CYP4F22 20-hydroxylates TrXA3

Stable Identifier
R-HSA-5602295
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytochrome P450 4F22 (CYP4F22) is thought to 20-hydroxylate trioxilin A3 (TrXA3), an intermediary metabolite from the 12(R)-lipoxygenase pathway. This pathway is implicated in proliferative skin diseases. The major products of arachidonic acid in keratinocytes are 12- and 15-HETE which undergo biotransformation to products involved in skin hydration. CYP4F22 mutations can lead to autosomal recessive congenital ichthyosis (ARCI) (Lefevre et al. 2006).

Literature References
PubMed ID Title Journal Year
16436457 Mutations in a new cytochrome P450 gene in lamellar ichthyosis type 3

Lefevre, C, Bouadjar, B, Ferrand, V, Tadini, G, Megarbane, A, Lathrop, M, Prud'homme, JF, Fischer, J

Hum Mol Genet 2006
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of CYP4F22 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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