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About
What is Reactome ?
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TOP3A [nucleoplasm]
Stable Identifier
R-HSA-912452
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
DNA topoisomerase 3-alpha, TOP3A_HUMAN
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
G2/M DNA damage checkpoint (Homo sapiens)
ATR phosphorylates TP53 (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic recombination (Homo sapiens)
Formation of meiotic holliday junction (Homo sapiens)
Meiotic Holliday Junction [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Resolution of meiotic holliday junction (Homo sapiens)
Meiotic Holliday Junction [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
HDR through Homologous Recombination (HRR) (Homo sapiens)
D-loop extension by DNA polymerases (Homo sapiens)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Homologous DNA Pairing and Strand Exchange (Homo sapiens)
CX3 complex binds D-loop structures (Homo sapiens)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
D-loop formation mediated by PALB2, BRCA2 and RAD51 (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Presynaptic phase of homologous DNA pairing and strand exchange (Homo sapiens)
BCDX2 complex stabilizes RAD51 filament (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
RAD51 binds BRCA2 at resected DNA DSBs (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Resolution of D-Loop Structures (Homo sapiens)
Resolution of D-loop Structures through Holliday Junction Intermediates (Homo sapiens)
BLM mediates dissolution of double Holliday junction (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2:SPIDR [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)
Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Ligation of DNA and formation of Holliday structures following repair synthesis (Homo sapiens)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
MUS81:EME1,EME2 cleaves D-loop (Homo sapiens)
Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 (Homo sapiens)
Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)
Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
SPIDR binds BLM:TOP3A:RMI1:RMI2 (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2:SPIDR [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) (Homo sapiens)
D-loop dissociation and strand annealing (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
HDR through Single Strand Annealing (SSA) (Homo sapiens)
Association of RAD51 with RAD52:DNA double-strand break ends (Homo sapiens)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Association of RAD52 with the RPA complex at resected DNA DSBs (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
ERCC1:XPF cleaves flaps generated by SSA (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
RAD52 promotes single strand annealing at resected DNA DSBs (Homo sapiens)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Processing of DNA double-strand break ends (Homo sapiens)
ATR activation at DNA DSBs (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
ATR phosphorylates RPA2 (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Activation of CHEK1 at resected DNA DSBs (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Association of RPA complexes with ssDNA at resected DNA DSBs (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Binding of ATR:ATRIP to RPA at resected DNA DSBs (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
CHEK1 is recruited to resected DNA DSBs (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Homo sapiens)
3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Long-range resection of DNA DSBs by EXO1 or DNA2 (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of DNA repair (Homo sapiens)
Diseases of DNA Double-Strand Break Repair (Homo sapiens)
Defective homologous recombination repair (HRR) due to BRCA1 loss of function (Homo sapiens)
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding (Homo sapiens)
Defective 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:BCDX2 complex [nucleoplasm] (Homo sapiens)
Defective 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Defective homologous recombination repair (HRR) due to BRCA2 loss of function (Homo sapiens)
