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About
What is Reactome ?
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Digital Preservation
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TERF2 [nucleoplasm]
Stable Identifier
R-HSA-174895
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
TRF2
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Telomere Maintenance (Homo sapiens)
Extension of Telomeres (Homo sapiens)
Telomere C-strand (Lagging Strand) Synthesis (Homo sapiens)
Disassociation of Processive Complex and Completed Telomere End (Homo sapiens)
Extended And Processed Telomere End [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:ligated C-strand Okazaki fragments [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Polymerase switching on the C-strand of the telomere (Homo sapiens)
Formation of Processive Complex on the C-strand of the telomere (Homo sapiens)
Processive complex loaded on telomere [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
RFC binding displaces Pol Alpha on the C-strand of the telomere (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
RNA primer:DNA primer:G-strand extended telomere:POLA:primase [nucleoplasm] (Homo sapiens)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
RFC dissociates after sliding clamp formation on the C-strand of the telomere (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Processive synthesis on the C-strand of the telomere (Homo sapiens)
Formation of C-strand Okazaki fragments (Homo sapiens)
Processive complex loaded on telomere [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Formation of the Flap Intermediate on the C-strand (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Joining of adjacent Okazaki fragments of the C-strand (Homo sapiens)
Processive complex loaded on telomere:ligated C-strand Okazaki fragments [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Removal of the Flap Intermediate from the C-strand (Homo sapiens)
RPA binds to the Flap on the C-strand (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Recruitment of DNA2 endonuclease to the C strand (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:DNA2 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:DNA2 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragments:Remaining Flap [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Removal of remaining Flap from the C-strand (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragments:Remaining Flap [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Telomere C-strand synthesis initiation (Homo sapiens)
DNA polymerase:primase binds G-strand of the telomere (Homo sapiens)
POLA:primase:G-strand extended telomere end [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Telomeric G-strand chromosome end with two additional single strand repeats [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Homo sapiens)
RNA primer:DNA primer:G-strand extended telomere:POLA:primase [nucleoplasm] (Homo sapiens)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Homo sapiens)
POLA:primase:G-strand extended telomere end [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Telomere Extension By Telomerase (Homo sapiens)
Alignment Of The RNA Template On The Telomeric Chromosome End (Homo sapiens)
Telomerase RNP Bound and base-paired to the Telomeric Chromosome End [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Telomerase RNP:G-strand telomeric chromosome end [nucleoplasm] (Homo sapiens)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
CDK2:CCNA phosphorylates TERF2 (Homo sapiens)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Disassociation of Telomerase RNP and the Chromosome End (Homo sapiens)
Telomerase Holoenzyme:Telomeric RNP End with Two Additional Single Stranded Telomere Repeats [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Telomeric G-strand chromosome end with two additional single strand repeats [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Elongation Of The Telomeric Chromosome End (Homo sapiens)
Telomerase RNP Bound and base-paired to the Telomeric Chromosome End [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Elongation of Extended Telomeric Chromosome End (Homo sapiens)
Telomerase Holoenzyme Base-paired to the Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Telomerase Holoenzyme:Telomeric RNP End with Two Additional Single Stranded Telomere Repeats [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
PP6-PPP6R3 dephosphorylates TERF2 (Homo sapiens)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Recruitment of Telomerase RNP to the Telomeric Chromosome End (Homo sapiens)
Telomerase RNP:G-strand telomeric chromosome end [nucleoplasm] (Homo sapiens)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Homo sapiens)
Telomerase Holoenzyme Base-paired to the Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Inhibition of DNA recombination at telomere (Homo sapiens)
ATRX:DAXX binds to subtelomeric chromosomal regions (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Telomere:Shelterin:Nucleosome:ATRX:DAXX [nucleoplasm] (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Histone H3.3 deposition at telomere (Homo sapiens)
Telomere:Shelterin:Nucleosome (H3F3A):ATRX:DAXX [nucleoplasm] (Homo sapiens)
Telomere:Shelterin:Nucleosome (H3F3A) [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Telomere:Shelterin:Nucleosome:ATRX:DAXX [nucleoplasm] (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
TERRA transcription (Homo sapiens)
Telomere:Shelterin:Nucleosome (H3F3A):ATRX:DAXX [nucleoplasm] (Homo sapiens)
