Transport of trimeric gp41:gp120 to plasma membrane

Stable Identifier
R-HSA-173647
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
cytoplasm
ReviewStatus
5/5
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Transport of trimeric gp41:gp120 to plasma membrane
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The cleaved and assembled gp41:gp121 complexes are transport to teh plasma membrane. This complex ultimately arrives via the cellular secretion pathway. Env is an integral membrane protein shuttled through the ER and Golgi where it was glycosylated and cleaved into the gp41 and gp120 subunits. The trimeric complex is brought to the plasma membrane by the host vesicular transport system. Only 7-14 trimers are present per virion.
Literature References
PubMed ID Title Journal Year
2002555 Human immunodeficiency virus type 1 gp120 envelope glycoprotein regions important for association with the gp41 transmembrane glycoprotein

Sodroski, J, Olshevsky, U, Helseth, E, Furman, C

J Virol 1991
Participants
Input
Output
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as an event of
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Gillespie, ME  (2013-03-07)
Reviewed
Dube, M  (2013-05-21)
Created
Gopinathrao, G  (2006-02-16)
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