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C4A(20-675) [extracellular region]
Stable Identifier
R-HSA-166734
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
C4A beta, Complement factor 4A beta chain
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Activation of C3 and C5 (Homo sapiens)
Activation of C5 (Homo sapiens)
C5 convertases [plasma membrane] (Homo sapiens)
C4b:C2a:C3b [plasma membrane] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
Cleavage of C3 by C3 convertases (Homo sapiens)
C3 convertases [plasma membrane] (Homo sapiens)
C4b:C2a:C3b [plasma membrane] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
Formation of classic pathway C5 convertase (Homo sapiens)
C4b:C2a:C3b [plasma membrane] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
Initial triggering of complement (Homo sapiens)
C4b binds to cell surface (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
C4A(20-675):C4A(1454-1744):S-(L-isoglutamyl)-L-cysteine-C4A(757-1446) [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
Conversion of C4 into C4a and C4b (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
C4A(20-675):C4A(1454-1744):S-(L-isoglutamyl)-L-cysteine-C4A(757-1446) [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
Complement Factor 4 [extracellular region] (Homo sapiens)
Complement factor 4A [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
Formation of Classical C3 convertase (C4b:C2a complex) (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
Regulation of Complement cascade (Homo sapiens)
C3 convertases spontaneously dissociate (Homo sapiens)
C3 convertases [plasma membrane] (Homo sapiens)
C4b:C2a:C3b [plasma membrane] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
C4b binding protein binds C4bC2a (Homo sapiens)
C4 binding protein:C4bC2a [plasma membrane] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
C4b binding protein displaces C2a (Homo sapiens)
C4 binding protein:C4bC2a [plasma membrane] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
C4-binding protein:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
C4A(20-675):C4A(1454-1744):S-(L-isoglutamyl)-L-cysteine-C4A(757-1446) [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
C4b-binding protein binds C4b (Homo sapiens)
C4-binding protein:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
C4A(20-675):C4A(1454-1744):S-(L-isoglutamyl)-L-cysteine-C4A(757-1446) [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
C4A(20-675):C4A(1454-1744):S-(L-isoglutamyl)-L-cysteine-C4A(757-1446) [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
CD46 binds C4b (Homo sapiens)
CD46:Cell surface:C4b [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
CD55 (DAF) binds C3bBb, C4bC2a (Homo sapiens)
C4bC2a, C3bBb [plasma membrane] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
CD55:C3 convertase complexes [plasma membrane] (Homo sapiens)
CD55:C4bC2a [plasma membrane] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Homo sapiens)
CD55:C3 convertase complexes [plasma membrane] (Homo sapiens)
CD55:C4bC2a [plasma membrane] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
CD55:C4b [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
CR1 binds C3bBb/C4bC2a (Homo sapiens)
C4bC2a, C3bBb [plasma membrane] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
CR1:C3bBb, C4bC2a complexes [plasma membrane] (Homo sapiens)
CR1:C4bC2a [plasma membrane] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
Complement factor I binds C4BP (Homo sapiens)
C4-binding protein:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
C4A(20-675):C4A(1454-1744):S-(L-isoglutamyl)-L-cysteine-C4A(757-1446) [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
C4b-binding protein:Factor I [plasma membrane] (Homo sapiens)
C4-binding protein:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
C4A(20-675):C4A(1454-1744):S-(L-isoglutamyl)-L-cysteine-C4A(757-1446) [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
Complement factor I binds to MCP, CR1:C4b, C3b (Homo sapiens)
CD46, CR1:C4b:C3b complexes [plasma membrane] (Homo sapiens)
CD46:Cell surface:C4b [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
CR1:C4b [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
CFI:CD46, CR1:C4b, C3b complexes [plasma membrane] (Homo sapiens)
CD46, CR1:C4b:C3b complexes [plasma membrane] (Homo sapiens)
CD46:Cell surface:C4b [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
CR1:C4b [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
Complement factor I inactivates C4BP-bound C4b (Homo sapiens)
C4b-binding protein:Factor I [plasma membrane] (Homo sapiens)
C4-binding protein:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
C4A(20-675):C4A(1454-1744):S-(L-isoglutamyl)-L-cysteine-C4A(757-1446) [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
C4c [extracellular region] (Homo sapiens)
C4A-derived C4c [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
Displacement of C2a/Bb by CR1 (Homo sapiens)
CR1:C3bBb, C4bC2a complexes [plasma membrane] (Homo sapiens)
CR1:C4bC2a [plasma membrane] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
