROL (Homo sapiens)
AKR1C3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P42330 AKR1C3
Gene Names
AKR1C3, DDH1, HSD17B5, KIAA0119, PGFS
Chain
chain:1-323
Reference Genes
BioGPS Gene:8644 AKR1C3
COSMIC (genes):AKR1C3 AKR1C3
CTD Gene:8644 AKR1C3
dbSNP Gene:8644 AKR1C3
ENSEMBL:ENSG00000196139 AKR1C3
HGNC:386 AKR1C3
Monarch:8644 AKR1C3
NCBI Gene:8644 AKR1C3
OMIM:603966 AKR1C3
UCSC:P42330 AKR1C3
Reference Transcript
RefSeq:NM_003739.5 AKR1C3
RefSeq:NM_001253908.1 AKR1C3
Other Identifiers
11715711_a_at
11761156_at
16702007
209160_PM_at
209160_at
3233005
3233013
3233014
3233053
3233054
3233055
3233057
3233058
3233059
3233060
3233062
3233063
3233065
3233066
3233067
3233068
3233069
3233070
3233071
3233072
3233073
3233074
3233075
3233076
3233077
3233080
3233081
3233125
3233127
3274770
3274771
3274777
3274778
3274836
37399_at
7925929
8644
A_14_P113696
A_14_P200267
A_23_P138541
D17793_at
GE81317
GO:0001523
GO:0001758
GO:0003014
GO:0003824
GO:0004032
GO:0004033
GO:0004303
GO:0004745
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006629
GO:0006693
GO:0007186
GO:0007584
GO:0008202
GO:0008284
GO:0008584
GO:0009267
GO:0016488
GO:0016491
GO:0016655
GO:0019371
GO:0022414
GO:0030154
GO:0030216
GO:0032052
GO:0035410
GO:0036130
GO:0036131
GO:0042448
GO:0042572
GO:0042574
GO:0043170
GO:0043226
GO:0044597
GO:0044598
GO:0045550
GO:0045703
GO:0047017
GO:0047020
GO:0047023
GO:0047024
GO:0047035
GO:0047044
GO:0047045
GO:0047086
GO:0047787
GO:0048385
GO:0048856
GO:0051897
GO:0052650
GO:0061370
GO:0070062
GO:0070293
GO:0071277
GO:0071379
GO:0071384
GO:0071395
GO:0071799
GO:1900053
GO:1901135
GO:2000224
GO:2000353
GO:2000379
HMNXSV003014695
HMNXSV003053466
ILMN_1687757
ILMN_1713124
PH_hs_0028988
g187444_3p_s_at
g6624210_3p_at
Participates
as a member of
AKRs [cytosol] (Homo sapiens)
as a candidate of
Aldo-keto reductase family [cytosol] (Homo sapiens)
Inferred To
AKR1C1 [cytosol]
(Bos taurus)
AKR1C1 [cytosol]
(Mus musculus)
AKR1C1 [cytosol]
(Rattus norvegicus)
AKR1C1 [cytosol]
(Sus scrofa)
Homologues of AKR1C4 [cytosol]
(Caenorhabditis elegans)
Homologues of AKR1C4 [cytosol]
(Dictyostelium discoideum)
Homologues of AKR1C4 [cytosol]
(Drosophila melanogaster)
Homologues of AKR1C4 [cytosol]
(Saccharomyces cerevisiae)
Homologues of AKR1C4 [cytosol]
(Schizosaccharomyces pombe)
Homologues of AKR1C4 [cytosol]
(Xenopus tropicalis)
Homologues of AKR1C1 [cytosol]
(Bos taurus)
Homologues of AKR1C1 [cytosol]
(Mus musculus)
Homologues of AKR1C1 [cytosol]
(Rattus norvegicus)
Homologues of AKR1C1 [cytosol]
(Sus scrofa)
ARY [cytosol]
(Drosophila melanogaster)
AKR1C4 [cytosol]
(Bos taurus)
AKR1C4 [cytosol]
(Caenorhabditis elegans)
AKR1C4 [cytosol]
(Dictyostelium discoideum)
AKR1C4 [cytosol]
(Drosophila melanogaster)
AKR1C4 [cytosol]
(Mus musculus)
AKR1C4 [cytosol]
(Rattus norvegicus)
AKR1C4 [cytosol]
(Saccharomyces cerevisiae)
AKR1C4 [cytosol]
(Schizosaccharomyces pombe)
AKR1C4 [cytosol]
(Sus scrofa)
AKR1C4 [cytosol]
(Xenopus tropicalis)
Cross References
ZINC - World Drugs
AK1C3_HUMAN
Guide to Pharmacology - Targets
1382
OpenTargets
ENSG00000196139
ENSEMBL
ENST00000380554
,
ENSP00000369927
ZINC - FDA approved
AK1C3_HUMAN
ZINC - Substances
AK1C3_HUMAN
ZINC - Biogenic
AK1C3_HUMAN
ZINC target
P42330
PRO
P42330
GlyGen
P42330
PDB
4XVD
,
7C7F
,
7WQS
,
3R94
,
4XVE
,
8RB6
,
3R8H
,
6A7B
,
1RY0
,
4DBW
,
7WQM
,
4WDU
,
8JP1
,
1ZQ5
,
4DBS
,
4DBU
,
4FAM
,
2F38
,
1S2C
,
1RY8
,
5HNU
,
2FGB
,
1S1R
,
7X3L
,
3R7M
,
1XF0
,
3UFY
,
6F78
,
7C7G
,
4YVV
,
3R8G
,
8BBS
,
7WQR
,
3UG8
,
3UWE
,
4WDX
,
4WDW
,
4WDT
,
3UGR
,
8I0C
,
3R58
,
4WRH
,
3R6I
,
4ZFC
,
3R43
,
6GXK
,
1S2A
,
7X3O
,
1S1P
,
4H7C
,
6F2U
,
4YVX
,
4FAL
,
4HMN
,
7X3M
,
4FA3
,
4DZ5
,
5HNT
,
7C7H
ZINC - Metabolites
AK1C3_HUMAN
IntEnz
1.1.1.188
,
1.1.1.239
HPA
ENSG00000196139-AKR1C3
Pharos - Targets
P42330
ZINC - Predictions - Purchasable
AK1C3_HUMAN
HMDB Protein
HMDBP00360
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P17516 AKR1C4
1
AKR1C4 [cytosol]
(R-HSA-192142)
0.623
3
UniProt:Q04828 AKR1C1
1
AKR1C1 [cytosol]
(R-HSA-2855253)
0.527
2
UniProt:P51857 AKR1D1
1
AKR1D1 [cytosol]
(R-HSA-191975)
0.527
3
UniProt:P52895 AKR1C2
1
AKR1C2 [cytosol]
(R-HSA-3229259)
0.527
3
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