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ORC2 [nucleoplasm]
Stable Identifier
R-HSA-68405
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Orc2, Origin recognition complex subunit 2
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
Activation of ATR in response to replication stress (Homo sapiens)
Activation of claspin (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
Loading of claspin onto DNA during replication origin firing (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
Cdt1 is displaced from the pre-replicative complex. (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
E2F mediated regulation of DNA replication (Homo sapiens)
E2F-enabled inhibition of pre-replication complex formation (Homo sapiens)
Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation (Homo sapiens)
Cyclin B:CDK1:ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
Cdt1 is displaced from the pre-replicative complex. (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
ATP-dependent release of CDT1 from the OCCM complex (Homo sapiens)
ORC(1-6):CDC6:origin of replication:CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication:MCM2-7 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
Assembly of the ORC complex at the origin of replication (Homo sapiens)
Formation of ORC(1-5) complex (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
Formation of ORC(1-6) complex (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
Formation of ORC(2-5) complex (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
ORC2 binds ORC3 (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
ORC5 binds ORC2:ORC3 (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
CDC6 association with the ORC:origin complex (Homo sapiens)
CDC6 association with ORC(1-6) at replication origins (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
CDT1-mediated formation of MCM2-7 double hexamer at the replication origin (Homo sapiens)
ORC(1-6):CDC6:origin of replication:MCM2-7 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin or replication:MCM2-7 double hexamer [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
CDT1-mediated loading of MCM2-7 to replication origins (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication:CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13416 ORC2
Gene Names
ORC2, ORC2L
Chain
chain:1-577
Reference Genes
BioGPS Gene:4999 ORC2
COSMIC (genes):ORC2 ORC2
CTD Gene:4999 ORC2
dbSNP Gene:4999 ORC2
ENSEMBL:ENSG00000115942 ORC2
ENSEMBL_homo_sapiens_GENE:ENSG00000115942.9 ORC2
HGNC:8488 ORC2
KEGG Gene (Homo sapiens):4999 ORC2
Monarch:4999 ORC2
NCBI Gene:4999 ORC2
OMIM:601182 ORC2
UCSC:Q13416 ORC2
Reference Transcript
RefSeq:XM_006712555.3 ORC2
RefSeq:NM_006190.4 ORC2
Other Identifiers
11729210_at
11729211_a_at
11746739_a_at
16907173
204853_PM_at
204853_at
235423_PM_at
235423_at
2594566
2594567
2594570
2594571
2594572
2594573
2594574
2594575
2594576
2594578
2594581
2594582
2594584
2594585
2594587
2594591
2594594
2594597
2594599
2594601
2594604
2594605
2594607
2594610
2594613
2594614
2594615
2594616
39943_at
4999
76120_at
8058161
A_23_P39616
A_33_P3381410
GE59042
GE858128
GO:0000122
GO:0000228
GO:0000781
GO:0000785
GO:0000792
GO:0000808
GO:0000939
GO:0003677
GO:0003688
GO:0005515
GO:0005634
GO:0005654
GO:0005664
GO:0005694
GO:0005813
GO:0005815
GO:0005856
GO:0006260
GO:0006270
GO:0006351
GO:0006355
GO:0016020
GO:0043226
HMNXSV003015894
HMNXSV003026356
Hs.115572.0.A1_3p_at
ILMN_2061452
PH_hs_0022794
TC02002669.hg
TC02004778.hg
U27459_at
g5453829_3p_at
Participates
as an input of
ORC2 binds ORC3 (Homo sapiens)
as a component of
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
Inferred To
orcB [nucleoplasm]
(Dictyostelium discoideum)
orc-2 [nucleoplasm]
(Caenorhabditis elegans)
Orc2 [nucleoplasm]
(Drosophila melanogaster)
Orc2 [nucleoplasm]
(Mus musculus)
Orc2 [nucleoplasm]
(Rattus norvegicus)
orc2 [nucleoplasm]
(Schizosaccharomyces pombe)
orc2 [nucleoplasm]
(Xenopus tropicalis)
ORC2 [nucleoplasm]
(Bos taurus)
ORC2 [nucleoplasm]
(Canis familiaris)
ORC2 [nucleoplasm]
(Danio rerio)
ORC2 [nucleoplasm]
(Gallus gallus)
ORC2 [nucleoplasm]
(Plasmodium falciparum)
ORC2 [nucleoplasm]
(Saccharomyces cerevisiae)
ORC2 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_006181.1
,
XP_006712618.1
OpenTargets
ENSG00000115942
HPA
ENSG00000115942-ORC2
GeneCards
Q13416
Ensembl
ENSG00000115942
,
ENSP00000234296
,
ENST00000234296
PRO
Q13416
Pharos - Targets
Q13416
PDB
7JPS
,
5UJ8
,
7CTF
,
7JPR
,
7JPP
,
7CTE
,
7JPQ
,
5C8H
,
7JPO
,
7CTG
,
5UJM
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13415 ORC1
5
ORC1 [nucleoplasm]
(R-HSA-68522)
ORC1 [cytosol]
(R-HSA-113840)
p-S,T-ORC1 [nucleoplasm]
(R-HSA-68943)
PolyUb,p-S,T-ORC1 [nucleoplasm]
(R-HSA-9032189)
PolyUb,p-S,T-ORC1 [cytosol]
(R-HSA-9032195)
0.888
14
UniProt:O43929 ORC4
1
ORC4 [nucleoplasm]
(R-HSA-68519)
0.813
12
UniProt:O43913 ORC5
1
ORC5 [nucleoplasm]
(R-HSA-68516)
0.81
15
UniProt:Q7L590 MCM10
1
MCM10 [nucleoplasm]
(R-HSA-68403)
0.715
5
UniProt:Q9UBD5 ORC3
1
ORC3 [nucleoplasm]
(R-HSA-68513)
0.702
28
UniProt:P03211 EBNA1
0.656
6
UniProt:Q15554 TERF2
2
TERF2 [nucleoplasm]
(R-HSA-174895)
p-S365-TERF2 [nucleoplasm]
(R-HSA-9686530)
0.602
3
UniProt:Q99459 CDC5L
1
CDC5L [nucleoplasm]
(R-HSA-5420887)
0.59
2
UniProt:P57055 DSCR6
0.556
3
UniProt:Q9UI47-2 CTNNA3
0.556
3
UniProt:Q9NS91 RAD18
1
RAD18 [nucleoplasm]
(R-HSA-5643731)
0.556
3
UniProt:Q9Y5N6 ORC6
4
ORC6 [nucleoplasm]
(R-HSA-68539)
ORC6 [cytosol]
(R-HSA-9734663)
p-T195-ORC6 [cytosol]
(R-HSA-9734682)
p-T195-ORC6 [nucleoplasm]
(R-HSA-9734715)
0.527
2
UniProt:P25205 MCM3
1
MCM3 [nucleoplasm]
(R-HSA-68546)
0.499
2
UniProt:Q08050 FOXM1
3
p-T611,S730,S739-FOXM1 [nucleoplasm]
(R-HSA-4088133)
p-T611-FOXM1 [nucleoplasm]
(R-HSA-4088026)
FOXM1 [nucleoplasm]
(R-HSA-4088019)
0.499
2
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