Telomere:Shelterin:Nucleosome (H3F3A) [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Packaging Of Telomere Ends (Homo sapiens)
Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Homo sapiens)
Extended And Processed Telomere End [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex [nucleoplasm] (Homo sapiens)
Extended And Processed Telomere End [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex [nucleoplasm] (Homo sapiens)
Extended And Processed Telomere End [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic synapsis (Homo sapiens)
Telomeres cluster at the nuclear membrane (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Telomere Attachment Plate [nuclear envelope] (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)
Telomere shortening during replicative exhaustion (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Base-Excision Repair, AP Site Formation (Homo sapiens)
Depurination (Homo sapiens)
Cleavage of the damaged purine (Homo sapiens)
NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Homo sapiens)
NEIL3:AP-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
AP-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
NEIL3:Gh-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Gh-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
NEIL3 cleaves spiroiminodihydantoin from damaged telomeric DNA (Homo sapiens)
NEIL3:AP-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
AP-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
NEIL3:Sp-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Sp-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Recognition and association of DNA glycosylase with site containing an affected purine (Homo sapiens)
NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Homo sapiens)
Gh-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
NEIL3:Gh-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Gh-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
NEIL3 recognizes and binds to spiroiminodihydantoin in telomeric DNA (Homo sapiens)
NEIL3:Sp-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Sp-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Sp-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Depyrimidination (Homo sapiens)
Cleavage of the damaged pyrimidine (Homo sapiens)
NEIL3 cleaves thymine glycol from telomeric DNA (Homo sapiens)
NEIL3:AP-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
AP-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
NEIL3:Tg-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Tg-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Recognition and association of DNA glycosylase with site containing an affected pyrimidine (Homo sapiens)
NEIL3 recognizes and binds to thymine glycol in telomeric DNA (Homo sapiens)
NEIL3:Tg-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Tg-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Tg-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Reproduction (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic synapsis (Homo sapiens)
Telomeres cluster at the nuclear membrane (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
Telomere Attachment Plate [nuclear envelope] (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF2 homodimer [nucleoplasm] (Homo sapiens)
TERF2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15554 TERF2
Gene Names
TERF2, TRBF2, TRF2
Chain
chain:1-542
Reference Genes
COSMIC (genes):TERF2 Q155544
dbSNP Gene:7014 Q155544
ENSEMBL:ENSG00000132604 TERF2
Participates
as a component of
TERF2 homodimer [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-S365-TERF2 [nucleoplasm]
Inferred To
TERF2 [nucleoplasm]
(Bos taurus)
TERF2 [nucleoplasm]
(Canis familiaris)
TERF2 [nucleoplasm]
(Gallus gallus)
TERF2 [nucleoplasm]
(Sus scrofa)
Ghost homologue of TERF2 [nucleoplasm]
(Schizosaccharomyces pombe)
Ghost homologue of TERF2 [nucleoplasm]
(Xenopus tropicalis)
Terf2 [nucleoplasm]
(Mus musculus)
Terf2 [nucleoplasm]
(Rattus norvegicus)
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NUX5 POT1
1
POT1 [nucleoplasm]
(R-HSA-174890)
0.886
10
UniProt:P54132 BLM
2
BLM [nucleoplasm]
(R-HSA-174881)
4SUMO2,3-BLM [nucleoplasm]
(R-HSA-4568883)
0.691
8
UniProt:P16104 H2AFX
7
H2AFX [nucleoplasm]
(R-HSA-56151)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
H2AFX [extracellular region]
(R-HSA-977583)
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
0.681
4
UniProt:Q14191 WRN
2
WRN [nucleoplasm]
(R-HSA-67387)
monoSUMO1-K356,K496,K898-WRN [nucleoplasm]
(R-HSA-4568904)
0.655
8
UniProt:Q13416 ORC2
1
ORC2 [nucleoplasm]
(R-HSA-68405)
0.602
3
UniProt:Q8NEM0 MCPH1
1
MCPH1 [nucleoplasm]
(R-HSA-2429638)
0.582
5
UniProt:Q13315 ATM
5
ATM [cytosol]
(R-HSA-9665171)
ATM [peroxisomal matrix]
(R-HSA-9665169)
p-S1981,Ac-K3016-ATM [nucleoplasm]
(R-HSA-5693527)
ATM [nucleoplasm]
(R-HSA-69484)
Ac-K3016-ATM [nucleoplasm]
(R-HSA-5682043)
0.544
2
UniProt:Q13415 ORC1
5
ORC1 [nucleoplasm]
(R-HSA-68522)
ORC1 [cytosol]
(R-HSA-113840)
p-S,T-ORC1 [nucleoplasm]
(R-HSA-68943)
PolyUb,p-S,T-ORC1 [nucleoplasm]
(R-HSA-9032189)
PolyUb,p-S,T-ORC1 [cytosol]
(R-HSA-9032195)
0.544
2
UniProt:Q6NZI2 PTRF
2
PTRF [nucleoplasm]
(R-HSA-74981)
CAVIN1 [plasma membrane]
(R-HSA-9714278)
0.527
2
UniProt:P56559 ARL4C
1
ARL4C [plasma membrane]
(R-HSA-9618406)
0.527
2
UniProt:P06865 HEXA
3
HEXA(23-73) [lysosomal lumen]
(R-HSA-9842401)
HEXA(88-528) [lysosomal lumen]
(R-HSA-1605799)
HEXA Y427Ifs*5 [lysosomal lumen]
(R-HSA-3700918)
0.527
2
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.508
2
UniProt:Q13472 TOP3A
2
TOP3A [mitochondrial matrix]
(R-HSA-9914882)
TOP3A [nucleoplasm]
(R-HSA-912452)
0.463
4
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