Reactome | C4b [extracellular region]

C4b [extracellular region]

Stable Identifier

R-MMU-166734

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

extracellular region

Synonyms

C4A(20-675), P01029

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Innate Immune System (Mus musculus)
  - Complement cascade (Mus musculus)
    - Activation of C3 and C5 (Mus musculus)
      - Activation of C5 (Mus musculus)
        
        C5 convertases [plasma membrane] (Mus musculus)
        
        C4b:C2a:C3b [plasma membrane] (Mus musculus)
        
        Cell surface:C4b:C2a [plasma membrane] (Mus musculus)
        
        Cell surface:C4b [plasma membrane] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated, estrer-crosslinked-Q1013-C4B-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
      - Cleavage of C3 by C3 convertases (Mus musculus)
        
        C3 convertases [plasma membrane] (Mus musculus)
        
        C4b:C2a:C3b [plasma membrane] (Mus musculus)
        
        Cell surface:C4b:C2a [plasma membrane] (Mus musculus)
        
        Cell surface:C4b [plasma membrane] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated, estrer-crosslinked-Q1013-C4B-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        Cell surface:C4b:C2a [plasma membrane] (Mus musculus)
        
        Cell surface:C4b [plasma membrane] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated, estrer-crosslinked-Q1013-C4B-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
      - Formation of classic pathway C5 convertase (Mus musculus)
        
        C4b:C2a:C3b [plasma membrane] (Mus musculus)
        
        Cell surface:C4b:C2a [plasma membrane] (Mus musculus)
        
        Cell surface:C4b [plasma membrane] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated, estrer-crosslinked-Q1013-C4B-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        Cell surface:C4b:C2a [plasma membrane] (Mus musculus)
        
        Cell surface:C4b [plasma membrane] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated, estrer-crosslinked-Q1013-C4B-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
    - Initial triggering of complement (Mus musculus)
      - C4b binds to cell surface (Mus musculus)
        
        C4A(20-675):C4A(1454-1744):S-(L-isoglutamyl)-L-cysteine-C4A(757-1446) [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        Cell surface:C4b [plasma membrane] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated, estrer-crosslinked-Q1013-C4B-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
      - Conversion of C4 into C4a and C4b (Mus musculus)
        
        C4A(20-675):C4A(1454-1744):S-(L-isoglutamyl)-L-cysteine-C4A(757-1446) [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        Complement factor 4A [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
      - Formation of Classical C3 convertase (C4b:C2a complex) (Mus musculus)
        
        Cell surface:C4b [plasma membrane] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated, estrer-crosslinked-Q1013-C4B-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        Cell surface:C4b:C2a [plasma membrane] (Mus musculus)
        
        Cell surface:C4b [plasma membrane] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated, estrer-crosslinked-Q1013-C4B-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
    - Regulation of Complement cascade (Mus musculus)
      - C3 convertases spontaneously dissociate (Mus musculus)
        
        C3 convertases [plasma membrane] (Mus musculus)
        
        C4b:C2a:C3b [plasma membrane] (Mus musculus)
        
        Cell surface:C4b:C2a [plasma membrane] (Mus musculus)
        
        Cell surface:C4b [plasma membrane] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated, estrer-crosslinked-Q1013-C4B-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        Cell surface:C4b:C2a [plasma membrane] (Mus musculus)
        
        Cell surface:C4b [plasma membrane] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated, estrer-crosslinked-Q1013-C4B-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        Cell surface:C4b [plasma membrane] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated, estrer-crosslinked-Q1013-C4B-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        Cell surface:C4b:C2a [plasma membrane] (Mus musculus)
        
        Cell surface:C4b [plasma membrane] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated, estrer-crosslinked-Q1013-C4B-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
      - CD46 binds C4b (Mus musculus)
        
        CD46:Cell surface:C4b [plasma membrane] (Mus musculus)
        
        Cell surface:C4b [plasma membrane] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated, estrer-crosslinked-Q1013-C4B-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        Cell surface:C4b [plasma membrane] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated, estrer-crosslinked-Q1013-C4B-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
      - CD55 (DAF) binds C3bBb, C4bC2a (Mus musculus)
        
        C4bC2a, C3bBb [plasma membrane] (Mus musculus)
        
        Cell surface:C4b:C2a [plasma membrane] (Mus musculus)
        
        Cell surface:C4b [plasma membrane] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated, estrer-crosslinked-Q1013-C4B-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        CD55:C3 convertase complexes [plasma membrane] (Mus musculus)
        
        CD55:C4bC2a [plasma membrane] (Mus musculus)
        
        Cell surface:C4b:C2a [plasma membrane] (Mus musculus)
        
        Cell surface:C4b [plasma membrane] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated, estrer-crosslinked-Q1013-C4B-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
      - CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Mus musculus)
        
        CD55:C3 convertase complexes [plasma membrane] (Mus musculus)
        
        CD55:C4bC2a [plasma membrane] (Mus musculus)
        
        Cell surface:C4b:C2a [plasma membrane] (Mus musculus)
        
        Cell surface:C4b [plasma membrane] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated, estrer-crosslinked-Q1013-C4B-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        CD55:C4b [plasma membrane] (Mus musculus)
        
        Cell surface:C4b [plasma membrane] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated, estrer-crosslinked-Q1013-C4B-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
      - CR1 binds C3bBb/C4bC2a (Mus musculus)
        
        C4bC2a, C3bBb [plasma membrane] (Mus musculus)
        
        Cell surface:C4b:C2a [plasma membrane] (Mus musculus)
        
