Reactome | TBXAS1 isomerises PGH2 to TXA2

TBXAS1 isomerises PGH2 to TXA2

Stable Identifier

R-HSA-76500

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, endoplasmic reticulum lumen

Synonyms

rostaglandin H2 => thromboxane A2, Thromboxane synthase (CYP5A1) mediates the isomerization of prostaglandin H2 to thromboxane A2

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Biological oxidations (Homo sapiens)
  - Phase I - Functionalization of compounds (Homo sapiens)
    - Cytochrome P450 - arranged by substrate type (Homo sapiens)
      - Eicosanoids (Homo sapiens)
        
        TBXAS1 isomerises PGH2 to TXA2 (Homo sapiens)
- Metabolism of lipids (Homo sapiens)
  - Fatty acid metabolism (Homo sapiens)
    - Arachidonate metabolism (Homo sapiens)
      - Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Homo sapiens)
        
        TBXAS1 isomerises PGH2 to TXA2 (Homo sapiens)

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Thromboxane synthase (TBXAS1) aka CYP5A1 mediates the isomerisation of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2) (Miyata et al. 2001, Chevalier et al. 2001). This reaction is not coupled with any P450 reductase proteins nor consumes NADPH.

Literature References

PubMed ID	Title	Journal	Year
7925341	Characterization of the human gene (TBXAS1) encoding thromboxane synthase Miyata, A, Yokoyama, C, Ihara, H, Bandoh, S, Takeda, O, Takahashi, E, Tanabe, T	Eur J Biochem	1994
11465543	Identification of genetic variants in the human thromboxane synthase gene (CYP5A1) Chevalier, D, Lo-Guidice, JM, Sergent, E, Allorge, D, Debuysère, H, Ferrari, N, Libersa, C, Lhermitte, M, Broly, F	Mutat Res	2001