Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CCNA:p-T160-CDK2 [nucleoplasm]
Stable Identifier
R-HSA-187952
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cyclin A:phospho-Cdk2(Thr160) complex
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 (Homo sapiens)
Cyclin E/A:p-T160-CDK2:CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Ubiquitination of phospho-p27/p21 (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2 Phase (Homo sapiens)
Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2:E2F1/E2F3 [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Homo sapiens)
CCNA:p-T160-CDK2:E2F1/E2F3 [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2:p-E2F1/p-E2F3 [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
G2/M Transition (Homo sapiens)
Cyclin A/B1/B2 associated events during G2/M transition (Homo sapiens)
CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Homo sapiens)
p-CDK1/2:CCNA/p-T161-CDK1:CCNB1 [nucleoplasm] (Homo sapiens)
CCNA:p-CDK1/2 [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
Association of Cyclin A:Cdk2 with Cdh1 (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Homo sapiens)
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
CAK-mediated phosphorylation of Cyclin A:Cdk2 (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 (Homo sapiens)
Cyclin E/A:p-T160-CDK2:CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Ubiquitination of phospho-p27/p21 (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
CDK-mediated phosphorylation and removal of Cdc6 (Homo sapiens)
Cdc6 protein is phosphorylated by CDK (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Telomere Maintenance (Homo sapiens)
Extension of Telomeres (Homo sapiens)
Telomere Extension By Telomerase (Homo sapiens)
CDK2:CCNA phosphorylates TERF2 (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Recruitment of Telomerase RNP to the Telomeric Chromosome End (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Senescence-Associated Secretory Phenotype (SASP) (Homo sapiens)
CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Homo sapiens)
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
Processing of DNA double-strand break ends (Homo sapiens)
CDK2 phosphorylates RBBP8 (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8 [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
MRN complex binds CDK2 and RBBP8 (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8 [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
CDK-mediated phosphorylation and removal of Cdc6 (Homo sapiens)
Cdc6 protein is phosphorylated by CDK (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
CDK2 phosphorylates TP53 (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Regulation of TP53 Expression and Degradation (Homo sapiens)
Regulation of TP53 Degradation (Homo sapiens)
(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Homo sapiens)
CCNA:p-CDK1/2 [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Participants
components
CCNA [nucleoplasm]
(Homo sapiens)
p-T160-CDK2 [nucleoplasm]
(Homo sapiens)
Participates
as an input of
CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Homo sapiens)
Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Homo sapiens)
Association of Cyclin A:Cdk2 with Cdh1 (Homo sapiens)
MRN complex binds CDK2 and RBBP8 (Homo sapiens)
as a component of
CCNA:p-T160-CDK2:p-E2F1/p-E2F3 [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2:E2F1/E2F3 [nucleoplasm] (Homo sapiens)
Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8 [nucleoplasm] (Homo sapiens)
as a member of
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
CCNA:p-CDK1/2 [nucleoplasm] (Homo sapiens)
as an output of
CAK-mediated phosphorylation of Cyclin A:Cdk2 (Homo sapiens)
CDK2 phosphorylates RBBP8 (Homo sapiens)
This entity regulates
Negatively
Recruitment of Telomerase RNP to the Telomeric Chromosome End
(Homo sapiens)
Inferred To
CCNA:p-T160-CDK2 [nucleoplasm]
(Bos taurus)
CCNA:p-T160-CDK2 [nucleoplasm]
(Caenorhabditis elegans)
CCNA:p-T160-CDK2 [nucleoplasm]
(Canis familiaris)
CCNA:p-T160-CDK2 [nucleoplasm]
(Danio rerio)
CCNA:p-T160-CDK2 [nucleoplasm]
(Dictyostelium discoideum)
CCNA:p-T160-CDK2 [nucleoplasm]
(Drosophila melanogaster)
CCNA:p-T160-CDK2 [nucleoplasm]
(Gallus gallus)
CCNA:p-T160-CDK2 [nucleoplasm]
(Mus musculus)
CCNA:p-T160-CDK2 [nucleoplasm]
(Rattus norvegicus)
CCNA:p-T160-CDK2 [nucleoplasm]
(Schizosaccharomyces pombe)
CCNA:p-T160-CDK2 [nucleoplasm]
(Sus scrofa)
CCNA:p-T160-CDK2 [nucleoplasm]
(Xenopus tropicalis)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
