CYP4F8 19-hydroxylates PGH2

Stable Identifier
R-HSA-211919
Type
Reaction [transition]
Species
Homo sapiens
Compartment
smooth endoplasmic reticulum
ReviewStatus
5/5
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CYP4F8 19-hydroxylates PGH2
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19-hydroxyprostaglandins E1 and E2 (19OH-PGE1 and 2) are major components of human seminal fluid. The initial step in their formation is the 19-hydroxylation of prostaglandin H1 and H2 (PGH1 and 2). CYP4F8 performs this initial conversion (Bylund et al. 1999, 2000). The example of PGH2 is used here.
Literature References
PubMed ID Title Journal Year
10791960 Identification of CYP4F8 in human seminal vesicles as a prominent 19-hydroxylase of prostaglandin endoperoxides

Bylund, J, Hidestrand, M, Ingelman-Sundberg, M, Oliw, EH

J Biol Chem 2000
10405341 Gene expression of a novel cytochrome P450 of the CYP4F subfamily in human seminal vesicles

Bylund, J, Finnström, N, Oliw, EH

Biochem Biophys Res Commun 1999
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Catalyst Activity

monooxygenase activity of Cytochrome P450 (CYP4F8 based) [endoplasmic reticulum membrane]

Physical Entity
Cytochrome P450 (CYP4F8 based) [endoplasmic reticulum membrane] (Homo sapiens)
Activity
monooxygenase activity (GO:0004497)
Orthologous Events
CYP4F8 19-hydroxylates PGH2 (Bos taurus)
CYP4F8 19-hydroxylates PGH2 (Canis familiaris)
CYP4F8 19-hydroxylates PGH2 (Danio rerio)
CYP4F8 19-hydroxylates PGH2 (Mus musculus)
CYP4F8 19-hydroxylates PGH2 (Rattus norvegicus)
CYP4F8 19-hydroxylates PGH2 (Sus scrofa)
CYP4F8 19-hydroxylates PGH2 (Xenopus tropicalis)
Authored
Jassal, B  (2008-05-19)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2008-02-08)
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