Reactome | MAP2K3 [cytosol]

MAP2K3 [cytosol]

Stable Identifier

R-CFA-168051

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

MAP2K3, A0A5F4D9C2

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Cytokine Signaling in Immune system (Canis familiaris)
  - Signaling by Interleukins (Canis familiaris)
    - Interleukin-17 signaling (Canis familiaris)
      - MAP kinase activation (Canis familiaris)
        
        activated TAK1 mediates p38 MAPK activation (Canis familiaris)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
        
        MAP2K3,MAP2K6 [cytosol] (Canis familiaris)
        
        MAP2K3 [cytosol] (Canis familiaris)
- Innate Immune System (Canis familiaris)
  - Toll-like Receptor Cascades (Canis familiaris)
    - Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
      - MyD88 cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        activated TAK1 mediates p38 MAPK activation (Canis familiaris)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
        
        MAP2K3,MAP2K6 [cytosol] (Canis familiaris)
        
        MAP2K3 [cytosol] (Canis familiaris)
    - Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
      - Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        activated TAK1 mediates p38 MAPK activation (Canis familiaris)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
        
        MAP2K3,MAP2K6 [cytosol] (Canis familiaris)
        
        MAP2K3 [cytosol] (Canis familiaris)
      - Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        activated TAK1 mediates p38 MAPK activation (Canis familiaris)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
        
        MAP2K3,MAP2K6 [cytosol] (Canis familiaris)
        
        MAP2K3 [cytosol] (Canis familiaris)
    - Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
      - MAP kinase activation (Canis familiaris)
        
        activated TAK1 mediates p38 MAPK activation (Canis familiaris)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
        
        MAP2K3,MAP2K6 [cytosol] (Canis familiaris)
        
        MAP2K3 [cytosol] (Canis familiaris)
    - Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
      - MyD88-independent TLR4 cascade (Canis familiaris)
        
        TRIF(TICAM1)-mediated TLR4 signaling (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        activated TAK1 mediates p38 MAPK activation (Canis familiaris)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
        
        MAP2K3,MAP2K6 [cytosol] (Canis familiaris)
        
        MAP2K3 [cytosol] (Canis familiaris)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        activated TAK1 mediates p38 MAPK activation (Canis familiaris)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
        
        MAP2K3,MAP2K6 [cytosol] (Canis familiaris)
        
        MAP2K3 [cytosol] (Canis familiaris)
    - Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
      - MyD88 cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        activated TAK1 mediates p38 MAPK activation (Canis familiaris)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
        
        MAP2K3,MAP2K6 [cytosol] (Canis familiaris)
        
        MAP2K3 [cytosol] (Canis familiaris)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
      - MyD88 dependent cascade initiated on endosome (Canis familiaris)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        activated TAK1 mediates p38 MAPK activation (Canis familiaris)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
        
        MAP2K3,MAP2K6 [cytosol] (Canis familiaris)
        
        MAP2K3 [cytosol] (Canis familiaris)
    - Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
      - MyD88 dependent cascade initiated on endosome (Canis familiaris)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        activated TAK1 mediates p38 MAPK activation (Canis familiaris)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
        
        MAP2K3,MAP2K6 [cytosol] (Canis familiaris)
        
        MAP2K3 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A5F4D9C2

Gene Names

MAP2K3

Reference Genes

ENSEMBL:ENSCAFG00000018530

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000018530 MAP2K3

Other Identifiers

489547

Cfa.18291.1.S1_s_at

Cfa.21593.1.S1_s_at

CfaAffx.28330.1.S1_at

GO:0000165

GO:0000187

GO:0001817

GO:0003013

GO:0003674

GO:0004672

GO:0004708

GO:0005524

GO:0006464

GO:0006468

GO:0006950

GO:0006954

GO:0007165

GO:0008150

GO:0009058

GO:0016301

GO:0019899

GO:0019901

GO:0034641

GO:0035331

GO:0035924

GO:0038066

GO:0040011

GO:0043167

GO:0043536

GO:0045860

GO:0045893

GO:0048870

GO:0060048

Participates

as a member of

MAP2K3,MAP2K6 [cytosol] (Canis familiaris)

Other forms of this molecule

phospho-MAP2K3 [cytosol]

phospho-MAP2K3 [nucleoplasm]

Inferred From

MAP2K3 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000034152

Ensembl

ENSCAFG00000018530, ENSCAFT00000072751, ENSCAFP00000061410

VGNC

42961

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