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Glutathione synthesis and recycling
Stable Identifier
R-HSA-174403
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase II - Conjugation of compounds (Homo sapiens)
Glutathione conjugation (Homo sapiens)
Glutathione synthesis and recycling (Homo sapiens)
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The combination of glutamate, cysteine and ATP is required to form glutathione. The steps involved in the synthesis and recycling of glutathione are outlined (Meister, 1988).
Literature References
PubMed ID
Title
Journal
Year
3053703
Glutathione metabolism and its selective modification
Meister, A
J Biol Chem
1988
Participants
Events
OPLAH hydrolyses OPRO to L-Glu
(Homo sapiens)
GCL ligates L-Glu to L-Cys
(Homo sapiens)
GGCT transforms gGluCys to OPRO
(Homo sapiens)
GSS:Mg2+ dimer synthesizes GSH
(Homo sapiens)
GSH translocates from cytosol to extracellular region
(Homo sapiens)
GGT dimers hydrolyse GSH
(Homo sapiens)
CysGly translocates from extracellular region to cytosol
(Homo sapiens)
CNDP2:2Mn2+ dimer hydrolyses CysGly
(Homo sapiens)
CHAC1,2 cleaves GSH to OPRO and CysGly
(Homo sapiens)
Participates
as an event of
Glutathione conjugation (Homo sapiens)
Event Information
Go Biological Process
glutathione biosynthetic process (0006750)
Orthologous Events
Glutathione synthesis and recycling (Bos taurus)
Glutathione synthesis and recycling (Caenorhabditis elegans)
Glutathione synthesis and recycling (Canis familiaris)
Glutathione synthesis and recycling (Danio rerio)
Glutathione synthesis and recycling (Dictyostelium discoideum)
Glutathione synthesis and recycling (Drosophila melanogaster)
Glutathione synthesis and recycling (Gallus gallus)
Glutathione synthesis and recycling (Mus musculus)
Glutathione synthesis and recycling (Plasmodium falciparum)
Glutathione synthesis and recycling (Rattus norvegicus)
Glutathione synthesis and recycling (Saccharomyces cerevisiae)
Glutathione synthesis and recycling (Schizosaccharomyces pombe)
Glutathione synthesis and recycling (Sus scrofa)
Glutathione synthesis and recycling (Xenopus tropicalis)
Authored
Jassal, B (2004-11-30)
Reviewed
D'Eustachio, P (2011-05-23)
Created
Jassal, B (2006-02-17)
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