Reactome | NGF [cytosol]

NGF [cytosol]

Stable Identifier

R-CFA-190059

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

NGF, A0A8I3PYI3

Locations in the PathwayBrowser

Expand all

Signal Transduction (Canis familiaris)

- Signaling by Receptor Tyrosine Kinases (Canis familiaris)
  - Signaling by NTRKs (Canis familiaris)
    - Signaling by NTRK1 (TRKA) (Canis familiaris)
      - Activation of TRKA receptors (Canis familiaris)
        
        TRKA activation by NGF (Canis familiaris)
        
        Activated TrkA receptor internalizes to endosomes (Canis familiaris)
        
        Activated TrkA receptor complex [endosome membrane] (Canis familiaris)
        
        beta-NGF homodimer [cytosol] (Canis familiaris)
        
        NGF [cytosol] (Canis familiaris)
      - Signalling to ERKs (Canis familiaris)
        
        Prolonged ERK activation events (Canis familiaris)
        
        Frs2-mediated activation (Canis familiaris)
        
        FRS2 binds to active TrkA receptor (Canis familiaris)
        
        Activated TrkA receptor complex [endosome membrane] (Canis familiaris)
        
        beta-NGF homodimer [cytosol] (Canis familiaris)
        
        NGF [cytosol] (Canis familiaris)
        
        Active TrkA receptor:FRS2 complex [endosome membrane] (Canis familiaris)
        
        Activated TrkA receptor complex [endosome membrane] (Canis familiaris)
        
        beta-NGF homodimer [cytosol] (Canis familiaris)
        
        NGF [cytosol] (Canis familiaris)
        
        FRS2 is phosphorylated by active TrkA receptor (Canis familiaris)
        
        Active TrkA receptor:FRS2 complex [endosome membrane] (Canis familiaris)
        
        Activated TrkA receptor complex [endosome membrane] (Canis familiaris)
        
        beta-NGF homodimer [cytosol] (Canis familiaris)
        
        NGF [cytosol] (Canis familiaris)
        
        Active TrkA receptor:p-FRS2 complex [endosome membrane] (Canis familiaris)
        
        Activated TrkA receptor complex [endosome membrane] (Canis familiaris)
        
        beta-NGF homodimer [cytosol] (Canis familiaris)
        
        NGF [cytosol] (Canis familiaris)
        
        p-FRS2:CRKL binds C3G (Canis familiaris)
        
        Active TrkA receptor:p-FRS2:CRKL complex [endosome membrane] (Canis familiaris)
        
        Activated TrkA receptor complex [endosome membrane] (Canis familiaris)
        
        beta-NGF homodimer [cytosol] (Canis familiaris)
        
        NGF [cytosol] (Canis familiaris)
        
        Active TrkA receptor:p-FRS2:CRKL:RAPGEF1 [endosome membrane] (Canis familiaris)
        
        Active TrkA receptor:p-FRS2:CRKL complex [endosome membrane] (Canis familiaris)
        
        Activated TrkA receptor complex [endosome membrane] (Canis familiaris)
        
        beta-NGF homodimer [cytosol] (Canis familiaris)
        
        NGF [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3PYI3

Gene Names

NGF

Reference Genes

BioGPS Gene:403402 NGF

ENSEMBL:ENSCAFG00845027859.1

KEGG:cfa:403402 NGF

Monarch:403402 NGF

NCBI Gene:403402 NGF

UCSC:A0A8I3PYI3 NGF

Reference Transcript

Other Identifiers

403402

Cfa.3899.1.S1_s_at

CfaAffx.15276.1.S1_at

GO:0004857

GO:0005102

GO:0005163

GO:0005576

GO:0007422

GO:0007623

GO:0008083

GO:0008191

GO:0008625

GO:0010628

GO:0010976

GO:0014042

GO:0019233

GO:0030297

GO:0030414

GO:0031175

GO:0031398

GO:0038180

GO:0043524

GO:0045664

GO:0045773

GO:0046579

GO:0046928

GO:0048011

GO:0048018

GO:0048672

GO:0048675

GO:0048812

GO:0048856

GO:0050877

GO:0051279

GO:0051402

GO:0051897

GO:0070374

GO:0097192

GO:0098772

Participates

as a component of

beta-NGF homodimer [cytosol] (Canis familiaris)

Other forms of this molecule

NGF [extracellular region]

NGF [Golgi lumen]

NGF [extracellular region]

Inferred From

NGF [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_038546347.1, NP_001181879.1

ENSEMBL

ENSCAFP00845038559, ENSCAFT00845049144, ENSCAFG00845027859