CYP4F3 20-hydroxylates LTB4

Stable Identifier
R-HSA-215526
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Leukotriene B4 (LTB4) is formed from arachidonic acid and is a potent inflammatory mediator. LTB4's activity is terminated by formation of its omega hydroxylated metabolite, 20-hydroxyleukotriene B4 (20OH-LTB4). This deactivation can be carried out by CYP4F3 in addition to CYP4F2 (Kikuta et al. 1998).

Literature References
PubMed ID Title Journal Year
9539102 Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular cloning and chromosomal localization

Kikuta, Y, Kato, M, Yamashita, Y, Miyauchi, Y, Tanaka, K, Kamada, N, Kusunose, M

DNA Cell Biol 1998
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hasEvent
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of Cytochrome P450 (CYP4F3 based) [endoplasmic reticulum membrane]
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Activity
Orthologous Events
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