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AKR1D1 [cytosol]
Stable Identifier
R-HSA-191975
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
3-oxo-5-beta-steroid 4-dehydrogenase, AKD1_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Bile acid and bile salt metabolism (Homo sapiens)
Synthesis of bile acids and bile salts (Homo sapiens)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Homo sapiens)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Homo sapiens)
AKR1D1 [cytosol] (Homo sapiens)
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Homo sapiens)
AKR1D1 [cytosol] (Homo sapiens)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Homo sapiens)
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Homo sapiens)
AKR1D1 [cytosol] (Homo sapiens)
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Homo sapiens)
AKR1D1 [cytosol] (Homo sapiens)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Homo sapiens)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Homo sapiens)
AKR1D1 [cytosol] (Homo sapiens)
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Homo sapiens)
AKR1D1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51857 AKR1D1
Gene Names
AKR1D1, SRD5B1
Chain
chain:1-326
Reference Genes
BioGPS Gene:6718 AKR1D1
COSMIC (genes):AKR1D1 AKR1D1
CTD Gene:6718 AKR1D1
dbSNP Gene:6718 AKR1D1
ENSEMBL:ENSG00000122787 AKR1D1
ENSEMBL:ENSG00000122787.15 AKR1D1
HGNC:388 AKR1D1
KEGG Gene (Homo sapiens):6718 AKR1D1
Monarch:6718 AKR1D1
NCBI Gene:6718 AKR1D1
OMIM:604741 AKR1D1
UCSC:P51857 AKR1D1
Reference Transcript
RefSeq:NM_005989.3 AKR1D1
RefSeq:NM_001190907.1 AKR1D1
RefSeq:NM_001190906.1 AKR1D1
Other Identifiers
11735508_a_at
17052083
207102_PM_at
207102_at
3026504
3026505
3026506
3026508
3026509
3026511
3026512
3026514
3026516
3026517
3026519
3026520
3026523
3026525
3026526
34084_at
6718
8136459
A_23_P255185
A_23_P382000
GE62421
GO:0003824
GO:0004032
GO:0004033
GO:0005496
GO:0005737
GO:0005829
GO:0006629
GO:0006699
GO:0006707
GO:0007586
GO:0008202
GO:0008207
GO:0008209
GO:0008289
GO:0016042
GO:0016229
GO:0016491
GO:0030573
GO:0047086
GO:0047787
HMNXSV003026719
ILMN_1692661
ILMN_2157277
PH_hs_0011831
TC07000858.hg
Z28339_at
g5174694_3p_at
Inferred To
Homologues of AKR1D1 [cytosol]
(Caenorhabditis elegans)
Homologues of AKR1D1 [cytosol]
(Drosophila melanogaster)
Homologues of AKR1D1 [cytosol]
(Saccharomyces cerevisiae)
Homologues of AKR1D1 [cytosol]
(Schizosaccharomyces pombe)
ARY [cytosol]
(Drosophila melanogaster)
AKR1D1 [cytosol]
(Bos taurus)
AKR1D1 [cytosol]
(Caenorhabditis elegans)
AKR1D1 [cytosol]
(Canis familiaris)
AKR1D1 [cytosol]
(Dictyostelium discoideum)
AKR1D1 [cytosol]
(Drosophila melanogaster)
AKR1D1 [cytosol]
(Gallus gallus)
AKR1D1 [cytosol]
(Mus musculus)
AKR1D1 [cytosol]
(Rattus norvegicus)
AKR1D1 [cytosol]
(Saccharomyces cerevisiae)
AKR1D1 [cytosol]
(Schizosaccharomyces pombe)
AKR1D1 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001177836.1
,
NP_001177835.1
,
NP_005980.1
OpenTargets
ENSG00000122787
GeneCards
P51857
HPA
ENSG00000122787-AKR1D1
Ensembl
ENST00000242375
,
ENSP00000402374
,
ENSP00000389197
,
ENSP00000242375
,
ENSG00000122787
,
ENST00000411726
,
ENST00000432161
PRO
P51857
Pharos - Targets
P51857
Orphanet
16860
HMDB Protein
HMDBP00550
PDB
3DOP
,
3CAV
,
3COT
,
3BUR
,
3UZW
,
3UZZ
,
3BUV
,
3BV7
,
3CAS
,
3G1R
,
3CAQ
,
3UZY
,
3UZX
,
3CMF
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