Impaired BRCA2 binding to PALB2 (Homo sapiens)
Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:BRCA2 mutants (PALB2 binding):SEM1:BCDX2 complex [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:BRCA2 mutants (PALB2 binding):SEM1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Impaired BRCA2 binding to RAD51 (Homo sapiens)
BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51 (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Defective homologous recombination repair (HRR) due to PALB2 loss of function (Homo sapiens)
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function (Homo sapiens)
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function (Homo sapiens)
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
ATR phosphorylates TP53 (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Reproduction (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic recombination (Homo sapiens)
Formation of meiotic holliday junction (Homo sapiens)
Meiotic Holliday Junction [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Resolution of meiotic holliday junction (Homo sapiens)
Meiotic Holliday Junction [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13472 TOP3A
Gene Names
TOP3A, TOP3
Chain
chain:1-1001
Reference Genes
BioGPS Gene:7156 TOP3A
COSMIC (genes):TOP3A TOP3A
CTD Gene:7156 TOP3A
dbSNP Gene:7156 TOP3A
ENSEMBL:ENSG00000177302 TOP3A
ENSEMBL:ENSG00000177302.15 TOP3A
ENSEMBL:ENSG00000284238.2 TOP3A
HGNC:11992 TOP3A
KEGG Gene (Homo sapiens):7156 TOP3A
Monarch:7156 TOP3A
NCBI Gene:7156 TOP3A
OMIM:601243 TOP3A
UCSC:Q13472 TOP3A
Reference Transcript
RefSeq:NM_004618.4 TOP3A
RefSeq:NM_001320759.1 TOP3A
Other Identifiers
0006040427
1028_at
11728247_a_at
11747776_a_at
16842070
204946_PM_s_at
204946_s_at
214299_PM_at
214299_at
214300_PM_s_at
214300_s_at
3748254
3748256
3748258
3748260
3748261
3748263
3748264
3748265
3748266
3748267
3748268
3748269
3748270
3748271
3748272
3748277
3748278
3748279
3748280
3748282
3748284
3748285
3748286
3748288
3748289
3748290
3748291
3748292
3748293
3748294
3748295
3748298
3748301
3748304
3748306
3748314
3748315
3748316
41004_at
7156
77063_at
8013222
GE59166
GO:0000724
GO:0003677
GO:0003697
GO:0003916
GO:0003917
GO:0005515
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005739
GO:0005759
GO:0006265
GO:0006281
GO:0006310
GO:0007005
GO:0007059
GO:0008270
GO:0016605
GO:0016853
GO:0022414
GO:0031422
GO:0032042
GO:0032991
GO:0043226
GO:0043229
GO:0046872
GO:0051304
GO:0051321
GO:0071139
GO:0140097
HMNXSV003028500
Hs.91175.1.S1_3p_at
ILMN_1700487
ILMN_1827615
ILMN_2072973
PH_hs_0025390
PH_hs_0033363
TC17001200.hg
U43431_at
g10835217_3p_s_at
Participates
as an input of
Formation of meiotic holliday junction (Homo sapiens)
as an output of
Resolution of meiotic holliday junction (Homo sapiens)
as a component of
Meiotic Holliday Junction [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
Inferred To
Top3a [nucleoplasm]
(Rattus norvegicus)
top3a [nucleoplasm]
(Xenopus tropicalis)
TOP3A [nucleoplasm]
(Bos taurus)
TOP3A [nucleoplasm]
(Caenorhabditis elegans)
TOP3A [nucleoplasm]
(Canis familiaris)
TOP3A [nucleoplasm]
(Danio rerio)
TOP3A [nucleoplasm]
(Gallus gallus)
TOP3A [nucleoplasm]
(Mus musculus)
TOP3A [nucleoplasm]
(Sus scrofa)
top3 [nucleoplasm]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_004609.1
,
NP_001307688.1
OpenTargets
ENSG00000177302
HPA
ENSG00000177302-TOP3A
GeneCards
Q13472
Ensembl
ENST00000321105
,
ENST00000639065
,
ENSP00000492229
,
ENSP00000491689
,
ENSP00000462790
,
ENSG00000284238
,
ENST00000638894
,
ENSP00000442336
,
ENSP00000491260
,
ENST00000640743
,
ENST00000542570
,
ENSG00000177302
,
ENST00000580095
,
ENSP00000321636
PRO
Q13472
Pharos - Targets
Q13472
Orphanet
27334
PDB
4CHT
,
4CGY
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H9A7 RMI1
1
RMI1 [nucleoplasm]
(R-HSA-5685949)
0.912
10
UniProt:P54132 BLM
2
4SUMO2,3-BLM [nucleoplasm]
(R-HSA-4568883)
BLM [nucleoplasm]
(R-HSA-174881)
0.853
9
UniProt:Q96E14-1 RMI2
0.527
2
UniProt:Q15554 TERF2
2
TERF2 [nucleoplasm]
(R-HSA-174895)
p-S365-TERF2 [nucleoplasm]
(R-HSA-9686530)
0.463
4
UniProt:Q5UIP0 RIF1
1
RIF1 [nucleoplasm]
(R-HSA-480742)
0.462
3
UniProt:Q14159 SPIDR
1
SPIDR [nucleoplasm]
(R-HSA-5686408)
0.462
2
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