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GSH translocates from cytosol to extracellular region
Stable Identifier
R-HSA-1247915
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase II - Conjugation of compounds (Homo sapiens)
Glutathione conjugation (Homo sapiens)
Glutathione synthesis and recycling (Homo sapiens)
GSH translocates from cytosol to extracellular region (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Glutathione is exported out of the cell to be made available for membrane-bound gamma-glutamyl transpeptidases (GGTs). Cells that have GGTs can utilize translocated glutathione. The exact transport mechanism is uncertain (Griffith and Meister, 1979; Griffith et al, 1979).
Literature References
PubMed ID
Title
Journal
Year
42913
Transport of gamma-glutamyl amino acids: role of glutathione and gamma-glutamyl transpeptidase
Griffith, OW
,
Bridges, RJ
,
Meister, A
Proc Natl Acad Sci U S A
1979
34150
Translocation of intracellular glutathione to membrane-bound gamma-glutamyl transpeptidase as a discrete step in the gamma-glutamyl cycle: glutathionuria after inhibition of transpeptidase
Griffith, OW
,
Meister, A
Proc Natl Acad Sci U S A
1979
Participants
Input
GSH [cytosol]
Output
GSH [extracellular region]
Participates
as an event of
Glutathione synthesis and recycling (Homo sapiens)
Event Information
Go Biological Process
glutathione transmembrane transport (0034775)
Cross References
RHEA
74819
Authored
Jassal, B (2011-04-08)
Reviewed
D'Eustachio, P (2011-05-23)
Created
Jassal, B (2011-04-08)
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