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SORT1 [Golgi membrane]
Stable Identifier
R-HSA-434332
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi membrane
Synonyms
Sortilin, SORT_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
trans-Golgi Network Vesicle Budding (Homo sapiens)
Golgi Associated Vesicle Biogenesis (Homo sapiens)
Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Homo sapiens)
Cargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp Complex [Golgi membrane] (Homo sapiens)
Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
SORT1 [Golgi membrane] (Homo sapiens)
Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
SORT1 [Golgi membrane] (Homo sapiens)
trans-Golgi Network Coat Assembly (Homo sapiens)
Cargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp Complex [Golgi membrane] (Homo sapiens)
Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
SORT1 [Golgi membrane] (Homo sapiens)
Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex [Golgi membrane] (Homo sapiens)
Cargo:AP-1:beta-Arrestin-1:Vamp Complex [Golgi membrane] (Homo sapiens)
Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
SORT1 [Golgi membrane] (Homo sapiens)
trans-Golgi Network Vesicle Scission (Homo sapiens)
Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex [Golgi membrane] (Homo sapiens)
Cargo:AP-1:beta-Arrestin-1:Vamp Complex [Golgi membrane] (Homo sapiens)
Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
SORT1 [Golgi membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99523 SORT1
Gene Names
SORT1
Chain
signal peptide:1-33, propeptide:34-77, chain:78-831
Reference Genes
BioGPS Gene:6272 SORT1
COSMIC (genes):SORT1 SORT1
CTD Gene:6272 SORT1
dbSNP Gene:6272 SORT1
ENSEMBL:ENSG00000134243 SORT1
ENSEMBL_homo_sapiens_GENE:ENSG00000134243.12 SORT1
HGNC:11186 SORT1
KEGG Gene (Homo sapiens):6272 SORT1
Monarch:6272 SORT1
NCBI Gene:6272 SORT1
OMIM:602458 SORT1
UCSC:Q99523 SORT1
Reference Transcript
RefSeq:NM_001205228.1 SORT1
RefSeq:NM_002959.6 SORT1
Other Identifiers
11727007_at
11727008_at
11746408_a_at
16690566
212797_PM_at
212797_at
212807_PM_s_at
212807_s_at
224818_PM_at
224818_at
2427004
2427005
2427006
2427008
2427009
2427010
2427011
2427012
2427013
2427014
2427015
2427016
2427017
2427018
2427019
2427020
2427021
2427023
2427024
2427030
2427033
2427035
2427036
2427037
2427038
2427039
2427040
2427041
2427042
2427044
2427045
2427046
2427047
2427050
2427051
2427053
2427062
2427063
2427069
2427070
2427071
2427072
2427073
43352_s_at
6272
65737_r_at
74769_s_at
7918323
87868_at
A_23_P201587
A_24_P325520
GE86120
GO:0001503
GO:0005515
GO:0005634
GO:0005635
GO:0005764
GO:0005765
GO:0005768
GO:0005769
GO:0005773
GO:0005783
GO:0005789
GO:0005794
GO:0005829
GO:0005886
GO:0005905
GO:0006622
GO:0006886
GO:0006895
GO:0006897
GO:0007186
GO:0007218
GO:0008333
GO:0008625
GO:0009986
GO:0010008
GO:0010465
GO:0010468
GO:0012501
GO:0014902
GO:0016020
GO:0016050
GO:0016192
GO:0019899
GO:0023052
GO:0030136
GO:0030140
GO:0030154
GO:0030379
GO:0030659
GO:0031410
GO:0031965
GO:0032509
GO:0032580
GO:0032868
GO:0034330
GO:0038180
GO:0043226
GO:0045599
GO:0046323
GO:0048011
GO:0048227
GO:0048406
GO:0048471
GO:0048856
GO:0051005
GO:0055085
GO:0060089
GO:0090160
GO:0099558
GO:0150053
GO:1905394
HMNXSV003021085
Hs.180372.0.S1_3p_at
Hs.281706.1.A1_3p_a_at
Hs.281706.1.A2_3p_at
ILMN_1707077
PH_hs_0024551
PH_hs_0033102
