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ORC1 [nucleoplasm]
Stable Identifier
R-HSA-68522
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Orc1, Origin recognition complex subunit 1, Replication control protein 1
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
Activation of ATR in response to replication stress (Homo sapiens)
Activation of claspin (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
Loading of claspin onto DNA during replication origin firing (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
Cdt1 is displaced from the pre-replicative complex (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
E2F mediated regulation of DNA replication (Homo sapiens)
E2F-enabled inhibition of pre-replication complex formation (Homo sapiens)
Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation (Homo sapiens)
Cyclin B:CDK1:ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
G1/S-Specific Transcription (Homo sapiens)
ORC1 gene expression is stimulated by E2F1 (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
Cdt1 is displaced from the pre-replicative complex (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
ATP-dependent release of CDT1 from the OCCM complex (Homo sapiens)
ORC(1-6):CDC6:origin of replication:CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication:MCM2-7 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
Assembly of the ORC complex at the origin of replication (Homo sapiens)
Formation of ORC(1-5) complex (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
ORC1:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
Formation of ORC(1-6) complex (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
ORC1 binds to DNA at origin of replication sites (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
ORC1:H4K20Me2-nucleosome [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
ORC1:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
ORC1 binds to H4K20me2 (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
ORC1:H4K20Me2-nucleosome [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
ORC1 translocates to the nucleus (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
CDC6 association with the ORC:origin complex (Homo sapiens)
CDC6 association with ORC(1-6) at replication origins (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
CDT1-mediated formation of MCM2-7 double hexamer at the replication origin (Homo sapiens)
ORC(1-6):CDC6:origin of replication:MCM2-7 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin or replication:MCM2-7 double hexamer [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
CDT1-mediated loading of MCM2-7 to replication origins (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication:CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13415 ORC1
Gene Names
ORC1, ORC1L, PARC1
Chain
chain:1-861
Reference Genes
BioGPS Gene:4998 ORC1
COSMIC (genes):ORC1 SLC25A15
CTD Gene:4998 ORC1
dbSNP Gene:4998 Q96F82
ENSEMBL:ENSG00000085840 ORC1
HGNC:8487 ORC1
KEGG:hsa:4998 ORC1
Monarch:4998 ORC1
NCBI Gene:4998 ORC1
OMIM:601902 ORC1
UCSC:Q13415 ORC1
Reference Transcript
RefSeq:NM_004153.3 ORC1
RefSeq:NM_001190818.1 ORC1
RefSeq:NM_001190819.1 ORC1
Other Identifiers
11727839_x_at
16687188
205085_PM_at
205085_at
2412800
2412801
2412802
2412803
2412804
2412805
2412807
2412809
2412810
2412811
2412812
2412813
2412814
2412815
2412818
2412819
2412820
2412822
2412823
2412824
2412825
2412826
2412827
2412829
2412830
2412831
2412833
38564_at
4998
7916167
A_23_P45799
GE59132
GO:0000781
GO:0000808
GO:0003677
GO:0003682
GO:0003824
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005664
GO:0005829
GO:0006260
GO:0006270
GO:0016787
GO:0016887
GO:0033314
GO:0043226
GO:0046872
HMNXSV003053435
ILMN_1727459
PH_hs_0001609
TC01002658.hg
U40152_s_at
g4758849_3p_at
g4758849_3p_x_at
Participates
as an output of
ORC1 gene expression is stimulated by E2F1 (Homo sapiens)
ORC1 translocates to the nucleus (Homo sapiens)
as an input of
ORC1 binds to H4K20me2 (Homo sapiens)
ORC1 binds to DNA at origin of replication sites (Homo sapiens)
as a component of
ORC1:H4K20Me2-nucleosome [nucleoplasm] (Homo sapiens)
ORC1:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Other forms of this molecule
ORC1 [cytosol]
p-S,T-ORC1 [nucleoplasm]
PolyUb,p-S,T-ORC1 [nucleoplasm]
PolyUb,p-S,T-ORC1 [cytosol]
Inferred To
ORC1 [nucleoplasm]
(Bos taurus)
ORC1 [nucleoplasm]
(Canis familiaris)
ORC1 [nucleoplasm]
(Dictyostelium discoideum)
ORC1 [nucleoplasm]
(Drosophila melanogaster)
ORC1 [nucleoplasm]
(Gallus gallus)
ORC1 [nucleoplasm]
(Mus musculus)
ORC1 [nucleoplasm]
(Plasmodium falciparum)
ORC1 [nucleoplasm]
(Rattus norvegicus)
ORC1 [nucleoplasm]
(Saccharomyces cerevisiae)
ORC1 [nucleoplasm]
(Schizosaccharomyces pombe)
ORC1 [nucleoplasm]
(Sus scrofa)
orc-1 [nucleoplasm]
(Caenorhabditis elegans)
orc1 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001177748.1
,
NP_001177747.1
,
NP_004144.2
OpenTargets
ENSG00000085840
ENSEMBL
ENSG00000085840
,
ENSP00000360621
,
ENST00000371566
,
ENSP00000360623
,
ENST00000371568
HPA
ENSG00000085840-ORC1
GeneCards
ORC1
PRO
Q13415
Pharos - Targets
Q13415
Orphanet
ORC1
GlyGen
Q13415
PDB
6P3W
,
5UJM
,
5UJ7
,
7JPS
,
8S0E
,
7JPP
,
8S0C
,
7JPO
,
8S0F
,
8S0D
,
7CTG
,
7CTF
,
7JPR
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13416 ORC2
1
ORC2 [nucleoplasm]
(R-HSA-68405)
0.888
14
UniProt:O43913 ORC5
1
ORC5 [nucleoplasm]
(R-HSA-68516)
0.868
11
UniProt:Q9UBD5 ORC3
1
ORC3 [nucleoplasm]
(R-HSA-68513)
0.824
16
UniProt:O43929 ORC4
1
ORC4 [nucleoplasm]
(R-HSA-68519)
0.737
8
UniProt:P20248 CCNA2
5
p-S154-CCNA2 [nucleoplasm]
(R-HSA-9929512)
p-S154-CCNA2 [cytosol]
(R-HSA-9929551)
CCNA2 [nucleoplasm]
(R-HSA-68905)
CCNA2 [cytosol]
(R-HSA-157444)
PolyUb-CCNA2 [nucleoplasm]
(R-HSA-6783099)
0.725
5
IntAct:EBI-15973242 H4(1129)
0.618
3
UniProt:A6NEM1 GG6L9
0.556
3
UniProt:Q15554 TERF2
2
TERF2 [nucleoplasm]
(R-HSA-174895)
p-S365-TERF2 [nucleoplasm]
(R-HSA-9686530)
0.544
2
UniProt:P03211 EBNA1
0.544
2
UniProt:Q13309 SKP2
3
SKP2 [nucleoplasm]
(R-HSA-975554)
PolyUb-SKP2 [nucleoplasm]
(R-HSA-9687073)
SKP2 [cytosol]
(R-HSA-975495)
0.524
2
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![ORC1 [nucleoplasm] icon](/icon/R-ICO-013133.svg){kind=icon}
