Synthesis of VPU protein

Stable Identifier
R-HSA-3149433
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
cytoplasm
ReviewStatus
5/5
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Synthesis of VPU protein
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As the Rev protein accumulates, nuclear export of the singly and unspliced mRNAs is facilitated. These mRNAs express the Vif, Vpr, Vpu, Env proteins and the Gag and Gag-Pol polyproteins, respectively, and require Rev, which overcomes the restriction of nuclear export of intron-containing transcripts by accessing the CRM1 nuclear export pathway
Literature References
PubMed ID Title Journal Year
20082634 Alternative splicing: regulation of HIV-1 multiplication as a target for therapeutic action

Ayadi, L, Marchand, V, Bakkour, N, Branlant, C, Aboufirassi, A, Tazi, J

FEBS J. 2010
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Gillespie, ME  (2013-03-07)
Reviewed
Dube, M  (2013-05-21)
Created
Gillespie, ME  (2013-02-14)
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