Synthesis and processing of ENV and VPU

Stable Identifier
R-HSA-171286
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
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The two viral membrane proteins, Env and the accessory protein Vpu, which are encoded by the same mRNA, are translated on the rough ER. All virion components need to traffic from their point of synthesis to sites of assembly on the plasma membrane. Env is an integral membrane protein. It is inserted cotranslationally into ER membranes and then travels through the cellular secretory pathway where it is glycosylated, assembled into trimeric complexes, processed into the gp41 and gp120 subunits by the cellular protease furin.

Literature References
PubMed ID Title Journal Year
22762019 HIV-1 Assembly, Budding, and Maturation

Sundquist, WI, Kräusslich, HG

Cold Spring Harb Perspect Med 2012
Participants
Participant Of
Event Information
Go Biological Process
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
Authored
Reviewed
Created
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