Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
AKR1C3 [cytosol]
Stable Identifier
R-CFA-192142
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
AKR1C4, A0A8I3MRB2
Locations in the PathwayBrowser
Expand all
Drug ADME (Canis familiaris)
Prednisone ADME (Canis familiaris)
AKR1C1 hydrogenates PREDN,PREDL (Canis familiaris)
AKR1C3 [cytosol] (Canis familiaris)
Metabolism (Canis familiaris)
Metabolism of lipids (Canis familiaris)
Fatty acid metabolism (Canis familiaris)
Arachidonate metabolism (Canis familiaris)
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Canis familiaris)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Canis familiaris)
AKR1C3 [cytosol] (Canis familiaris)
PGH2 is reduced to PGF2a by AKR1C3 (Canis familiaris)
AKR1C3 [cytosol] (Canis familiaris)
Metabolism of steroids (Canis familiaris)
Bile acid and bile salt metabolism (Canis familiaris)
Synthesis of bile acids and bile salts (Canis familiaris)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Canis familiaris)
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Canis familiaris)
AKR1C3 [cytosol] (Canis familiaris)
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Canis familiaris)
AKR1C3 [cytosol] (Canis familiaris)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Canis familiaris)
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Canis familiaris)
AKR1C3 [cytosol] (Canis familiaris)
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Canis familiaris)
AKR1C3 [cytosol] (Canis familiaris)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Canis familiaris)
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Canis familiaris)
AKR1C3 [cytosol] (Canis familiaris)
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Canis familiaris)
AKR1C3 [cytosol] (Canis familiaris)
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of fat-soluble vitamins (Canis familiaris)
Retinoid metabolism and transport (Canis familiaris)
AKRs reduce RBP2:atRAL to RBP2:atROL (Canis familiaris)
AKR1C3 [cytosol] (Canis familiaris)
Sensory Perception (Canis familiaris)
Visual phototransduction (Canis familiaris)
Retinoid metabolism and transport (Canis familiaris)
AKRs reduce RBP2:atRAL to RBP2:atROL (Canis familiaris)
AKR1C3 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by Nuclear Receptors (Canis familiaris)
Signaling by Retinoic Acid (Canis familiaris)
RA biosynthesis pathway (Canis familiaris)
AKR1C3 reduces atRAL to atROL (Canis familiaris)
AKR1C3 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3MRB2
Gene Names
AKR1C3
Reference Genes
BioGPS Gene:497070 AKR1C3
ENSEMBL:ENSCAFG00845002994.1
Monarch:497070 AKR1C3
NCBI Gene:497070 AKR1C3
UCSC:A0A8I3MRB2 AKR1C3
Reference Transcript
RefSeq:XM_038657848.1 AKR1C3
RefSeq:XM_038657847.1 AKR1C3
Other Identifiers
497070
Cfa.16463.1.S1_at
CfaAffx.8885.1.S1_s_at
GO:0016491
Inferred From
AKRs [cytosol]
(Homo sapiens)
Aldo-keto reductase family [cytosol]
(Homo sapiens)
AKR1C4 [cytosol]
(Homo sapiens)
AKR1C1 [cytosol]
(Homo sapiens)
AKR1C2 [cytosol]
(Homo sapiens)
AKR1C3 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_038513776.1
,
XP_038513775.1
ENSEMBL
ENSCAFP00845004208
,
ENSCAFG00845002994
,
ENSCAFT00845005292
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
