Reactome | CYP4F22 20-hydroxylates TrXA3

CYP4F22 20-hydroxylates TrXA3

Stable Identifier

R-HSA-5602295

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytochrome P450 4F22 (CYP4F22) is thought to 20-hydroxylate trioxilin A3 (TrXA3), an intermediary metabolite from the 12(R)-lipoxygenase pathway. This pathway is implicated in proliferative skin diseases. The major products of arachidonic acid in keratinocytes are 12- and 15-HETE which undergo biotransformation to products involved in skin hydration. CYP4F22 mutations can lead to autosomal recessive congenital ichthyosis (ARCI) (Lefevre et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16436457	Mutations in a new cytochrome P450 gene in lamellar ichthyosis type 3 Tadini, G, Lefevre, C, Ferrand, V, Prud'homme, JF, Lathrop, M, Fischer, J, Megarbane, A, Bouadjar, B	Hum Mol Genet	2006