        Cell surface:C4b [plasma membrane] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated, estrer-crosslinked-Q1013-C4B-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        CR1:C3bBb, C4bC2a complexes [plasma membrane] (Mus musculus)
        
        CR1:C4bC2a [plasma membrane] (Mus musculus)
        
        Cell surface:C4b:C2a [plasma membrane] (Mus musculus)
        
        Cell surface:C4b [plasma membrane] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated, estrer-crosslinked-Q1013-C4B-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
      - Complement factor I binds to MCP, CR1:C4b, C3b (Mus musculus)
        
        CD46, CR1:C4b:C3b complexes [plasma membrane] (Mus musculus)
        
        CD46:Cell surface:C4b [plasma membrane] (Mus musculus)
        
        Cell surface:C4b [plasma membrane] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated, estrer-crosslinked-Q1013-C4B-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        CR1:C4b [plasma membrane] (Mus musculus)
        
        Cell surface:C4b [plasma membrane] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated, estrer-crosslinked-Q1013-C4B-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        CFI:CD46, CR1:C4b, C3b complexes [plasma membrane] (Mus musculus)
        
        CD46, CR1:C4b:C3b complexes [plasma membrane] (Mus musculus)
        
        CD46:Cell surface:C4b [plasma membrane] (Mus musculus)
        
        Cell surface:C4b [plasma membrane] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated, estrer-crosslinked-Q1013-C4B-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        CR1:C4b [plasma membrane] (Mus musculus)
        
        Cell surface:C4b [plasma membrane] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated, estrer-crosslinked-Q1013-C4B-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
      - Displacement of C2a/Bb by CR1 (Mus musculus)
        
        CR1:C3bBb, C4bC2a complexes [plasma membrane] (Mus musculus)
        
        CR1:C4bC2a [plasma membrane] (Mus musculus)
        
        Cell surface:C4b:C2a [plasma membrane] (Mus musculus)
        
        Cell surface:C4b [plasma membrane] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated, estrer-crosslinked-Q1013-C4B-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        CR1:C4b [plasma membrane] (Mus musculus)
        
        Cell surface:C4b [plasma membrane] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated, estrer-crosslinked-Q1013-C4B-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
      - Factor I inactivates MCP/CR1-bound C4b/C3b (Mus musculus)
        
        C4c, C3f [extracellular region] (Mus musculus)
        
        C4A-derived C4c [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        CFI:CD46, CR1:C4b, C3b complexes [plasma membrane] (Mus musculus)
        
        CD46, CR1:C4b:C3b complexes [plasma membrane] (Mus musculus)
        
        CD46:Cell surface:C4b [plasma membrane] (Mus musculus)
        
        Cell surface:C4b [plasma membrane] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated, estrer-crosslinked-Q1013-C4B-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        CR1:C4b [plasma membrane] (Mus musculus)
        
        Cell surface:C4b [plasma membrane] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated, estrer-crosslinked-Q1013-C4B-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
      - Hydrolysis of internal thioester in C4b (Mus musculus)
        
        C4A(20-675):C4A(1454-1744):S-(L-isoglutamyl)-L-cysteine-C4A(757-1446) [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Mus musculus)
        
        C4b [extracellular region] (Mus musculus)

External Reference Information

External Reference

UniProt:P01029

Gene Names

C4b

Reference Genes

BioGPS Gene:12268 C4b

ENSEMBL:ENSMUSG00000073418

ENSEMBL:ENSMUSG00000073418 C4b

KEGG Gene (Mus musculus):12268 C4b

Monarch:12268 C4b

NCBI Gene:12268 C4b

UCSC:P01029 C4b

Reference Transcript

RefSeq:NM_009780.2 C4b

Other Identifiers

103033_at

10450242

12268

1418021_at

17343918

4322221

4384982

4387425

4396319

4397737

4429434

4433854

4450799

4496642

4514219

4551938

4567654

4576891

4588182

4598424

4607296

4635822

4636456

4646286

4677931

4717303

4724681

4727303

4763482

4788700

4795236

4833963

4849086

4868663

4893323

4896424

4898943

4923699

4935041

4939893

4975008

4983764

4991915

5025929

5067736

5125066

5130035

5140240

5154076

5158970

5164270

5172911

5213105

5218160

5226000

5241320

5244754

5268282

5281787

5303794

5332349

5345801

5350448

5373468

5397791

5404615

5410882

5414893

5446496

5474710

5482561

5484476

5514914

5532479

5539369

5579267

A_55_P2078633

GE35134

GO:0001848

GO:0001849

GO:0002376

GO:0004866

GO:0005515

GO:0005576

GO:0005601

GO:0005615

GO:0006954

GO:0006956

GO:0006958

GO:0010951

GO:0016064

GO:0030246

GO:0030424

GO:0030425

GO:0032991

GO:0042995

GO:0043025

GO:0045087

GO:0045202

GO:0098542

GO:0098772

GO:0106139

ILMN_1215092

ILMN_1242744

ILMN_1246898

ILMN_2606624

ILMN_2632125

ILMN_2632563

ILMN_2632567

ILMN_2646052

ILMN_3049559

m17440_s_at

mMC019488

mMC022627

mMC022763

mMC023291

mMR030138

Participates

as a component of

Other forms of this molecule

phospho-C4b [endoplasmic reticulum lumen]

C4b [endoplasmic reticulum lumen]

C4b [extracellular region]

C4b [plasma membrane]

C4b [extracellular region]

Inferred From

C4B(20-675) [extracellular region] (Homo sapiens)

C4A(20-675) [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_033910.2

Ensembl

ENSMUSP00000069418, ENSMUSG00000073418, ENSMUST00000069507

PRO

P01029

MGI

88228

Cite Us!