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Transport of VPU to Plasma Membrane
Stable Identifier
R-HSA-3149432
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
viral envelope
ReviewStatus
5/5
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HIV Infection (Homo sapiens)
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Late Phase of HIV Life Cycle (Homo sapiens)
Assembly Of The HIV Virion (Homo sapiens)
Synthesis and processing of ENV and VPU (Homo sapiens)
Transport of VPU to Plasma Membrane (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Once transported to the plasma membrane the VPU protein will be incorporated into the assembling virus. The Vpu accessory protein is found to be required for efficient virion release from some cell lines but completely dispensible in others.
Literature References
PubMed ID
Title
Journal
Year
22553496
HIV Restriction Factors and Mechanisms of Evasion
Bieniasz, PD
,
Malim, MH
Cold Spring Harb Perspect Med
2012
Participants
Input
VPU (P05919) [Golgi membrane]
(Human immunodeficiency virus 1)
Output
VPU (P05919) [plasma membrane]
(Human immunodeficiency virus 1)
Participates
as an event of
Synthesis and processing of ENV and VPU (Homo sapiens)
Disease
Name
Identifier
Synonyms
Human immunodeficiency virus infectious disease
DOID:526
HIV infection
Authored
Gillespie, ME (2013-03-07)
Reviewed
Dube, M (2013-05-21)
Created
Gillespie, ME (2013-02-14)
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