TC01002954.hg
Participates
as a candidate of
Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
Other forms of this molecule
SORT1 [cytoplasmic vesicle membrane]
Inferred To
VTH2 [Golgi membrane]
(Saccharomyces cerevisiae)
SORT1 [Golgi membrane]
(Bos taurus)
SORT1 [Golgi membrane]
(Canis familiaris)
SORT1 [Golgi membrane]
(Gallus gallus)
SORT1 [Golgi membrane]
(Saccharomyces cerevisiae)
SORT1 [Golgi membrane]
(Sus scrofa)
PEP1 [Golgi membrane]
(Saccharomyces cerevisiae)
Sort1 [Golgi membrane]
(Mus musculus)
Sort1 [Golgi membrane]
(Rattus norvegicus)
VTH1 [Golgi membrane]
(Saccharomyces cerevisiae)
Homologues of SORT1 [Golgi membrane]
(Saccharomyces cerevisiae)
sort1 [Golgi membrane]
(Dictyostelium discoideum)
sort1 [Golgi membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001192157.1
,
NP_002950.3
OpenTargets
ENSG00000134243
ZINC - Substances
SORT_HUMAN
ZINC target
Q99523
PRO
Q99523
PDB
6X3L
,
4MSL
,
3G2V
,
5MRI
,
6X48
,
3G2U
,
4N7E
,
3F6K
,
4PO7
,
6EHO
,
5MRH
,
6X4H
ZINC - Investigational
SORT_HUMAN
HPA
ENSG00000134243-SORT1
GeneCards
Q99523
Ensembl
ENST00000256637
,
ENST00000538502
,
ENSP00000438597
,
ENSG00000134243
,
ENSP00000256637
Pharos - Targets
Q99523
ZINC - Predictions - Purchasable
SORT_HUMAN
HMDB Protein
HMDBP10753
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01138 NGF
7
NGF(19-241) [extracellular region]
(R-HSA-187033)
NGF [Golgi lumen]
(R-HSA-166515)
NGF [cytosol]
(R-HSA-190059)
NGF(1-241) [endoplasmic reticulum lumen]
(R-HSA-187026)
NGF(19-241) [Golgi lumen]
(R-HSA-187036)
NGF(19-241) [endoplasmic reticulum lumen]
(R-HSA-187047)
NGF [extracellular region]
(R-HSA-167034)
0.676
5
UniProt:P11151
1
LPL [extracellular region]
(R-BTA-174605)
0.659
6
UniProt:P30990 NTS
3
NTS(151-160) [extracellular region]
(R-HSA-8940947)
NTS(161-163) [extracellular region]
(R-HSA-8940954)
NTS(151-163) [extracellular region]
(R-HSA-388915)
0.609
2
UniProt:P26441 CNTF
1
CNTF [extracellular region]
(R-HSA-5696441)
0.571
6
UniProt:P05231 IL6
3
IL6 [extracellular region]
(R-HSA-447100)
IL6 [endoplasmic reticulum lumen]
(R-HSA-8956764)
p-IL6 [endoplasmic reticulum lumen]
(R-HSA-8957044)
0.571
4
UniProt:P24941 CDK2
5
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
CDK2 [cytosol]
(R-HSA-157440)
CDK2 [nucleoplasm]
(R-HSA-68365)
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
0.564
2
UniProt:P02787 TF
6
apoTF [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869140)
TF [secretory granule lumen]
(R-HSA-350704)
apoTF [extracellular region]
(R-HSA-350754)
apoTF [endosome membrane]
(R-HSA-917974)
p-TF [endoplasmic reticulum lumen]
(R-HSA-8957001)
TF [endoplasmic reticulum lumen]
(R-HSA-8956763)
0.556
3
UniProt:Q9JLC4 Sorcs1
1
Sorcs1 [Golgi membrane]
(R-MMU-8931817)
0.544
2
UniProt:Q16288 NTRK3
6
NTRK3(32-495) [plasma membrane]
(R-HSA-9603541)
NTRK3(642-839) [cytosol]
(R-HSA-9603540)
NTRK3(496-641) [mitochondrial outer membrane]
(R-HSA-9603557)
NTRK3(496-641) [cytosol]
(R-HSA-9603542)
NTRK3 [plasma membrane]
(R-HSA-6798240)
p-5Y-NTRK3 [plasma membrane]
(R-HSA-9034718)
0.544
2
UniProt:P42702 LIFR
1
LIFR [plasma membrane]
(R-HSA-5693181)
0.506
3
UniProt:P04629 NTRK1
4
p-5Y-NTRK1 [Golgi membrane]
(R-HSA-3008810)
NTRK1 [Golgi membrane]
(R-HSA-3008805)
NTRK1 [plasma membrane]
(R-HSA-3008784)
p-5Y-NTRK1 [plasma membrane]
(R-HSA-3009413)
0.463
3
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