PTGIS, CYP8A1 isomerise PGH2 to PGI2

Stable Identifier
R-HSA-76496
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Prostacyclin synthase (CYP8A1) mediates the isomerization of prostaglandin H2 to prostaglandin I2
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Prostacyclin synthase (PTGIS) aka CYP8A1 mediates the isomerisation of prostaglandin H2 (PGH2) to prostaglandin I2 (PGI2) aka prostacyclin (Wada et al. 2004). This reaction is not coupled with any P450 reductase proteins nor consumes NADPH. Experiments on rats with thrombolytic models suggest endogenous MNA could be a stimulator of the COX2/PGI2 pathway and thus regulate an anti-thrombotic effect (Chlopicki et al. 2007).

Literature References
PubMed ID Title Journal Year
15115769 Purification and characterization of recombinant human prostacyclin synthase

Wada, M, Yokoyama, C, Hatae, T, Shimonishi, M, Nakamura, M, Imai, Y, Ullrich, V, Tanabe, T

J Biochem 2004
17641676 1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway

Chlopicki, S, Swies, J, Mogielnicki, A, Buczko, W, Bartus, M, Lomnicka, M, Adamus, J, Gebicki, J

Br. J. Pharmacol. 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
prostaglandin-I synthase activity of PTGIS,CYP8B1 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created