Prostacyclin synthase (PTGIS) aka CYP8A1 mediates the isomerisation of prostaglandin H2 (PGH2) to prostaglandin I2 (PGI2) aka prostacyclin (Wada et al. 2004). This reaction is not coupled with any P450 reductase proteins nor consumes NADPH. Experiments on rats with thrombolytic models suggest endogenous MNA could be a stimulator of the COX2/PGI2 pathway and thus regulate an anti-thrombotic effect (Chlopicki et al. 2007).
Chlopicki, S, Lomnicka, M, Bartus, M, Swies, J, Mogielnicki, A, Gebicki, J, Buczko, W, Adamus, J
Shimonishi, M, Yokoyama, C, Imai, Y, Ullrich, V, Nakamura, M, Hatae, T, Tanabe, T, Wada, M
prostaglandin-I synthase activity of PTGIS,CYP8B1 [endoplasmic reticulum membrane]
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