Reactome | PTGIS, CYP8A1 isomerise PGH2 to PGI2

PTGIS, CYP8A1 isomerise PGH2 to PGI2

Stable Identifier

R-HSA-76496

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, endoplasmic reticulum lumen

Synonyms

prostaglandin H2 => prostaglandin I2, Prostacyclin synthase (CYP8A1) mediates the isomerization of prostaglandin H2 to prostaglandin I2

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Biological oxidations (Homo sapiens)
  - Phase I - Functionalization of compounds (Homo sapiens)
    - Cytochrome P450 - arranged by substrate type (Homo sapiens)
      - Eicosanoids (Homo sapiens)
        
        PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Homo sapiens)
- Metabolism of lipids (Homo sapiens)
  - Fatty acid metabolism (Homo sapiens)
    - Arachidonate metabolism (Homo sapiens)
      - Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Homo sapiens)
        
        PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Homo sapiens)
- Metabolism of vitamins and cofactors (Homo sapiens)
  - Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
    - Nicotinate metabolism (Homo sapiens)
      - Nicotinamide salvaging (Homo sapiens)
        
        PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Homo sapiens)

General

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Prostacyclin synthase (PTGIS) aka CYP8A1 mediates the isomerisation of prostaglandin H2 (PGH2) to prostaglandin I2 (PGI2) aka prostacyclin (Wada et al. 2004). This reaction is not coupled with any P450 reductase proteins nor consumes NADPH. Experiments on rats with thrombolytic models suggest endogenous MNA could be a stimulator of the COX2/PGI2 pathway and thus regulate an anti-thrombotic effect (Chlopicki et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17641676	1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway Chlopicki, S, Lomnicka, M, Bartus, M, Swies, J, Mogielnicki, A, Gebicki, J, Buczko, W, Adamus, J	Br. J. Pharmacol.	2007
15115769	Purification and characterization of recombinant human prostacyclin synthase Shimonishi, M, Yokoyama, C, Imai, Y, Ullrich, V, Nakamura, M, Hatae, T, Tanabe, T, Wada, M	J Biochem	2004