Reactome | CHAC1,2 cleaves GSH to OPRO and CysGly

CHAC1,2 cleaves GSH to OPRO and CysGly

Stable Identifier

R-HSA-6785928

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Glutathione-specific gamma-glutamylcyclotransferases 1 and 2 (CHAC1 and 2) catalyse the specific cleavage of glutathione (GSH) into 5-oxoproline (OPRO) and a cysteinylglycine (CysGly) dipeptide. GSH acts a redox buffer in cells and its depletion is an important factor for apoptosis, oxidative stress and progression of cancer. CHAC1 and 2 act as proapototic agents with implications for human health and disease (Mungrue et al. 2009, Crawford et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
19109178	CHAC1/MGC4504 is a novel proapoptotic component of the unfolded protein response, downstream of the ATF4-ATF3-CHOP cascade Mungrue, IN, Gargalovic, PS, Kohannim, O, Lusis, AJ, Pagnon, J	J. Immunol.	2009
25931127	Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element Mungrue, IN, Kilberg, MS, Shan, J, Sylvester, CF, Higdon, AN, Crawford, RR, Prescott, ET	J. Biol. Chem.	2015