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AKR1D1 [cytosol]
Stable Identifier
R-HSA-191975
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
3-oxo-5-beta-steroid 4-dehydrogenase, AKD1_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Bile acid and bile salt metabolism (Homo sapiens)
Synthesis of bile acids and bile salts (Homo sapiens)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Homo sapiens)
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Homo sapiens)
AKR1D1 [cytosol] (Homo sapiens)
4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Homo sapiens)
AKR1D1 [cytosol] (Homo sapiens)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Homo sapiens)
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Homo sapiens)
AKR1D1 [cytosol] (Homo sapiens)
4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Homo sapiens)
AKR1D1 [cytosol] (Homo sapiens)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Homo sapiens)
4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Homo sapiens)
AKR1D1 [cytosol] (Homo sapiens)
4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Homo sapiens)
AKR1D1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51857 AKR1D1
Gene Names
AKR1D1, SRD5B1
Chain
chain:1-326
Reference Genes
BioGPS Gene:6718 AKR1D1
COSMIC (genes):AKR1D1 AKR1D1
CTD Gene:6718 AKR1D1
dbSNP Gene:6718 AKR1D1
ENSEMBL:ENSG00000122787 AKR1D1
ENSEMBL_homo_sapiens_GENE:ENSG00000122787 AKR1D1
HGNC:388 AKR1D1
KEGG Gene (Homo sapiens):6718 AKR1D1
Monarch:6718 AKR1D1
NCBI Gene:6718 AKR1D1
OMIM:604741 AKR1D1
UCSC:P51857 AKR1D1
Reference Transcript
RefSeq:NM_001190906.1 AKR1D1
RefSeq:NM_001190907.1 AKR1D1
RefSeq:NM_005989.3 AKR1D1
Other Identifiers
0006180524
11735508_a_at
17052083
3026504
3026505
3026506
3026508
3026509
3026511
3026512
3026514
3026516
3026517
3026519
3026520
3026523
3026525
3026526
3BUR
3BUV
3BV7
3CAQ
3CAS
3CAV
3CMF
3COT
3DOP
3G1R
3UZW
3UZX
3UZY
3UZZ
57002
6718
8136459
A_23_P255185
A_23_P382000
AAG39381
AAI30626
AAI30628
AC009263
AC024082
AC083867
AF283651
AF283652
AF283653
AF283654
AF283655
AF283656
AF283657
AF283658
AF283659
AK289425
AK298421
AK298428
AKR1D1
AKR1D1-201
AKR1D1-202
AKR1D1-203
BAF82114
BAG60645
BAG60650
BC130625
BC130627
C9J3U1
CAA82193
CCDS55169
CCDS55170
CCDS5846
CH236950
CH471070
EAL24049
EAW83881
ENSG00000122787
ENSP00000242375
ENSP00000389197
ENSP00000402374
ENST00000242375
ENST00000411726
ENST00000432161
EntrezGene:6718
GE62421
GO:0003674
GO:0004032
GO:0004033
GO:0005496
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005829
GO:0006629
GO:0006699
GO:0006707
GO:0007586
GO:0008106
GO:0008150
GO:0008202
GO:0008207
GO:0008209
GO:0008289
GO:0009056
GO:0009058
GO:0016042
GO:0016229
GO:0016491
GO:0030573
GO:0044281
GO:0047086
GO:0047787
GO:0055114
HGNC:388
HPA057002
ILMN_1692661
IPR018170
IPR020471
IPR023210
IPR036812
MIM:235555
MIM:604741
NM_001190906
NM_001190907
NM_005989
NP_001177835
NP_001177836
NP_005980
PF00248
PH_hs_0011831
PR00069
uc003vtz.4
uc011kqe.2
uc011kqf.3
UPI0000125764
UPI00017A769E
UPI00017A76A3
Z28339
Inferred To
Homologues of AKR1D1 [cytosol] (Arabidopsis thaliana)
Homologues of AKR1D1 [cytosol] (Canis familiaris)
Homologues of AKR1D1 [cytosol] (Dictyostelium discoideum)
Homologues of AKR1D1 [cytosol] (Drosophila melanogaster)
Homologues of AKR1D1 [cytosol] (Gallus gallus)
Homologues of AKR1D1 [cytosol] (Oryza sativa)
Homologues of AKR1D1 [cytosol] (Rattus norvegicus)
Homologues of AKR1D1 [cytosol] (Schizosaccharomyces pombe)
AKR1D1 [cytosol] (Arabidopsis thaliana)
AKR1D1 [cytosol] (Bos taurus)
AKR1D1 [cytosol] (Canis familiaris)
AKR1D1 [cytosol] (Dictyostelium discoideum)
AKR1D1 [cytosol] (Drosophila melanogaster)
AKR1D1 [cytosol] (Gallus gallus)
AKR1D1 [cytosol] (Mus musculus)
AKR1D1 [cytosol] (Oryza sativa)
AKR1D1 [cytosol] (Rattus norvegicus)
AKR1D1 [cytosol] (Schizosaccharomyces pombe)
AKR1D1 [cytosol] (Sus scrofa)
AKR1D1 [cytosol] (Taeniopygia guttata)
AKR1D1 [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_001177836.1
,
NP_005980.1
,
NP_001177835.1
OpenTargets
ENSG00000122787
GeneCards
P51857
DOCK Blaster
3CAV
,
3UZZ
,
3BUR
,
3DOP
,
3UZX
,
3CMF
,
3COT
,
3UZY
,
3CAS
,
3BV7
,
3BUV
,
3CAQ
,
3G1R
,
3UZW
PRO
P51857
BRENDA (Homo sapiens)
1.3.1.3
Orphanet
16860
PDB
3UZY
,
3CMF
,
3UZX
,
3COT
,
3CAV
,
3BUR
,
3DOP
,
3UZW
,
3UZZ
,
3CAQ
,
3CAS
,
3BV7
,
3BUV
,
3G1R
HMDB Protein
HMDBP00550
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