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CysGly translocates from extracellular region to cytosol
Stable Identifier
R-HSA-1247939
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase II - Conjugation of compounds (Homo sapiens)
Glutathione conjugation (Homo sapiens)
Glutathione synthesis and recycling (Homo sapiens)
CysGly translocates from extracellular region to cytosol (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The hydrolysis product of glutathione, cysteinylglycine (CysGly) is transported back into the cell to replenish the precursor resevoir for the resynthesis of glutathione. The exact mechanism of uptake is unknown (Griffith et al. 1978).
Literature References
PubMed ID
Title
Journal
Year
31622
Evidence that the gamma-glutamyl cycle functions in vivo using intracellular glutathione: effects of amino acids and selective inhibition of enzymes
Bridges, RJ
,
Meister, A
,
Griffith, OW
Proc Natl Acad Sci U S A
1978
Participants
Input
CysGly [extracellular region]
Output
CysGly [cytosol]
Participates
as an event of
Glutathione synthesis and recycling (Homo sapiens)
Authored
Jassal, B (2011-04-08)
Reviewed
D'Eustachio, P (2011-05-23)
Created
Jassal, B (2011-04-08)
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