Reactome | CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1

CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1

Stable Identifier

R-HSA-3788708

Type

Reaction

Species

Homo sapiens

Compartment

nucleoplasm

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CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1

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Cyclin A-Cdk2 (CCNA:CDK2) prevents unscheduled APC reactivation during S phase by binding and subsequently phosphorylating FZR1 (Cdh1). Phosphorylation-dependent dissociation of the Cdh1-activating subunit inhibits the APC/C (Sorensen et al. 2001). DNA damage activates ATM kinase, resulting in TP53-mediated induction of CDKN1A (p21) expression. CDKN1A binds CCNA:CDK2 complex and prevents its association with Cdh1 (Takahashi et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
11340163	A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression Lukas, J, Peters, JM, Kramer, ER, Sorensen, CS, Lukas, C	Mol Cell Biol	2001
22178396	DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells Peters, G, Yoshimoto, S, Shinkai, Y, Imai, Y, Tachibana, M, Takahashi, A, Saya, H, Takeuchi, T, Hori, S, Hara, E, Kuninaka, S, Yamakoshi, K, Ohtani, N, Anderton, E	Mol. Cell	2012