Cleavage of the viral Env gp160 precursor polyprotein

Stable Identifier
R-HSA-171288
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
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The trimeric gp160 complexes are cleaved into the gp41 and gp120 subunits by the cellular protease furin.

Literature References
PubMed ID Title Journal Year
8163529 The convertases furin and PC1 can both cleave the human immunodeficiency virus (HIV)-1 envelope glycoprotein gp160 into gp120 (HIV-1 SU) and gp41 (HIV-I TM)

Decroly, E, Vandenbranden, M, Ruysschaert, JM, Cogniaux, J, Jacob, GS, Howard, SC, Marshall, G, Kompelli, A, Basak, A, Jean, F

J. Biol. Chem. 1994
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of FURIN [Golgi membrane]
Physical Entity
Activity
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
Authored
Reviewed
Created
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