Reactome | TOP3A [nucleoplasm]

TOP3A [nucleoplasm]

Stable Identifier

R-HSA-912452

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA topoisomerase 3-alpha, TOP3A_HUMAN

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G2/M Checkpoints (Homo sapiens)
    - G2/M DNA damage checkpoint (Homo sapiens)
      - ATR phosphorylates TP53 (Homo sapiens)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
- Meiosis (Homo sapiens)
  - Meiotic recombination (Homo sapiens)
    - Formation of meiotic holliday junction (Homo sapiens)
      - Meiotic Holliday Junction [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
      - TOP3A [nucleoplasm] (Homo sapiens)
    - Resolution of meiotic holliday junction (Homo sapiens)
      - Meiotic Holliday Junction [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
      - TOP3A [nucleoplasm] (Homo sapiens)

DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - HDR through Homologous Recombination (HRR) (Homo sapiens)
        
        D-loop extension by DNA polymerases (Homo sapiens)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        Homologous DNA Pairing and Strand Exchange (Homo sapiens)
        
        CX3 complex binds D-loop structures (Homo sapiens)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        D-loop formation mediated by PALB2, BRCA2 and RAD51 (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        Presynaptic phase of homologous DNA pairing and strand exchange (Homo sapiens)
        
        BCDX2 complex stabilizes RAD51 filament (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        RAD51 binds BRCA2 at resected DNA DSBs (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        Resolution of D-Loop Structures (Homo sapiens)
        
        Resolution of D-loop Structures through Holliday Junction Intermediates (Homo sapiens)
        
        BLM mediates dissolution of double Holliday junction (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2:SPIDR [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        Ligation of DNA and formation of Holliday structures following repair synthesis (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        MUS81:EME1,EME2 cleaves D-loop (Homo sapiens)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 (Homo sapiens)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        SPIDR binds BLM:TOP3A:RMI1:RMI2 (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2:SPIDR [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) (Homo sapiens)
        
        D-loop dissociation and strand annealing (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
      - HDR through Single Strand Annealing (SSA) (Homo sapiens)
        
        Association of RAD51 with RAD52:DNA double-strand break ends (Homo sapiens)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        Association of RAD52 with the RPA complex at resected DNA DSBs (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        ERCC1:XPF cleaves flaps generated by SSA (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        RAD52 promotes single strand annealing at resected DNA DSBs (Homo sapiens)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
      - Processing of DNA double-strand break ends (Homo sapiens)
        
        ATR activation at DNA DSBs (Homo sapiens)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        ATR phosphorylates RPA2 (Homo sapiens)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        Activation of CHEK1 at resected DNA DSBs (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        Association of RPA complexes with ssDNA at resected DNA DSBs (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        Binding of ATR:ATRIP to RPA at resected DNA DSBs (Homo sapiens)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        CHEK1 is recruited to resected DNA DSBs (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Homo sapiens)
        
        3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        Long-range resection of DNA DSBs by EXO1 or DNA2 (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
        
        3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)

Disease (Homo sapiens)

- Diseases of DNA repair (Homo sapiens)
  - Diseases of DNA Double-Strand Break Repair (Homo sapiens)
    - Defective homologous recombination repair (HRR) due to BRCA1 loss of function (Homo sapiens)
      - Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding (Homo sapiens)
        
        Defective 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        Defective 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
    - Defective homologous recombination repair (HRR) due to BRCA2 loss of function (Homo sapiens)
      - Impaired BRCA2 binding to PALB2 (Homo sapiens)
        
        Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:BRCA2 mutants (PALB2 binding):SEM1:BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:BRCA2 mutants (PALB2 binding):SEM1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
      - Impaired BRCA2 binding to RAD51 (Homo sapiens)
        
        BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51 (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
    - Defective homologous recombination repair (HRR) due to PALB2 loss of function (Homo sapiens)
      - Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function (Homo sapiens)
        
        Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)
      - Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function (Homo sapiens)
        
        Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        ATR phosphorylates TP53 (Homo sapiens)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        TOP3A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13472 TOP3A

