CYP4F8 19-hydroxylates PGH2

Stable Identifier
R-HSA-211919
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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19-hydroxyprostaglandins E1 and E2 (19OH-PGE1 and 2) are major components of human seminal fluid. The initial step in their formation is the 19-hydroxylation of prostaglandin H1 and H2 (PGH1 and 2). CYP4F8 performs this initial conversion (Bylund et al. 1999, 2000). The example of PGH2 is used here.

Literature References
PubMed ID Title Journal Year
10405341 Gene expression of a novel cytochrome P450 of the CYP4F subfamily in human seminal vesicles

Bylund, J, Finnström, N, Oliw, EH

Biochem Biophys Res Commun 1999
10791960 Identification of CYP4F8 in human seminal vesicles as a prominent 19-hydroxylase of prostaglandin endoperoxides

Bylund, J, Hidestrand, M, Ingelman-Sundberg, M, Oliw, EH

J Biol Chem 2000
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of Cytochrome P450 (CYP4F8 based) [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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Created