Reactome | ORC1 [nucleoplasm]

ORC1 [nucleoplasm]

Stable Identifier

R-HSA-68522

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Orc1, Origin recognition complex subunit 1, Replication control protein 1

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Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G2/M Checkpoints (Homo sapiens)
    - Activation of ATR in response to replication stress (Homo sapiens)
      - Activation of claspin (Homo sapiens)
        
        Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
      - Loading of claspin onto DNA during replication origin firing (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G1/S Transition (Homo sapiens)
      - Activation of the pre-replicative complex (Homo sapiens)
        
        CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
        
        Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
        
        Cdt1 is displaced from the pre-replicative complex. (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
        
        MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
        
        DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
        
        DNA polymerase alpha:primase binds at the origin (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon binds at the origin (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
        
        Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Homo sapiens)
        
        MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
        
        pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
      - E2F mediated regulation of DNA replication (Homo sapiens)
        
        E2F-enabled inhibition of pre-replication complex formation (Homo sapiens)
        
        Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation (Homo sapiens)
        
        Cyclin B:CDK1:ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
      - G1/S-Specific Transcription (Homo sapiens)
        
        ORC1 gene expression is stimulated by E2F1 (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Synthesis of DNA (Homo sapiens)
      - Switching of origins to a post-replicative state (Homo sapiens)
        
        Orc1 removal from chromatin (Homo sapiens)
        
        Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)
        
        pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)

DNA Replication (Homo sapiens)

- DNA Replication Pre-Initiation (Homo sapiens)
  - Activation of the pre-replicative complex (Homo sapiens)
    - CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
      - MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
    - Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
    - Cdt1 is displaced from the pre-replicative complex. (Homo sapiens)
      - MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
      - MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
    - DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
    - DNA polymerase alpha:primase binds at the origin (Homo sapiens)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
    - DNA polymerase epsilon binds at the origin (Homo sapiens)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
    - Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Homo sapiens)
      - MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
      - pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
  - Assembly of the pre-replicative complex (Homo sapiens)
    - ATP-dependent release of CDT1 from the OCCM complex (Homo sapiens)
      - ORC(1-6):CDC6:origin of replication:CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
        
        ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5) [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
      - ORC(1-6):CDC6:origin of replication:MCM2-7 [nucleoplasm] (Homo sapiens)
        
        ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5) [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
    - Assembly of the ORC complex at the origin of replication (Homo sapiens)
      - Formation of ORC(1-5) complex (Homo sapiens)
        
        ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5) [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
        
        ORC1:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
      - Formation of ORC(1-6) complex (Homo sapiens)
        
        ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5) [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
        
        ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5) [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
      - ORC1 binds to DNA at origin of replication sites (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
        
        ORC1:H4K20Me2-nucleosome [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
        
        ORC1:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
      - ORC1 binds to H4K20me2 (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
        
        ORC1:H4K20Me2-nucleosome [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
      - ORC1 translocates to the nucleus (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
    - CDC6 association with the ORC:origin complex (Homo sapiens)
      - CDC6 association with ORC(1-6) at replication origins (Homo sapiens)
        
        ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5) [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
        
        ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5) [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
    - CDT1-mediated formation of MCM2-7 double hexamer at the replication origin (Homo sapiens)
      - ORC(1-6):CDC6:origin of replication:MCM2-7 [nucleoplasm] (Homo sapiens)
        
        ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5) [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
      - ORC(1-6):CDC6:origin or replication:MCM2-7 double hexamer [nucleoplasm] (Homo sapiens)
        
        ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5) [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
    - CDT1-mediated loading of MCM2-7 to replication origins (Homo sapiens)
      - ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5) [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
      - ORC(1-6):CDC6:origin of replication:CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
        
        ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5) [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)
- Synthesis of DNA (Homo sapiens)
  - Switching of origins to a post-replicative state (Homo sapiens)
    - Orc1 removal from chromatin (Homo sapiens)
      - Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)
        
        pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
        
        ORC:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13415 ORC1

Gene Names

ORC1, ORC1L, PARC1

Chain

chain:1-861

Reference Genes

BioGPS Gene:4998 ORC1

COSMIC (genes):ORC1 ORC1

CTD Gene:4998 ORC1

dbSNP Gene:4998 ORC1

ENSEMBL:ENSG00000085840.13 ORC1

HGNC:8487 ORC1

KEGG Gene (Homo sapiens):4998 ORC1

Monarch:4998 ORC1

NCBI Gene:4998 ORC1

OMIM:601902 ORC1

UCSC:Q13415 ORC1

Reference Transcript

Other Identifiers

0005690452

11727839_x_at

16687188

205085_PM_at

205085_at

2412800

2412801

2412802

2412803

2412804

2412805

2412807

2412809

2412810

2412811

2412812

2412813

2412814

2412815

2412818

2412819

2412820

2412822

2412823

2412824

2412825

2412826

2412827

2412829

2412830

2412831

2412833

38564_at

4998

7916167

A_23_P45799

GE59132

GO:0000166

GO:0000228

GO:0000278

GO:0000781

GO:0000808

GO:0003677

GO:0003682

GO:0003688

GO:0005515

GO:0005524

GO:0005622

GO:0005634

GO:0005654

GO:0005664

GO:0005694

GO:0005737

GO:0005829

GO:0006260

GO:0006270

GO:0016787

GO:0016887

GO:0023052

GO:0032991

GO:0033314

GO:0043226

GO:0046872

GO:0140657

HMNXSV003053435

ILMN_1727459

ILMN_1761836

PH_hs_0001609

TC01002658.hg

U40152_s_at

g4758849_3p_at

g4758849_3p_x_at

Participates

as an output of

as an input of

as a component of

Other forms of this molecule

ORC1 [cytosol]

p-S,T-ORC1 [nucleoplasm]

PolyUb,p-S,T-ORC1 [nucleoplasm]

PolyUb,p-S,T-ORC1 [cytosol]

Inferred To

ORC1 [nucleoplasm] (Bos taurus)

ORC1 [nucleoplasm] (Canis familiaris)

ORC1 [nucleoplasm] (Danio rerio)

ORC1 [nucleoplasm] (Dictyostelium discoideum)

ORC1 [nucleoplasm] (Drosophila melanogaster)

ORC1 [nucleoplasm] (Gallus gallus)

ORC1 [nucleoplasm] (Mus musculus)

ORC1 [nucleoplasm] (Plasmodium falciparum)

ORC1 [nucleoplasm] (Rattus norvegicus)

ORC1 [nucleoplasm] (Saccharomyces cerevisiae)

ORC1 [nucleoplasm] (Schizosaccharomyces pombe)

ORC1 [nucleoplasm] (Sus scrofa)

orc-1 [nucleoplasm] (Caenorhabditis elegans)

orc1 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001177748.1, NP_004144.2, NP_001177747.1

OpenTargets

ENSG00000085840

GeneCards

Q13415

HPA

ENSG00000085840-ORC1

Ensembl

ENST00000371566, ENSG00000085840, ENSP00000360623, ENST00000371568, ENSP00000360621

PRO

Q13415

Pharos - Targets

Q13415

Orphanet

19843

PDB

7CTF, 5UJ7, 7JPO, 7JPR, 6P3W, 7JPP, 7JPS, 7CTG, 5UJM

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13416 ORC2	1	ORC2 [nucleoplasm] (R-HSA-68405)	0.888	14
UniProt:O43913 ORC5	1	ORC5 [nucleoplasm] (R-HSA-68516)	0.868	11
UniProt:Q9UBD5 ORC3	1	ORC3 [nucleoplasm] (R-HSA-68513)	0.824	16
UniProt:O43929 ORC4	1	ORC4 [nucleoplasm] (R-HSA-68519)	0.737	8
UniProt:P20248 CCNA2	3	PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099) CCNA2 [cytosol] (R-HSA-157444) CCNA2 [nucleoplasm] (R-HSA-68905)	0.643	3
IntAct:EBI-15973242 H4(1129)			0.618	3
UniProt:A6NEM1 GG6L9			0.556	3
UniProt:P03211 EBNA1			0.544	2
UniProt:Q15554 TERF2	2	TERF2 [nucleoplasm] (R-HSA-174895) p-S365-TERF2 [nucleoplasm] (R-HSA-9686530)	0.544	2
UniProt:Q13309 SKP2	3	SKP2 [nucleoplasm] (R-HSA-975554) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [cytosol] (R-HSA-975495)	0.524	2

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