Reactome | CCNA:p-T160-CDK2 [nucleoplasm]

CCNA:p-T160-CDK2 [nucleoplasm]

Stable Identifier

R-RNO-187952

Type

Complex

Species

Rattus norvegicus

Compartment

nucleoplasm

Locations in the PathwayBrowser

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General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

CCNA [nucleoplasm] (Rattus norvegicus)
phospho-p-T160-CDK2 [nucleoplasm] (Rattus norvegicus)

Participates

as an input of

CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Rattus norvegicus)
Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Rattus norvegicus)
Association of Cyclin A:Cdk2 with Cdh1 (Rattus norvegicus)
MRN complex binds CDK2 and RBBP8 (Rattus norvegicus)

as a component of

CCNA:p-T160-CDK2:p-E2F1/p-E2F3 [nucleoplasm] (Rattus norvegicus)
CCNA:p-T160-CDK2:E2F1/E2F3 [nucleoplasm] (Rattus norvegicus)
Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Rattus norvegicus)
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Rattus norvegicus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8 [nucleoplasm] (Rattus norvegicus)

as an output of

CAK-mediated phosphorylation of Cyclin A:Cdk2 (Rattus norvegicus)
CDK2 phosphorylates RBBP8 (Rattus norvegicus)

as a member of

CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Rattus norvegicus)
CCNA:p-CDK1/2 [nucleoplasm] (Rattus norvegicus)

This entity regulates

Negatively

Recruitment of Telomerase RNP to the Telomeric Chromosome End (Rattus norvegicus)

Inferred From

CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)

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