CYP4F3 20-hydroxylates LTB4

Stable Identifier
R-HSA-215526
Type
Reaction [transition]
Species
Homo sapiens
Compartment
smooth endoplasmic reticulum
ReviewStatus
5/5
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CYP4F3 20-hydroxylates LTB4
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Leukotriene B4 (LTB4) is formed from arachidonic acid and is a potent inflammatory mediator. LTB4's activity is terminated by formation of its omega hydroxylated metabolite, 20-hydroxyleukotriene B4 (20OH-LTB4). This deactivation can be carried out by CYP4F3 in addition to CYP4F2 (Kikuta et al. 1998).
Literature References
PubMed ID Title Journal Year
9539102 Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular cloning and chromosomal localization

Kikuta, Y, Kato, M, Yamashita, Y, Miyauchi, Y, Tanaka, K, Kamada, N, Kusunose, M

DNA Cell Biol 1998
Participants
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Output
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as an event of
Catalyst Activity

monooxygenase activity of Cytochrome P450 (CYP4F3 based) [endoplasmic reticulum membrane]

Physical Entity
Cytochrome P450 (CYP4F3 based) [endoplasmic reticulum membrane] (Homo sapiens)
Activity
monooxygenase activity (GO:0004497)
Orthologous Events
CYP4F3 20-hydroxylates LTB4 (Bos taurus)
CYP4F3 20-hydroxylates LTB4 (Canis familiaris)
CYP4F3 20-hydroxylates LTB4 (Danio rerio)
CYP4F3 20-hydroxylates LTB4 (Drosophila melanogaster)
CYP4F3 20-hydroxylates LTB4 (Gallus gallus)
CYP4F3 20-hydroxylates LTB4 (Mus musculus)
CYP4F3 20-hydroxylates LTB4 (Rattus norvegicus)
CYP4F3 20-hydroxylates LTB4 (Sus scrofa)
CYP4F3 20-hydroxylates LTB4 (Xenopus tropicalis)
Authored
Jassal, B  (2008-05-19)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2008-03-04)
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