Cleavage of the viral Env gp160 precursor polyprotein

Stable Identifier
R-HSA-171288
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
cytosol
ReviewStatus
5/5
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Cleavage of the viral Env gp160 precursor polyprotein
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The trimeric gp160 complexes are cleaved into the gp41 and gp120 subunits by the cellular protease furin.
Literature References
PubMed ID Title Journal Year
8163529 The convertases furin and PC1 can both cleave the human immunodeficiency virus (HIV)-1 envelope glycoprotein gp160 into gp120 (HIV-1 SU) and gp41 (HIV-I TM)

Kompelli, A, Jean, F, Ruysschaert, JM, Marshall, G, Cogniaux, J, Decroly, E, Basak, A, Howard, SC, Jacob, GS, Vandenbranden, M

J. Biol. Chem. 1994
Participants
Input
Output
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as an event of
Catalyst Activity

serine-type endopeptidase activity of FURIN [Golgi membrane]

Physical Entity
FURIN [Golgi membrane] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Gopinathrao, G  (2006-02-10)
Reviewed
Dube, M  (2013-05-21)
Created
Gopinathrao, G  (2006-02-03)
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