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TOP3A [mitochondrial matrix]
Stable Identifier
R-HSA-9914882
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
DNA topoisomerase 3-alpha ecNumber evidence="5 10 14"5.6.2.1, TOP3A_HUMAN
Locations in the PathwayBrowser
Expand all
DNA Replication (Homo sapiens)
Strand-asynchronous mitochondrial DNA replication (Homo sapiens)
TOP3A (Topoisomerase 3a) decatenates mitochondrial DNA (Homo sapiens)
TOP3A:Mg2+ [mitochondrial matrix] (Homo sapiens)
TOP3A [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13472 TOP3A
Gene Names
TOP3A, TOP3
Chain
chain:1-1001
Reference Genes
BioGPS Gene:7156 TOP3A
COSMIC - genes:TOP3A TOP3A
CTD Gene:7156 TOP3A
dbSNP Gene:7156 TOP3A
ENSEMBL:ENSG00000177302 TOP3A
HGNC:11992 TOP3A
KEGG:hsa:7156 TOP3A
Monarch:7156 TOP3A
NCBI Gene:7156 TOP3A
OMIM:601243 TOP3A
UCSC:Q13472 TOP3A
Reference Transcript
RefSeq:NM_001320759.2 TOP3A
RefSeq:NM_004618.5 TOP3A
Other Identifiers
1028_at
11728247_a_at
11747776_a_at
16842070
204946_PM_s_at
204946_s_at
214299_PM_at
214299_at
214300_PM_s_at
214300_s_at
3748254
3748256
3748258
3748260
3748261
3748263
3748264
3748265
3748266
3748267
3748268
3748269
3748270
3748271
3748272
3748277
3748278
3748279
3748280
3748281
3748282
3748284
3748285
3748286
3748288
3748289
3748290
3748291
3748292
3748293
3748294
3748295
3748296
3748298
3748300
3748301
3748302
3748303
3748304
3748305
3748306
3748314
3748315
3748316
41004_at
7156
77063_at
8013222
GE59166
GO:0000724
GO:0003676
GO:0003677
GO:0003697
GO:0003824
GO:0003916
GO:0003917
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005739
GO:0005759
GO:0006265
GO:0006281
GO:0006310
GO:0008270
GO:0016605
GO:0016853
GO:0022414
GO:0031422
GO:0032042
GO:0046872
GO:0051304
GO:0051321
GO:0071139
GO:0140097
HMNXSV003028500
Hs.91175.1.S1_3p_at
ILMN_1700487
ILMN_2072973
PH_hs_0025390
PH_hs_0033363
TC17001200.hg
U43431_at
g10835217_3p_s_at
Participates
as a component of
TOP3A:Mg2+ [mitochondrial matrix] (Homo sapiens)
Other forms of this molecule
TOP3A [nucleoplasm]
Cross References
RefSeq
NP_004609.1
,
NP_001307688.1
ENSEMBL
ENSP00000491260
,
ENSG00000177302
,
ENSP00000321636
,
ENSP00000491689
,
ENST00000640743
,
ENST00000580095
,
ENSG00000284238
,
ENSP00000462790
,
ENST00000321105
,
ENST00000639065
OpenTargets
ENSG00000177302
IntEnz
5.6.2.1
GeneCards
TOP3A
HPA
ENSG00000177302-TOP3A
PRO
Q13472
Pharos - Targets
Q13472
Orphanet
TOP3A
PDB
4CHT
,
4CGY
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H9A7 RMI1
1
RMI1 [nucleoplasm]
(R-HSA-5685949)
0.94
11
UniProt:P54132 BLM
2
BLM [nucleoplasm]
(R-HSA-174881)
4SUMO2,3-BLM [nucleoplasm]
(R-HSA-4568883)
0.888
10
UniProt:P12273 PIP
1
PIP [extracellular region]
(R-HSA-5252061)
0.527
2
UniProt:P23025 XPA
1
XPA [nucleoplasm]
(R-HSA-67437)
0.527
2
UniProt:Q96E14-1 RMI2
0.527
2
UniProt:Q15554 TERF2
2
TERF2 [nucleoplasm]
(R-HSA-174895)
p-S365-TERF2 [nucleoplasm]
(R-HSA-9686530)
0.463
4
UniProt:Q5UIP0 RIF1
1
RIF1 [nucleoplasm]
(R-HSA-480742)
0.462
3
UniProt:Q14159 SPIDR
1
SPIDR [nucleoplasm]
(R-HSA-5686408)
0.462
2
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