Reactome | AKR1D1 [cytosol]

AKR1D1 [cytosol]

Stable Identifier

R-HSA-191975

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

3-oxo-5-beta-steroid 4-dehydrogenase, AKD1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P51857 AKR1D1

Gene Names

AKR1D1, SRD5B1

Chain

chain:1-326

Reference Genes

BioGPS Gene:6718 AKR1D1

COSMIC (genes):AKR1D1 AKR1D1

CTD Gene:6718 AKR1D1

dbSNP Gene:6718 AKR1D1

ENSEMBL:ENSG00000122787 AKR1D1

ENSEMBL_homo_sapiens_GENE:ENSG00000122787.15 AKR1D1

HGNC:388 AKR1D1

KEGG Gene (Homo sapiens):6718 AKR1D1

Monarch:6718 AKR1D1

NCBI Gene:6718 AKR1D1

OMIM:604741 AKR1D1

UCSC:P51857 AKR1D1

Reference Transcript

Other Identifiers

11735508_a_at

17052083

207102_PM_at

207102_at

3026504

3026505

3026506

3026508

3026509

3026511

3026512

3026514

3026516

3026517

3026519

3026520

3026523

3026525

3026526

34084_at

6718

8136459

A_23_P255185

A_23_P382000

GE62421

GO:0003824

GO:0004032

GO:0004033

GO:0005496

GO:0005737

GO:0005829

GO:0006629

GO:0006699

GO:0006707

GO:0007586

GO:0008202

GO:0008207

GO:0008209

GO:0008289

GO:0016042

GO:0016229

GO:0016491

GO:0030573

GO:0047086

GO:0047787

HMNXSV003026719

ILMN_1692661

ILMN_2157277

PH_hs_0011831

TC07000858.hg

Z28339_at

g5174694_3p_at

Inferred To

Homologues of AKR1D1 [cytosol] (Caenorhabditis elegans)

Homologues of AKR1D1 [cytosol] (Dictyostelium discoideum)

Homologues of AKR1D1 [cytosol] (Drosophila melanogaster)

Homologues of AKR1D1 [cytosol] (Saccharomyces cerevisiae)

Homologues of AKR1D1 [cytosol] (Schizosaccharomyces pombe)

ARY [cytosol] (Drosophila melanogaster)

AKR1D1 [cytosol] (Bos taurus)

AKR1D1 [cytosol] (Caenorhabditis elegans)

AKR1D1 [cytosol] (Canis familiaris)

AKR1D1 [cytosol] (Dictyostelium discoideum)

AKR1D1 [cytosol] (Drosophila melanogaster)

AKR1D1 [cytosol] (Gallus gallus)

AKR1D1 [cytosol] (Mus musculus)

AKR1D1 [cytosol] (Rattus norvegicus)

AKR1D1 [cytosol] (Saccharomyces cerevisiae)

AKR1D1 [cytosol] (Schizosaccharomyces pombe)

AKR1D1 [cytosol] (Sus scrofa)

AKR1D1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001177836.1, NP_001177835.1, NP_005980.1

OpenTargets

ENSG00000122787

GeneCards

P51857

HPA

ENSG00000122787-AKR1D1

Ensembl

ENST00000411726, ENSG00000122787, ENST00000432161, ENSP00000242375, ENSP00000389197, ENSP00000402374, ENST00000242375

PRO

P51857

Pharos - Targets

P51857

Orphanet

16860

HMDB Protein

HMDBP00550

PDB

3COT, 3UZY, 3UZX, 3DOP, 3CAS, 3BV7, 3BUV, 3CAQ, 3UZW, 3BUR, 3UZZ, 3G1R, 3CMF, 3CAV

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q04828 AKR1C1	1	AKR1C1 [cytosol] (R-HSA-2855253)	0.589	3
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.527	2
UniProt:O60218 AKR1B10	1	AKR1B10 [cytosol] (R-HSA-2855246)	0.527	2
UniProt:O95057 DIRA1			0.527	3
UniProt:P35414 APLNR	1	APLNR [plasma membrane] (R-HSA-374259)	0.527	2
UniProt:Q8TEQ6 GEMIN5	2	GEMIN5 [cytosol] (R-HSA-191833) GEMIN5 [nucleoplasm] (R-HSA-191765)	0.527	2
UniProt:P42330 AKR1C3	1	AKR1C3 [cytosol] (R-HSA-2142714)	0.527	3

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