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AKR1C2 [cytosol]
Stable Identifier
R-HSA-3229259
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Aldo-keto reductase family 1 member C2 ecNumber1.-.-.-/ecNumber, AK1C2_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Bile acid and bile salt metabolism (Homo sapiens)
Synthesis of bile acids and bile salts (Homo sapiens)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Homo sapiens)
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Homo sapiens)
Aldo-keto reductase family [cytosol] (Homo sapiens)
AKR1C2 [cytosol] (Homo sapiens)
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Homo sapiens)
Aldo-keto reductase family [cytosol] (Homo sapiens)
AKR1C2 [cytosol] (Homo sapiens)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Homo sapiens)
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Homo sapiens)
Aldo-keto reductase family [cytosol] (Homo sapiens)
AKR1C2 [cytosol] (Homo sapiens)
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Homo sapiens)
Aldo-keto reductase family [cytosol] (Homo sapiens)
AKR1C2 [cytosol] (Homo sapiens)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Homo sapiens)
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Homo sapiens)
Aldo-keto reductase family [cytosol] (Homo sapiens)
AKR1C2 [cytosol] (Homo sapiens)
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Homo sapiens)
Aldo-keto reductase family [cytosol] (Homo sapiens)
AKR1C2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P52895 AKR1C2
Gene Names
AKR1C2, DDH2
Chain
chain:1-323
Reference Genes
BioGPS Gene:1646 AKR1C2
COSMIC (genes):AKR1C2 AKR1C2
CTD Gene:1646 AKR1C2
dbSNP Gene:1646 AKR1C2
ENSEMBL:ENSG00000151632 AKR1C2
HGNC:385 AKR1C2
Monarch:1646 AKR1C2
NCBI Gene:1646 AKR1C2
OMIM:600450 AKR1C2
UCSC:P52895 AKR1C2
Reference Transcript
RefSeq:NM_001135241.2 AKR1C2
RefSeq:NM_205845.2 AKR1C2
RefSeq:NM_001354.5 AKR1C2
Other Identifiers
11729101_a_at
11738244_s_at
11738245_x_at
11754189_s_at
11761068_s_at
11761114_x_at
1555854_PM_at
1555854_at
1646
16711343
204151_3p_x_at
204151_PM_x_at
204151_x_at
209699_PM_x_at
209699_x_at
211653_3p_x_at
211653_PM_x_at
211653_x_at
216594_3p_x_at
216594_PM_x_at
216594_x_at
244266_PM_at
244266_at
3232991
3232992
3232993
3232994
3232998
3233000
3233005
3233006
3233007
3233009
3233012
3233013
3233014
3233015
3233018
3233020
3233022
3233063
3233074
3233075
3233127
3274763
3274764
3274765
3274769
3274770
3274771
3274772
3274773
3274775
3274776
3274777
3274778
3274779
3274782
3274783
3274784
3274785
3274786
3274787
3274788
3274789
3274812
3274814
3274820
3274821
3274822
3274824
32805_at
42985_r_at
60814_at
61427_at
7931832
8180376
A_24_P220947
A_24_P312578
A_33_P3403708
GE80398
GE86136
GO:0003824
GO:0004032
GO:0004303
GO:0005737
GO:0005829
GO:0006629
GO:0006693
GO:0007186
GO:0007586
GO:0008202
GO:0008284
GO:0016491
GO:0016655
GO:0030154
GO:0030855
GO:0031406
GO:0032052
GO:0042448
GO:0044597
GO:0044598
GO:0047023
GO:0047044
GO:0047086
GO:0047115
GO:0047718
GO:0051897
GO:0071395
GO:0071799
GO:1901135
HMNXSV003023750
HMNXSV003047732
HMNXSV003053466
HMNXSV003054128
Hs.306098.1.S1_3p_s_at
Hs.98729.0.A1_3p_at
Hs2.213397.1.A1_3p_at
ILMN_1668617
ILMN_1719154
ILMN_1730191
ILMN_2412336
PH_hs_0029424
PH_hs_0040868
TC10000986.hg
U05861_at
g187444_3p_s_at
g187444_3p_x_at
g531159_3p_at
g5453542_3p_s_at
Participates
as a candidate of
Aldo-keto reductase family [cytosol] (Homo sapiens)
Inferred To
AKR1C1 [cytosol]
(Bos taurus)
AKR1C1 [cytosol]
(Mus musculus)
AKR1C1 [cytosol]
(Rattus norvegicus)
AKR1C1 [cytosol]
(Sus scrofa)
Homologues of AKR1C4 [cytosol]
(Caenorhabditis elegans)
Homologues of AKR1C4 [cytosol]
(Dictyostelium discoideum)
Homologues of AKR1C4 [cytosol]
(Drosophila melanogaster)
Homologues of AKR1C4 [cytosol]
(Saccharomyces cerevisiae)
Homologues of AKR1C4 [cytosol]
(Schizosaccharomyces pombe)
Homologues of AKR1C4 [cytosol]
(Xenopus tropicalis)
Homologues of AKR1C1 [cytosol]
(Bos taurus)
Homologues of AKR1C1 [cytosol]
(Mus musculus)
Homologues of AKR1C1 [cytosol]
(Rattus norvegicus)
Homologues of AKR1C1 [cytosol]
(Sus scrofa)
ARY [cytosol]
(Drosophila melanogaster)
AKR1C4 [cytosol]
(Bos taurus)
AKR1C4 [cytosol]
(Caenorhabditis elegans)
AKR1C4 [cytosol]
(Dictyostelium discoideum)
AKR1C4 [cytosol]
(Drosophila melanogaster)
AKR1C4 [cytosol]
(Mus musculus)
AKR1C4 [cytosol]
(Rattus norvegicus)
AKR1C4 [cytosol]
(Saccharomyces cerevisiae)
AKR1C4 [cytosol]
(Schizosaccharomyces pombe)
AKR1C4 [cytosol]
(Sus scrofa)
AKR1C4 [cytosol]
(Xenopus tropicalis)
Cross References
ZINC - World Drugs
AK1C2_HUMAN
OpenTargets
ENSG00000151632
ENSEMBL
ENST00000380753
,
ENST00000455190
,
ENSP00000370129
,
ENSP00000408440
ZINC - FDA approved
AK1C2_HUMAN
ZINC - Substances
AK1C2_HUMAN
ZINC - Biogenic
AK1C2_HUMAN
ZINC target
P52895
PRO
P52895
PDB
4XO6
,
4JQ3
,
4JQA
,
1J96
,
4JQ4
,
4JTQ
,
4XO7
,
2IPJ
,
1XJB
,
4JTR
,
4JQ2
,
4L1X
,
4JQ1
,
1IHI
,
4L1W
,
2HDJ
ZINC - Metabolites
AK1C2_HUMAN
HPA
ENSG00000151632-AKR1C2
Pharos - Targets
P52895
ZINC - Predictions - Purchasable
AK1C2_HUMAN
Orphanet
AKR1C2
HMDB Protein
HMDBP00387
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q04828 AKR1C1
1
AKR1C1 [cytosol]
(R-HSA-2855253)
0.527
3
UniProt:P42330 AKR1C3
1
AKR1C3 [cytosol]
(R-HSA-2142714)
0.527
3
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