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Eicosanoids
Stable Identifier
R-HSA-211979
Type
Pathway
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
,
endoplasmic reticulum lumen
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Eicosanoids (Homo sapiens)
General
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Arachidonic acid is metabolized via three major enzymatic pathways: cyclooxygenase, lipoxygenase, and cytochrome P450. The cytochrome P450 pathway metabolites are oxygenated metabolites of arachidonic acid.
Literature References
PubMed ID
Title
Journal
Year
7922394
Prostaglandins, thromboxanes, leukotrienes, and cytochrome P-450 metabolites of arachidonic acid
Geisel, J
,
Cook, JA
,
Halushka, PV
,
Reines, HD
New Horiz
1993
15102545
57 varieties: the human cytochromes P450
Lewis, DF
Pharmacogenomics
2004
16584116
Cytochrome P450s and other enzymes in drug metabolism and toxicity
Guengerich, FP
AAPS J
2006
Participants
Events
CYP4F2, 4F3 20-hydroxylate LTB4
(Homo sapiens)
CYP4F3 20-hydroxylates LTB4
(Homo sapiens)
CYP4F8 19-hydroxylates PGH2
(Homo sapiens)
TBXAS1 isomerises PGH2 to TXA2
(Homo sapiens)
PTGIS, CYP8A1 isomerise PGH2 to PGI2
(Homo sapiens)
CYP4F22 20-hydroxylates TrXA3
(Homo sapiens)
Participates
as an event of
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Event Information
Go Biological Process
icosanoid metabolic process (0006690)
Orthologous Events
Eicosanoids (Bos taurus)
Eicosanoids (Canis familiaris)
Eicosanoids (Danio rerio)
Eicosanoids (Gallus gallus)
Eicosanoids (Mus musculus)
Eicosanoids (Rattus norvegicus)
Eicosanoids (Sus scrofa)
Eicosanoids (Xenopus tropicalis)
Authored
Jassal, B (2008-05-19)
Reviewed
D'Eustachio, P (2008-05-28)
Created
Jassal, B (2008-02-08)
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