Reactome | CHAC1,2 cleaves GSH to OPRO and CysGly

CHAC1,2 cleaves GSH to OPRO and CysGly

Stable Identifier

R-HSA-6785928

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Glutathione-specific gamma-glutamylcyclotransferases 1 and 2 (CHAC1 and 2) catalyse the specific cleavage of glutathione (GSH) into 5-oxoproline (OPRO) and a cysteinylglycine (CysGly) dipeptide. GSH acts a redox buffer in cells and its depletion is an important factor for apoptosis, oxidative stress and progression of cancer. CHAC1 and 2 act as proapototic agents with implications for human health and disease (Mungrue et al. 2009, Crawford et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
19109178	CHAC1/MGC4504 is a novel proapoptotic component of the unfolded protein response, downstream of the ATF4-ATF3-CHOP cascade Mungrue, IN, Pagnon, J, Kohannim, O, Gargalovic, PS, Lusis, AJ	J. Immunol.	2009
25931127	Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element Crawford, RR, Prescott, ET, Sylvester, CF, Higdon, AN, Shan, J, Kilberg, MS, Mungrue, IN	J. Biol. Chem.	2015