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p-S-ITGA5 [plasma membrane]
Stable Identifier
R-HSA-9857662
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
fullName evidence="27"Integrin alpha-5, ITA5_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes (Homo sapiens)
p-S-ITGA5:ITGB1 binds p-S373-GJA1 (Homo sapiens)
p-S-ITGA5:ITGB1 [plasma membrane] (Homo sapiens)
p-S-ITGA5 [plasma membrane] (Homo sapiens)
p-S373-GJA1:p-S-ITGA5:ITGB1 [plasma membrane] (Homo sapiens)
p-S-ITGA5:ITGB1 [plasma membrane] (Homo sapiens)
p-S-ITGA5 [plasma membrane] (Homo sapiens)
p-S373-GJA1:p-S-ITGA5:ITGB1 (p-S373-Connexin-43:p-S-Integrin alpha5:Integrin beta1) transports ATP from the cytosol to the extracellular region (Homo sapiens)
p-S373-GJA1:p-S-ITGA5:ITGB1 [plasma membrane] (Homo sapiens)
p-S-ITGA5:ITGB1 [plasma membrane] (Homo sapiens)
p-S-ITGA5 [plasma membrane] (Homo sapiens)
p-S373-GJA1:p-S-ITGA5:ITGB1 (p-S373-Connexin-43:p-S-Integrin alpha5:Integrin beta1) transports prostaglandin E2 (PGE2) from the cytosol to the extracellular region (Homo sapiens)
p-S373-GJA1:p-S-ITGA5:ITGB1 [plasma membrane] (Homo sapiens)
p-S-ITGA5:ITGB1 [plasma membrane] (Homo sapiens)
p-S-ITGA5 [plasma membrane] (Homo sapiens)
p-T308,S473-AKT1 phosphorylates ITGA5 (Integrin alpha5) in ITGA5:ITGB1 (Integrin alpha5:Integrin beta1) (Homo sapiens)
p-S-ITGA5:ITGB1 [plasma membrane] (Homo sapiens)
p-S-ITGA5 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08648 ITGA5
Gene Names
ITGA5, FNRA
Chain
signal peptide:1-41, chain:42-1049, chain:42-894, chain:895-1049
Reference Genes
BioGPS Gene:3678 ITGA5
COSMIC (genes):ITGA5 ITGA5
CTD Gene:3678 ITGA5
dbSNP Gene:3678 ITGA5
ENSEMBL:ENSG00000161638 ITGA5
HGNC:6141 ITGA5
KEGG:hsa:3678 ITGA5
Monarch:3678 ITGA5
NCBI Gene:3678 ITGA5
OMIM:135620 ITGA5
UCSC:P08648 ITGA5
Reference Transcript
RefSeq:NM_002205.5 ITGA5
Other Identifiers
11715702_at
11715703_s_at
11715704_x_at
11748449_a_at
16765558
201389_PM_at
201389_at
3456733
3456734
3456735
3456736
3456737
3456738
3456739
3456740
3456741
3456742
3456743
3456744
3456745
3456746
3456747
3456748
3456749
3456750
3456751
3456752
3456753
3456754
3456755
3456756
3456757
3456758
3456759
3456760
3456762
3456763
3456765
3456766
3456767
3456768
3456769
3456770
3456772
3456774
3456775
3456780
3456781
3456782
3678
39753_at
7963786
A_23_P36562
GE59678
GO:0001525
GO:0001618
GO:0001726
GO:0005161
GO:0005178
GO:0005509
GO:0005515
GO:0005783
GO:0005794
GO:0005886
GO:0005911
GO:0005925
GO:0007044
GO:0007155
GO:0007157
GO:0007159
GO:0007160
GO:0007229
GO:0007613
GO:0008305
GO:0009897
GO:0009986
GO:0014850
GO:0016020
GO:0023035
GO:0030154
GO:0030949
GO:0031410
GO:0031589
GO:0032587
GO:0033627
GO:0033631
GO:0034113
GO:0034330
GO:0034674
GO:0035313
GO:0035987
GO:0038023
GO:0043184
GO:0043226
GO:0045202
GO:0045765
GO:0046718
GO:0046872
GO:0048870
GO:0050877
GO:0060089
GO:0070161
GO:0071062
GO:0098609
GO:1900748
GO:1903672
GO:2000811
ILMN_1792679
PH_hs_0009005
TC12001571.hg
X06256_at
g4504750_3p_at
Participates
as a component of
p-S-ITGA5:ITGB1 [plasma membrane] (Homo sapiens)
Other forms of this molecule
ITGA5(42-894) [plasma membrane]
ITGA5 [plasma membrane]
Modified Residues
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_002196.4
Guide to Pharmacology - Targets
2444
OpenTargets
ENSG00000161638
ENSEMBL
ENSG00000161638
,
ENST00000293379
,
ENSP00000293379
HPA
ENSG00000161638-ITGA5
GeneCards
ITGA5
PRO
P08648
Pharos - Targets
P08648
GlyGen
P08648
PDB
4WJK
,
9CKV
,
4WK2
,
4WK0
,
3VI4
,
7NWL
,
3VI3
,
7NXD
,
4WK4
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05556 ITGB1
2
ITGB1 [plasma membrane]
(R-HSA-57596)
ITGB1 [endosome membrane]
(R-HSA-9611157)
0.908
9
UniProt:P02751 FN1
10
FN1(32-2477) [extracellular region]
(R-HSA-54851)
FN1 [endoplasmic reticulum lumen]
(R-HSA-8956708)
p-FN1 [endoplasmic reticulum lumen]
(R-HSA-8956937)
FN1(32-2477) [platelet alpha granule lumen]
(R-HSA-114620)
FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane]
(R-HSA-9713459)
FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane]
(R-HSA-9713462)
FN1(?-2386) [extracellular region]
(R-HSA-2533841)
FN1(32-?) [extracellular region]
(R-HSA-2533850)
FN1(272-2386) [extracellular region]
(R-HSA-3788024)
FN1(32-271) [extracellular region]
(R-HSA-3787935)
0.839
11
UniProt:Q9H0F6 SHARPIN
1
SHARPIN [cytosol]
(R-HSA-5212666)
0.602
4
UniProt:P17813 EGLN
0.556
4
UniProt:P97333 Nrp1
1
Nrp1 [plasma membrane]
(R-MMU-421085)
0.544
3
UniProt:P17931 LGALS3
3
LGALS3 [plasma membrane]
(R-HSA-879445)
LGALS3 [secretory granule membrane]
(R-HSA-6803327)
LGALS3 [ficolin-1-rich granule membrane]
(R-HSA-6803307)
0.527
2
UniProt:Q96LR4 TAFA4
0.527
2
UniProt:P09382 LGALS1
2
LGALS1 [endoplasmic reticulum lumen]
(R-HSA-8956711)
p-LGALS1 [endoplasmic reticulum lumen]
(R-HSA-8957003)
0.527
3
UniProt:Q9UK22 FBXO2
1
FBXO2 [cytosol]
(R-HSA-976044)
0.527
3
UniProt:O00214 LEG8
0.527
3
UniProt:P60033 CD81
1
CD81 [plasma membrane]
(R-HSA-197933)
0.527
5
UniProt:Q8TC27 ADA32
0.527
2
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