TBXAS1 isomerises PGH2 to TXA2

Stable Identifier
R-HSA-76500
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Thromboxane synthase (CYP5A1) mediates the isomerization of prostaglandin H2 to thromboxane A2
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Thromboxane synthase (TBXAS1) aka CYP5A1 mediates the isomerisation of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2) (Miyata et al. 2001, Chevalier et al. 2001). This reaction is not coupled with any P450 reductase proteins nor consumes NADPH.

Literature References
PubMed ID Title Journal Year
11465543 Identification of genetic variants in the human thromboxane synthase gene (CYP5A1)

Chevalier, D, Lo-Guidice, JM, Sergent, E, Allorge, D, Debuysère, H, Ferrari, N, Libersa, C, Lhermitte, M, Broly, F

Mutat Res 2001
7925341 Characterization of the human gene (TBXAS1) encoding thromboxane synthase

Miyata, A, Yokoyama, C, Ihara, H, Bandoh, S, Takeda, O, Takahashi, E, Tanabe, T

Eur J Biochem 1994
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thromboxane-A synthase activity of TBXAS1 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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