In the S/G2 phase of the cell cycle, CDK2:CCNA (CDK2:cyclin A) complex and CtIP (RBBP8) are recruited to DNA double-strand breaks (DSBs) by the MRN complex. RBBP8 interacts with NBN (NBS1) and RAD50 subunits, while CDK2:CCNA interacts with the MRE11A subunit of the complex (Buis et al. 2012). RBBP8 functions as a homotetramer (Davies et al. 2015).
Morton, CR, Forment, JV, Pellegrini, L, Jackson, SP, Coates, J, Galanty, Y, Belotserkovskaya, R, Demir, M, Sun, M, Davies, OR, Rzechorzek, NJ
Stoneham, T, Buis, J, Spehalski, E, Ferguson, DO
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