CR1:C4b [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
Factor I inactivates MCP/CR1-bound C4b/C3b (Homo sapiens)
C4c, C3f [extracellular region] (Homo sapiens)
C4c [extracellular region] (Homo sapiens)
C4A-derived C4c [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
CFI:CD46, CR1:C4b, C3b complexes [plasma membrane] (Homo sapiens)
CD46, CR1:C4b:C3b complexes [plasma membrane] (Homo sapiens)
CD46:Cell surface:C4b [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
CR1:C4b [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
Hydrolysis of internal thioester in C4b (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
C4A(20-675):C4A(1454-1744):S-(L-isoglutamyl)-L-cysteine-C4A(757-1446) [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
C4b with hydrolysed thioester [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4A(20-675) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P0C0L4 C4A
Gene Names
C4A, CO4, CPAMD2
Chain
signal peptide:1-19, chain:20-675, propeptide:676-679, chain:680-1446, chain:680-756, chain:757-1446, chain:957-1336, propeptide:1447-1453, chain:1454-1744
Reference Genes
BioGPS Gene:720 C4A
BioGPS Gene:721 C4A
COSMIC (genes):C4A C4A
CTD Gene:720 C4A
CTD Gene:721 C4A
dbSNP Gene:720 C4A
dbSNP Gene:721 C4A
ENSEMBL:ENSG00000244731 C4A
ENSEMBL_homo_sapiens_GENE:ENSG00000206340.10 C4A
ENSEMBL_homo_sapiens_GENE:ENSG00000227746.10 C4A
ENSEMBL_homo_sapiens_GENE:ENSG00000244731.10 C4A
HGNC:1323 C4A
KEGG Gene (Homo sapiens):720 C4A
KEGG Gene (Homo sapiens):721 C4A
Monarch:720 C4A
Monarch:721 C4A
NCBI Gene:720 C4A
NCBI Gene:721 C4A
OMIM:120810 C4A
UCSC:P0C0L4 C4A
Reference Transcript
RefSeq:NM_001252204.1 C4A
RefSeq:NM_001002029.3 C4A
RefSeq:NM_007293.2 C4A
Other Identifiers
110384692
11734747_a_at
11749926_a_at
11754270_a_at
17007048
17007118
17028176
17030967
17031045
17035749
17038462
17041030
17041111
208451_PM_s_at
208451_s_at
214428_PM_x_at
214428_x_at
2902959
2902960
2902961
2902962
2902963
2902964
2902965
2902966
2902967
2902969
2902970
2902972
2902973
2902974
2902975
2902976
2902977
2902978
2902979
2902980
2902981
2902982
2902983
2902984
2902985
2902986
2902988
2902989
2902991
2902993
2902994
2902995
2902997
2902998
2902999
2903000
2903001
2903002
2903003
2903004
2903005
2903006
2903007
2903009
2903010
2903012
2903015
2903017
2903018
2903020
2903022
2903024
2903026
2903027
2903028
40766_at
720
74611_s_at
8118409
8118455
8179399
A_14_P137370
A_23_P42282
GE62331
GO:0001849
GO:0002376
GO:0004866
GO:0005515
GO:0005576
GO:0005615
GO:0005783
GO:0005788
GO:0005886
GO:0006954
GO:0006956
GO:0006958
GO:0016192
GO:0030424
GO:0030425
GO:0042995
GO:0043025
GO:0043226
GO:0045087
GO:0045202
GO:0070062
GO:0072562
GO:0098542
GO:0098772
GO:2000427
HMNXSV003024675
ILMN_1813695
ILMN_2179533
M59815_at
PH_hs_0031857
TC06002720.hg
TC06004079.hg
TC06004080.hg
TC6_cox_hap2000227.hg
TC6_dbb_hap3000078.hg
TC6_dbb_hap3000224.hg
TC6_mcf_hap5000068.hg
TC6_mcf_hap5000197.hg
TC6_qbl_hap6000208.hg
TC6_ssto_hap7000071.hg
TC6_ssto_hap7000201.hg
g5579450_3p_s_at
Participates
as a component of
C4A-derived C4c [extracellular region] (Homo sapiens)
Complement factor 4A [extracellular region] (Homo sapiens)
C4A(20-675):C4A(1454-1744):S-(L-isoglutamyl)-L-cysteine-C4A(757-1446) [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
Other forms of this molecule
p-C4A [endoplasmic reticulum lumen]
C4A [endoplasmic reticulum lumen]
C4A alpha4 fragment [extracellular region]
C4A alpha3 [extracellular region]
C4A(956-1336) [plasma membrane]
C4A-derived C4a [extracellular region]
C4 alpha [extracellular region]
S-(L-isoglutamyl)-L-cysteine-C4A(757-1446) [extracellular region]
C4A(1454-1744) [extracellular region]
dNQ-C4A(757-1446) [extracellular region]
Inferred To
Homologues of C4A(20-675) [extracellular region]
(Bos taurus)
Homologues of C4A(20-675) [extracellular region]
(Rattus norvegicus)
c4a [extracellular region]
(Xenopus tropicalis)
C4A [extracellular region]
(Bos taurus)
C4A [extracellular region]
(Sus scrofa)
C4b [extracellular region]
(Mus musculus)
C4b [extracellular region]
(Rattus norvegicus)
LOC481722 [extracellular region]
(Canis familiaris)
C4A(20-675) [extracellular region]
(Gallus gallus)
C4 [extracellular region]
(Rattus norvegicus)
LOC107131209 [extracellular region]
(Bos taurus)
Cross References
RefSeq
NP_009224.2
,
NP_001002029.3
,
NP_001239133.1
OpenTargets
ENSG00000244731
HPA
ENSG00000244731-C4A
GeneCards
P0C0L4
Ensembl
ENSG00000206340
,
ENSP00000396688
,
ENSG00000244731
,
ENSG00000227746
,
ENST00000383325
,
ENST00000421274
,
ENST00000498271
,
ENST00000428956
,
ENSP00000420212
,
ENSP00000388662
,
ENSP00000372815
PRO
P0C0L4
Pharos - Targets
P0C0L4
Orphanet
17447
PDB
5JTW
,
1HZF
,
6YSQ
,
5JPM
,
5JPN
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16625 OCLN
4
OCLN [cell junction]
(R-HSA-2160944)
OCLN(1-320) [plasma membrane]
(R-HSA-351854)
OCLN(321-522) [plasma membrane]
(R-HSA-351873)
OCLN [plasma membrane]
(R-HSA-351846)
0.527
2
UniProt:P13501 CCL5
1
CCL5(24-91) [extracellular region]
(R-HSA-373108)
0.527
2
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![C4A(20-675) [extracellular region] icon](/icon/R-ICO-014075.svg){kind=icon}
