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AKR1C4 [cytosol]
Stable Identifier
R-HSA-192142
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Aldo-keto reductase family 1 member C4, AKC4_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Bile acid and bile salt metabolism (Homo sapiens)
Synthesis of bile acids and bile salts (Homo sapiens)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Homo sapiens)
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Homo sapiens)
Aldo-keto reductase family [cytosol] (Homo sapiens)
AKR1C4 [cytosol] (Homo sapiens)
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Homo sapiens)
Aldo-keto reductase family [cytosol] (Homo sapiens)
AKR1C4 [cytosol] (Homo sapiens)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Homo sapiens)
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Homo sapiens)
Aldo-keto reductase family [cytosol] (Homo sapiens)
AKR1C4 [cytosol] (Homo sapiens)
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Homo sapiens)
Aldo-keto reductase family [cytosol] (Homo sapiens)
AKR1C4 [cytosol] (Homo sapiens)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Homo sapiens)
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Homo sapiens)
Aldo-keto reductase family [cytosol] (Homo sapiens)
AKR1C4 [cytosol] (Homo sapiens)
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Homo sapiens)
Aldo-keto reductase family [cytosol] (Homo sapiens)
AKR1C4 [cytosol] (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of fat-soluble vitamins (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
AKRs reduce RBP2:atRAL to RBP2:atROL (Homo sapiens)
AKRs [cytosol] (Homo sapiens)
AKR1C4 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Visual phototransduction (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
AKRs reduce RBP2:atRAL to RBP2:atROL (Homo sapiens)
AKRs [cytosol] (Homo sapiens)
AKR1C4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P17516 AKR1C4
Gene Names
AKR1C4, CHDR
Chain
chain:1-323
Reference Genes
BioGPS Gene:1109 AKR1C4
COSMIC (genes):AKR1C4 AKR1C4
CTD Gene:1109 AKR1C4
dbSNP Gene:1109 AKR1C4
ENSEMBL:ENSG00000198610 AKR1C4
HGNC:387 AKR1C4
KEGG Gene (Homo sapiens):1109 AKR1C4
Monarch:1109 AKR1C4
NCBI Gene:1109 AKR1C4
OMIM:600451 AKR1C4
UCSC:P17516 AKR1C4
Reference Transcript
RefSeq:NM_001818.3 AKR1C4
Other Identifiers
0000460398
1109
11731677_at
16702026
210558_at
3233005
3233012
3233063
3233120
3233121
3233123
3233124
3233125
3233126
3233127
3233128
3233129
3233130
3233132
3233133
3233134
3233136
3233137
3233138
3274778
3274835
35482_at
7925939
A_23_P149926
A_33_P3272291
GE80629
GO:0001523
GO:0001758
GO:0003674
GO:0004032
GO:0004033
GO:0005496
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005829
GO:0006091
GO:0006629
GO:0006693
GO:0006699
GO:0006810
GO:0008106
GO:0008150
GO:0008202
GO:0008207
GO:0008209
GO:0008289
GO:0009055
GO:0009058
GO:0015125
GO:0015721
GO:0016229
GO:0016491
GO:0016655
GO:0019748
GO:0022857
GO:0022900
GO:0032052
GO:0042448
GO:0043167
GO:0043226
GO:0044281
GO:0044597
GO:0044598
GO:0047023
GO:0047086
GO:0047743
GO:0051186
GO:0055114
GO:0070062
GO:0071395
ILMN_1668880
ILMN_1687757
PH_hs_0010556
S68287_at
TC10000044.hg
g9186907_3p_at
Participant Of
hasMember
AKRs [cytosol]
Aldo-keto reductase family [cytosol]
Inferred To
dyrk3 [cytosol] (Xenopus tropicalis)
Homologues of AKR1C4 [cytosol] (Bos taurus)
Homologues of AKR1C4 [cytosol] (Caenorhabditis elegans)
Homologues of AKR1C4 [cytosol] (Drosophila melanogaster)
Homologues of AKR1C4 [cytosol] (Mus musculus)
Homologues of AKR1C4 [cytosol] (Rattus norvegicus)
Homologues of AKR1C4 [cytosol] (Schizosaccharomyces pombe)
Homologues of AKR1C4 [cytosol] (Xenopus tropicalis)
LOC782061 [cytosol] (Bos taurus)
exc-15 [cytosol] (Caenorhabditis elegans)
Akr1c6 [cytosol] (Mus musculus)
Akr1c1 [cytosol] (Rattus norvegicus)
Dmel\CG6083 [cytosol] (Drosophila melanogaster)
LOC527068 [cytosol] (Bos taurus)
Akr1c14 [cytosol] (Mus musculus)
Akr1c9 [cytosol] (Rattus norvegicus)
Akr1cl [cytosol] (Mus musculus)
glb1 [cytosol] (Xenopus tropicalis)
AKR1C4 [cytosol] (Bos taurus)
AKR1C4 [cytosol] (Caenorhabditis elegans)
AKR1C4 [cytosol] (Plasmodium falciparum)
AKR1C4 [cytosol] (Schizosaccharomyces pombe)
AKR1C4 [cytosol] (Xenopus tropicalis)
Akr1c20 [cytosol] (Mus musculus)
LOC785762 [cytosol] (Bos taurus)
Akr1c21 [cytosol] (Mus musculus)
Akr1c21 [cytosol] (Rattus norvegicus)
LOC782884 [cytosol] (Bos taurus)
rpe65 [cytosol] (Xenopus tropicalis)
LOC506594 [cytosol] (Bos taurus)
RGD1564865 [cytosol] (Rattus norvegicus)
Akr1B [cytosol] (Drosophila melanogaster)
AKR1C3 [cytosol] (Canis familiaris)
AKR1C3 [cytosol] (Sus scrofa)
LOC538060 [cytosol] (Bos taurus)
Akr1c18 [cytosol] (Mus musculus)
Akr1c18 [cytosol] (Rattus norvegicus)
cdkn1a [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_001809.3
OpenTargets
ENSG00000198610
ZINC - Substances
AK1C4_HUMAN
ZINC - Biogenic
AK1C4_HUMAN
ZINC target
P17516
PRO
P17516
PDB
2FVL
IntEnz
1.1.1.357
,
1.1.1.225
GeneCards
P17516
HPA
ENSG00000198610-AKR1C4
Ensembl
ENST00000263126
,
ENSP00000263126
,
ENST00000380448
,
ENSG00000198610
,
ENSP00000369814
Orphanet
20809
ZINC - Predictions - Purchasable
AK1C4_HUMAN
HMDB Protein
HMDBP00074
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