Gene Names

TOP3A, TOP3

Chain

chain:1-1001

Reference Genes

BioGPS Gene:7156 TOP3A

COSMIC (genes):TOP3A TOP3A

CTD Gene:7156 TOP3A

dbSNP Gene:7156 TOP3A

ENSEMBL:ENSG00000177302 TOP3A

ENSEMBL:ENSG00000177302.15 TOP3A

ENSEMBL:ENSG00000284238.2 TOP3A

HGNC:11992 TOP3A

KEGG Gene (Homo sapiens):7156 TOP3A

Monarch:7156 TOP3A

NCBI Gene:7156 TOP3A

OMIM:601243 TOP3A

UCSC:Q13472 TOP3A

Reference Transcript

Other Identifiers

0006040427

1028_at

11728247_a_at

11747776_a_at

16842070

204946_PM_s_at

204946_s_at

214299_PM_at

214299_at

214300_PM_s_at

214300_s_at

3748254

3748256

3748258

3748260

3748261

3748263

3748264

3748265

3748266

3748267

3748268

3748269

3748270

3748271

3748272

3748277

3748278

3748279

3748280

3748282

3748284

3748285

3748286

3748288

3748289

3748290

3748291

3748292

3748293

3748294

3748295

3748298

3748301

3748304

3748306

3748314

3748315

3748316

41004_at

7156

77063_at

8013222

GE59166

GO:0000724

GO:0003677

GO:0003697

GO:0003916

GO:0003917

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005739

GO:0005759

GO:0006265

GO:0006281

GO:0006310

GO:0007005

GO:0007059

GO:0008270

GO:0016605

GO:0016853

GO:0022414

GO:0031422

GO:0032042

GO:0032991

GO:0043226

GO:0043229

GO:0046872

GO:0051304

GO:0051321

GO:0071139

GO:0140097

HMNXSV003028500

Hs.91175.1.S1_3p_at

ILMN_1700487

ILMN_1827615

ILMN_2072973

PH_hs_0025390

PH_hs_0033363

TC17001200.hg

U43431_at

g10835217_3p_s_at

Participates

as an input of

Formation of meiotic holliday junction (Homo sapiens)

as an output of

Resolution of meiotic holliday junction (Homo sapiens)

as a component of

Inferred To

Top3a [nucleoplasm] (Rattus norvegicus)

top3a [nucleoplasm] (Xenopus tropicalis)

TOP3A [nucleoplasm] (Bos taurus)

TOP3A [nucleoplasm] (Caenorhabditis elegans)

TOP3A [nucleoplasm] (Canis familiaris)

TOP3A [nucleoplasm] (Danio rerio)

TOP3A [nucleoplasm] (Gallus gallus)

TOP3A [nucleoplasm] (Mus musculus)

TOP3A [nucleoplasm] (Sus scrofa)

top3 [nucleoplasm] (Dictyostelium discoideum)

Cross References

RefSeq

NP_004609.1, NP_001307688.1

OpenTargets

ENSG00000177302

HPA

ENSG00000177302-TOP3A

GeneCards

Q13472

Ensembl

ENST00000321105, ENST00000639065, ENSP00000492229, ENSP00000491689, ENSP00000462790, ENSG00000284238, ENST00000638894, ENSP00000442336, ENSP00000491260, ENST00000640743, ENST00000542570, ENSG00000177302, ENST00000580095, ENSP00000321636

PRO

Q13472

Pharos - Targets

Q13472

Orphanet

27334

PDB

4CHT, 4CGY

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H9A7 RMI1	1	RMI1 [nucleoplasm] (R-HSA-5685949)	0.912	10
UniProt:P54132 BLM	2	4SUMO2,3-BLM [nucleoplasm] (R-HSA-4568883) BLM [nucleoplasm] (R-HSA-174881)	0.853	9
UniProt:Q96E14-1 RMI2			0.527	2
UniProt:Q15554 TERF2	2	TERF2 [nucleoplasm] (R-HSA-174895) p-S365-TERF2 [nucleoplasm] (R-HSA-9686530)	0.463	4
UniProt:Q5UIP0 RIF1	1	RIF1 [nucleoplasm] (R-HSA-480742)	0.462	3
UniProt:Q14159 SPIDR	1	SPIDR [nucleoplasm] (R-HSA-5686408)	0.462	2

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